Results 151 to 160 of about 5,701,493 (405)

CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti‐tumoral compounds

Molecular Oncology, EarlyView.
FOXL2 c.402C>G mutation drives granulosa cell tumors. Using CRISPR technology, we selectively corrected this mutation, reducing malignancy and increasing sensitivity to dasatinib and ketoconazole. Transcriptomic changes revealed potential therapeutic targets, demonstrating CRISPR's promise for treating this rare ovarian cancer.
Sandra Amarilla‐Quintana, Paloma Navarro, Iván Hernández, Alejandra Ramos, Ana Montero‐Calle, Pablo Cabezas‐Sainz, Maria J Barrero, Diego Megías, Borja Vilaplana‐Martí, Carolina Epifano, Déborah Gómez‐Dominguez, Sara Monzón, Isabel Cuesta, Laura Sánchez, Rodrigo Barderas, Jesús García‐Donas, Alberto Martín, Ignacio Pérez de Castro   +17 more
wiley   +1 more source

Epidemics in Multipartite Networks: Emergent Dynamics [PDF]

arXiv, 2013
Single virus epidemics over complete networks are widely explored in the literature as the fraction of infected nodes is, under appropriate microscopic modeling of the virus infection, a Markov process. With non-complete networks, this macroscopic variable is no longer Markov.
arxiv  

Multiplex PCR method for MinION and Illumina sequencing of Zika and other virus genomes directly from clinical samples

Nature Protocols, 2017
Genome sequencing has become a powerful tool for studying emerging infectious diseases; however, genome sequencing directly from clinical samples (i.e., without isolation and culture) remains challenging for viruses such as Zika, for which metagenomic ...
J. Quick, N. Grubaugh, S. Pullan, I. Claro, Andrew D. Smith, K. Gangavarapu, G. Oliveira, R. Robles-Sikisaka, T. Rogers, N. Beutler, D. Burton, L. Lewis-Ximenez, J. D. de Jesus, M. Giovanetti, S. Hill, Allison Black, T. Bedford, M. Carroll, M. Nunes, L. Alcântara, E. Sabino, S. Baylis, N. Faria, M. Loose, J. Simpson, O. Pybus, K. Andersen, N. Loman   +27 more
semanticscholar   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

A Touch of Sleep: Biophysical Model of Contact-mediated Dormancy of Archaea by Viruses [PDF]

arXiv, 2015
The canonical view of the interactions between viruses and their microbial hosts presumes that changes in host and virus fate require the initiation of infection of a host by a virus. That is, first virus particles diffuse randomly outside of host cells, then the virus genome enters the target host cell, and only then do intracellular dynamics and ...
arxiv  

Viruses infecting carnations and dianthus species in New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Master of Horticultural Science at Massey University [PDF]

, 1975
Five viruses were detected in commercial carnations and these and a further four occurred in Dianthus species from gardens. Carnation mottle virus (CarMV) and carnation etched ring virus (CERV-50) were widespread in commercial carnations; arabis mosaic ...
Bennett, Peter Roger
core  

Evaluation of the epidemiological importance of classical swine fever infected, E2 sub-unit marker vaccinated animals with RT-nPCR positive blood samples [PDF]

, 2005
<p>It has been demonstrated that pigs that have been double vaccinated with an E2 sub-unit marker vaccine and that are infected with classical swine fever virus (CSFV) through a natural contact infection may react positive in a CSFV detecting RT ...
Dewulf, Jeroen, HAEGEMAN, A, KOENEN, F, KRUIF, A, Laevens, Hans, Ribbens, Stefaan   +5 more
core   +2 more sources

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Modeling Virus Transport and Removal during Storage and Recovery in Heterogeneous Aquifers [PDF]

, 2019
A quantitative understanding of virus removal during aquifer storage and recovery (ASR) in physically and geochemically heterogeneous aquifers is needed to accurately assess human health risks from viral infections.
Bradford, Scott A, Hocking, Mark, Sasidharan, Salini, Simunek, Jiri, Tazehkand, Sara S, Torkzaban, Saeed   +5 more
core  

Generation of virus-specific cytotoxic T cells in vitro II. Induction requirements with functionally inactivated virus preparations [PDF]

, 1980
Using noninfectious Sendai virus preparations after selective enzymatic digestion of either of the two viral envelope glycoproteins, it was possible to study the effect of different virion-cell membrane interactions on virus-specific cytotoxic T ...
Bosslet, Braciale, Ennis, Ertl, Ertl, Finberg, Gething, Halloran, Hapel, Homma, Hosaka, Julius, Klenk, Koszinowski, Koszinowski, Koszinowski, Levy, Palmer, Pfitzenmaier, Rosenthal, Scheid, Schrader, Shimizu, Sugamura, Sugamura, Wiktor, Zinkernagel, Zweerink   +27 more
core   +1 more source