Results 211 to 220 of about 2,096,911 (224)

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

Advanced Science, EarlyView.
AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang, Li Zhang, Sen Chen, Le Xie, Yue Qiu, Chenyang Kong, Ge Yin, Weijia Kong, Yu Sun   +8 more
wiley   +1 more source

Activation of Glutamatergic Neurons in the Supramammillary Nucleus Promotes the Recovery of Consciousness under Sevoflurane Anesthesia

Advanced Science, EarlyView.
Selective lesioning of SuM glutamatergic neurons promoted the induction of and delayed emergence from sevoflurane anesthesia and increased sevoflurane sensitivity. Optogenetic stimulation of SuM glutamatergic neurons or the SuM‐MS projection promoted behavioral arousal and cortical activation under steady‐state sevoflurane anesthesia and reduced the ...
Jiayan Li, Yehui Wu, Yihan Wang, Yumin Wu, Rong Hu, Si Long, Wenqi Huang, Liming Nie, Zhongxing Wang   +8 more
wiley   +1 more source

Nanoscale warriors against viral invaders: a comprehensive review of Nanobodies as potential antiviral therapeutics. [PDF]

MAbs
Verma V, Sinha N, Raja A.
europepmc   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Microfluidic digital focus assays for the quantification of infectious influenza virus.

Lab Chip
Srimathi SR, Ignacio MA, Rife M, Tai S, Milton DK, Scull MA, DeVoe DL.   +6 more
europepmc   +1 more source

In Vitro Efficacy of Foam Hand Sanitizers Against Enveloped and Non-Enveloped Viruses. [PDF]

Food Environ Virol
Torko F, Gibson KE.
europepmc   +1 more source

Neutralizing monoclonal antibodies as effective therapeutics and prophylactics against lethal H10N7 avian influenza infection in a mouse model. [PDF]

Vet Res
Wang P, Fu J, Cheng L, Yan S, Wu H, Liu F, Yao H, Wu N, Xu L, Wu H.   +9 more
europepmc   +1 more source

Human Metapneumovirus Seasonality and Co-Circulation with Respiratory Syncytial Virus - United States, 2014-2024. [PDF]

MMWR Morb Mortal Wkly Rep
Jobe NB, Rose E, Winn AK, Goldstein L, Schneider ZD, Silk BJ.   +5 more
europepmc   +1 more source

Development of an automated plaque-counting program for the quantification of the Chikungunya virus. [PDF]

Sci Rep
Emi A, Suzuki Y, Odake C, Sakaguchi S, Wu H, Nakano T.   +5 more
europepmc   +1 more source

A positive-sense single-stranded RNA virus acquired a negative-sense open reading frame through recombination. [PDF]

PLoS Pathog
Dong X, Zhang F, Wang Y, Li C, Li X, Zhou C, Wang G, Tian Z, Gao J, Zhou H, Sui L, Nauwynck H, Sorgeloos P, Holmes EC, Huang J, Shi W.   +15 more
europepmc   +1 more source