Results 201 to 210 of about 5,701,493 (405)

No evidence for ongoing replication on ART in SIV-infected macaques

Nature Communications
The capacity of HIV-1 to replicate during optimal antiretroviral therapy (ART) is challenging to assess directly. To gain greater sensitivity to detect evolution on ART, we used a nonhuman primate (NHP) model providing precise control over the level of ...
Taina T. Immonen, Christine M. Fennessey, Leslie Lipkey, Laura Newman, Agatha Macairan, Marjorie Bosche, Nora Waltz, Gregory Q. Del Prete, Jeffrey D. Lifson, Brandon F. Keele   +9 more
doaj   +1 more source

Torque teno virus: a ubiquitous virus

Revista Brasileira de Hematologia e Hemoterapia, 2015
The TTV genome can be divided into an untranslatedregion (UTR) of 1.2kb and a potential coding region of 2.6kb.The UTR is relatively conserved, suggesting that it playsan important regulatory role in viral replication. The cod-ing region contains two large open reading frames: ORF1 andORF2.
openaire   +5 more sources

Enhancing transporter activity in heterologous expression systems with SAHA: a 2500‐times more potent and odorless alternative to butyrate

FEBS Open Bio, EarlyView.
Heterologous expression of membrane transporters in cultured cells is essential for functional characterization, but is sometimes limited by low activity. Our study compares the HDAC inhibitors butyrate, VPA and SAHA to enhance transport activity. We propose to replace butyrate by SAHA: it is equally effective, devoid of repulsive odor, costs less, and
Svenja Flögel, Maurice Tust, Samira Boussettaoui, Dietmar Fischer, Dirk Gründemann   +4 more
wiley   +1 more source

A novel approach to exploring the dark genome and its application to mapping of the vertebrate virus fossil record

Genome Biology
Background Genomic regions that remain poorly understood, often referred to as the dark genome, contain a variety of functionally relevant and biologically informative features.
Daniel Blanco-Melo, Matthew A. Campbell, Henan Zhu, Tristan P. W. Dennis, Sejal Modha, Spyros Lytras, Joseph Hughes, Anna Gatseva, Robert J. Gifford   +8 more
doaj   +1 more source

Immunisation du Porc contre la peste porcine. Emploi dans la pratique du virus lapinisé [PDF]

, 1953
P G Koopmans Marion, Pierre Goret
openalex   +1 more source

A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2–spike protein–protein interaction

Nature Biotechnology, 2020
C. Tan, W. Chia, X. Qin, Pei Liu, M. Chen, Charles Tiu, Zhiliang Hu, V. Chen, B. Young, W. Sia, Yee-Joo Tan, Randy Foo, Yongxiang Yi, D. Lye, D. Anderson, Lin‐Fa Wang   +15 more
semanticscholar   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Breakthrough Solution for Antimicrobial Resistance Detection: Surface‐Enhanced Raman Spectroscopy‐based on Artificial Intelligence

Advanced Materials Interfaces, EarlyView., 2023
This review discusses the use of Surface‐Enhanced Raman Spectroscopy (SERS) combined with Artificial Intelligence (AI) for detecting antimicrobial resistance (AMR). Various SERS studies used with AI techniques, including machine learning and deep learning, are analyzed for their advantages and limitations.
Zakarya Al‐Shaebi, Munevver Akdeniz, Awel Olsido Ahmed, Mine Altunbek, Omer Aydin   +4 more
wiley   +1 more source

A QUANTITATIVE THEORY OF INFLUENZA VIRUS HEMAGGLUTINATION-INHIBITION [PDF]

, 1953

openalex   +1 more source

Schmallenberg virus: emergence of an Orthobunyavirus among ruminants in Western Europe [PDF]

, 2012
Recently, a novel virus has been identified among ruminants in Western Europe. This virus, the so-called Schmallenberg virus, belongs to the family Bunyaviridae, genus Orthobunyavirus, serogroup Simbu and is closely related to Akabane, Aino and Shamonda ...
Bertels, Guido, Cay, Ann Brigitte, Nauwynck, Hans, Steukers, Lennert   +3 more
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