Results 121 to 130 of about 2,096,911 (224)

Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy

open access: yesAdvanced Materials, EarlyView.
This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle   +9 more
wiley   +1 more source

Measles Virus: A Summary of Experiments Concerned with Isolation, Properties, and Behavior

open access: green, 1957
John F. Enders   +5 more
openalex   +2 more sources

Thermal inactivation spectrum of influenza A H5N1 virus in raw milk. [PDF]

open access: yesNat Commun
Nooruzzaman M   +7 more
europepmc   +1 more source

Porous Silicon Nanoneedles Efficiently Deliver Adenine Base Editor to Correct a Recurrent Pathogenic COL7A1 Variant in Recessive Dystrophic Epidermolysis Bullosa

open access: yesAdvanced Materials, EarlyView.
Base editing using nanoneedles efficiently corrects pathogenic variants in the type VII collagen gene of primary fibroblasts from patients with recessive dystrophic epidermolysis bullosa. Nanoneedle editing induces minimal and reversible transcriptional perturbations while restoring the production and secretion of functional type VII collagen.
Salman Ahmad Mustfa   +10 more
wiley   +1 more source

Seraph 100 Microbind Affinity Blood Filter for Persistent Pediatric BK Virus Nephropathy. [PDF]

open access: yesPediatr Transplant
Harris M   +4 more
europepmc   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

open access: yesAdvanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu   +4 more
wiley   +1 more source

Development of a reverse genetics system for Getah virus and characterization of rescued strains. [PDF]

open access: yesVet Res
Cai R   +11 more
europepmc   +1 more source

Off‐The‐Shelf Multivalent Nanoconjugate Cancer Vaccine Rescues Host Immune Response against Melanoma

open access: yesAdvanced Materials, EarlyView.
A star‐shaped cross‐linked polyglutamate (StCl) nanocarrier delivers melanoma‐associated peptide antigens via redox‐responsive linkers, inducing lymph node‐targeted antigen presentation. The nanoconjugate activates dendritic cells, promotes effector T‐cell responses, and enables tumor regression even in humanized patient‐derived preclinical models ...
Liane IF Moura   +19 more
wiley   +1 more source

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