Results 31 to 40 of about 4,195,312 (308)

Low dose influenza virus challenge in the ferret leads to increased virus shedding and greater sensitivity to oseltamivir [PDF]

, 2014
Ferrets are widely used to study human influenza virus infection. Their airway physiology and cell receptor distribution makes them ideal for the analysis of pathogenesis and virus transmission, and for testing the efficacy of anti-influenza ...
Barclay, Wendy S., Bean, Thomas J., Bruce, Christine, Carroll, Miles W., Dimmock, N. J., Dove, Brian K., Dowall, Stuart, Easton, A. J. (Andrew J.), Hallis, Bassam, Marriott, Anthony C., Newman, Edmund, Pearson, Geoff, Plank, Jenna, Rayner, Emma, Ryan, Kathryn A., Silman, Nigel J., Taylor, Irene, Whittaker, Catherine J.   +17 more
core   +2 more sources

Career development for infection and immunity research in Uganda: a decade of experience from the Makerere University – Uganda Virus Research Institute research and training programme [version 1; peer review: 2 approved]

AAS Open Research, 2020
Background: The Makerere University/Uganda Virus Research Institute (UVRI) Centre of Excellence for Infection & Immunity Research and Training (MUII) is a collaborative programme supporting excellence in Infection and Immunity (I&I) research in Uganda ...
Damalie Nakanjako, Flavia Zalwango, Pamela Wairagala, Fiona Luboga, Irene Andia Biraro, Victoria Diana Bukirwa, Mary Gorrethy Mboowa, Steve Cose, Janet Seeley, Alison Elliott   +9 more
doaj   +1 more source

Human immunodeficiency virus rebound after suppression to < 400 copies/mL during initial highly active antiretroviral therapy regimens, according to prior nucleoside experience and duration of suppression [PDF]

, 2002
This study evaluated 1433 human immunodeficiency virus (HIV)-infected patients starting highly active antiretroviral therapy (HAART), 409 (28%) of whom had prior nucleoside experience and achieved an HIV load of
Bickel, M, Doerr, HW, Johnson, MA, Klauke, S, Lampe, F, Loveday, C, Miller, V, Phillips, AN, Royal Free Ctr HIV Med Goethe Univ, Sabin, CA, Staszewski, S, Youle, MS   +11 more
core   +1 more source

Whole-genome sequence analysis reveals the circulation of multiple SARS-CoV-2 variants of concern in Nairobi and neighboring counties, Kenya between March and July 2021

Virology Journal, 2022
The emergence and rapid spread of SARS-CoV-2 variants of concern (VOC) have been linked to new waves of COVID-19 epidemics occurring in different regions of the world.
Samoel Ashimosi Khamadi, Silvanos Opanda, Samwel Lifumo Symekher, Samson Konongoi Limbaso, Solomon Langat, Josyline Kaburi Cirindi, Milkah Mwangi, Nicholas Mwikwabe, Seth Okeyo, Edith Koskei, James Mutisya, Samwel Owaka, Albert Nyunja, Hellen Koka, Meshack Wadegu, Esther Chitechi, Rachel Achilla, Janet Masitsa Majanja, Lucy Kanyara, Evans Amukoye, Wallace Bulimo   +20 more
doaj   +1 more source

‘It’s been a long haul, a big haul, but we’ve made it’: hepatitis C virus treatment in post-transplant patients with virus recurrence: An interpretative phenomenological analysis [PDF]

, 2018
The lived experience of both interferon-based and new interferon-free treatments in patients with hepatitis C virus remains understudied. To explore their journey through hepatitis C virus treatment, we interviewed seven post-transplant patients with ...
Chouliara, Zoe, Dickson, Adele, Flowers, Paul, Hayes, Peter, Krzeczkowska, Anna   +4 more
core   +3 more sources

Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano, Alexander Yelak, Walid Kaadan, Shlomo Caduri, Rivka Friedland, Orli Michaeli, Gad Dotan, Osnat Konen   +7 more
wiley   +1 more source

Molecular characterization of mumps viruses from the 2022–2023 outbreak reveals circulation of multiple genotypes in Uganda

Virology Journal
Mumps is a highly contagious viral disease caused by the mumps virus (MuV), a member of the genus Orthorubulavirus in the family Paramyxoviridae. Although effective vaccines exist, mumps vaccination is not yet part of Uganda’s routine immunization ...
Phionah Tushabe, Irene Turyahabwe, Henry Bukenya, James Peter Eliku, Francis Aine, Joseph Gaizi, Mary Nyachwo, Molly Birungi, Mayi Tibanagwa, Rena Patricia Nakyeyune, Prossy Namuwulya, Mary Bridget Nanteza, Josephine Bwogi   +12 more
doaj   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

The Zika outbreak of the 21st century. [PDF]

, 2016
The Zika virus outbreak has captivated the attention of the global audience and information has spread rapidly and wildly through the internet and other media channels.
Ansari, Aftab, Chang, Christopher, Gershwin, M Eric, Ortiz, Kristina   +3 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source