Results 141 to 150 of about 6,298,490 (383)

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

Accelerating the Tempo of the Segmentation Clock by Reducing the Number of Introns in the Hes7 Gene

open access: yesCell Reports, 2013
Periodic somite segmentation is controlled by the cyclic gene Hes7, whose oscillatory expression depends upon negative feedback with a delayed timing.
Yukiko Harima   +4 more
doaj   +1 more source

Grippes aviaires en Afrique. Cibler la vigilance [PDF]

open access: yes, 2011
En 2006, la détection du virus de l'influenza (grippe) aviaire H5N1 en Afrique suscite une grande inquiétude : le virus pourrait se propager à l'ensemble du continent, puis être réintroduit en Europe par les oiseaux migrateurs.
Chevalier, Véronique   +2 more
core   +2 more sources

Virus hunting

open access: yesVirology, 2015
Viral diagnosis and discovery are receiving increasing emphasis with the recognition of their importance in addressing the challenges of emerging infectious and chronic diseases, and the advent of antiviral drugs with which to reduce the morbidity and mortality of viral infections.
Lipkin, W. Ian, Anthony, Simon J.
openaire   +2 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

Navigating Virology’s Frontiers in Africa: Global Virus Network 2024 Durban Meeting

open access: yesViruses
The Global Virus Network (GVN) is a voluntary consortium of virology laboratories and affiliated scientists that seek to prevent and control global viral threats.
Maggie L. Bartlett   +3 more
doaj   +1 more source

Roles of the membrane-reentrant β-hairpin-like loop of RseP protease in selective substrate cleavage

open access: yeseLife, 2015
Molecular mechanisms underlying substrate recognition and cleavage by Escherichia coli RseP, which belongs to S2P family of intramembrane-cleaving proteases, remain unclear.
Koichiro Akiyama   +5 more
doaj   +1 more source

Influenza Virus [PDF]

open access: yesTrends in Microbiology, 2018
This infographic briefly summarises the natural history, replication cycle, and pathogenesis of influenza viruses, the cause of seasonal influenza and of influenza pandemics. Influenza viruses infect many vertebrates, with Influenza A, B and C viruses (IAV, IBV, and ICV) infecting humans. High mutation rates allow the evasion of immunity.
openaire   +3 more sources

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

open access: yesMolecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo   +11 more
wiley   +1 more source

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