Results 121 to 130 of about 2,627,962 (316)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Whole-Genome Sequencing and Structure Study of Three Biting-Insect–Associated Viruses (Yunnan Orbivirus, Guangxi Orbivirus, and Yongshan Totivirus) Isolated in Yunnan, China

Advances in Virology
Yunnan Province is an area in China with a major prevalence of biting arthropods (including mosquitos, ticks, and Culicoides) and arboviruses including dengue virus (DENV), bluetongue virus (BTV), and epizootic hemorrhagic disease virus (EHDV). Therefore,
Zhanhong Li, Yingliang Duan, Jianbo Zhu, Le Li   +3 more
doaj   +1 more source

Programmed death‐ligand 1 expression in Epstein‐Barr virus positive nasopharyngeal cancer

, 2022
Abdulhameed Alfagih, M A Rahman, Sadeq Al‐Dandan, Salem Alrehaili, Tariq Ahmad Wani, Abdulrahim Al Malki, Ali Al Zahrani, Hatoon Bakhribah   +7 more
openalex   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Melatonin protects mice infected with Venezuelan equine encephalomyelitis virus

, 1997
E. Bonilla, N Valero-Fuenmayor, Héctor Pons, L. Chac�n-Bonilla   +3 more
openalex   +2 more sources

Type 1 Interferon Responses Underlie Tumor-Selective Replication of Oncolytic Measles Virus

, 2020
Sarah Aref, Anna Castleton, Katharine Bailey, Richard Burt, Aditi Dey, Daniel Leongamornlert, Rachel J. Mitchell, Dina Okasha, Adele K. Fielding   +8 more
openalex   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Co-infection of malaria and influenza viruses in Uganda: A pilot study

International Journal of Infectious Diseases, 2014
B. Namagambo, J.T. Kayiwa, T. Byaruhanga, N. Owor, I. Nabukenya, B. Bakamutumaho, J.J. Lutwama   +6 more
doaj   +1 more source

Ebola virus [PDF]

BMJ, 1995
D, Bennett, D, Brown
openaire   +2 more sources

The MMP‐9/TIMP‐1 Ratio and Concentrations of Osteopontin Are Elevated in Cerebrospinal Fluid of People With Multiple Sclerosis and Decrease After Autologous Hematopoietic Stem Cell Transplantation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the utility of cerebrospinal fluid (CSF) biomarkers—matrix metalloproteinase‐9 (MMP‐9), tissue inhibitor of metalloproteinases‐1 (TIMP‐1), the MMP‐9/TIMP‐1 ratio, and osteopontin (OPN)—as indicators of blood–brain barrier (BBB) integrity and disease activity in people with relapsing–remitting multiple sclerosis (pwMS ...
Ivan Pavlovic, Ida Erngren, Kim Kultima, Anders Larsson, Malin Müller, Anna Wiberg, Joachim Burman   +6 more
wiley   +1 more source