A number of viruses can initiate central nervous system (CNS) diseases that include demyelination as a major feature of neuropathology. In humans, the most prominent demyelinating diseases are progressive multifocal leukoencephalopathy, caused by JC papovirus destruction of oligodendrocytes, and subacute sclerosing panencephalitis, an invariably fatal ...
Fazakerley, JK, Walker, R
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The encephalomyocarditis virus [PDF]
The encephalomyocarditis virus (EMCV) is a small non-enveloped single-strand RNA virus, the causative agent of not only myocarditis and encephalitis, but also neurological diseases, reproductive disorders and diabetes in many mammalian species. EMCV pathogenesis appears to be viral strain- and host-specific, and a better understanding of EMCV virulence
Carocci, Margot, Bakkali, Labib
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Identification and characterization of a novel non-structural protein of bluetongue virus [PDF]
Bluetongue virus (BTV) is the causative agent of a major disease of livestock (bluetongue). For over two decades, it has been widely accepted that the 10 segments of the dsRNA genome of BTV encode for 7 structural and 3 non-structural proteins.
Rixon, F. +43 more
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The splicing factor proline-glutamine rich (SFPQ/PSF) is involved in influenza virus transcription. [PDF]
The influenza A virus RNA polymerase is a heterotrimeric complex responsible for viral genome transcription and replication in the nucleus of infected cells. We recently carried out a proteomic analysis of purified polymerase expressed in human cells and
Juan Ortín +15 more
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Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis [PDF]
Background: Influenza virus (IFV), respiratory syncytial virus (RSV), parainfluenza virus (PIV), and metapneumovirus (MPV) are the most common viruses associated with acute lower respiratory infections in young children and the elderly.
Nair, Harish, Li, You
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Tracking Virus-Specific CD4+ T Cells during and after Acute Hepatitis C Virus Infection [PDF]
Background. CD4+ T cell help is critical in maintaining antiviral immune responses and such help has been shown to be sustained in acute resolving hepatitis C.
Paul Klenerman +175 more
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Three broad modalities in the natural history of vertically acquired hepatitis C virus infection. [PDF]
BACKGROUND: Little is known about the natural history of vertically acquired hepatitis C virus (HCV) infection. METHODS: We performed a large, multicenter, prospective study of children born to HCV-infected women in Europe. Children were considered to
European Paediatric Hepatitis C. Virus Network +1 more
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Tomato marchitez virus, a new plant picorna-like virus from tomato related to tomato torrado virus [PDF]
A new virus was isolated from a tomato plant from the state of Sinaloa in Mexico. This plant showed symptoms locally known as `marchitez disease¿: severe leaf necrosis, beginning at the base of the leaflets, and necrotic rings on the fruits.
Verbeek, M. +4 more
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A significant sex--but not elective cesarean section--effect on mother-to-child transmission of hepatitis C virus infection [PDF]
BACKGROUND: Risk factors for mother-to-child transmission of hepatitis C virus (HCV) are poorly quantified. METHODS: We conducted a European multicenter prospective study of HCV-infected pregnant women and their infants.
LANARI, MARCELLO +1 more
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RNA interference targets arbovirus replication in Culicoides cells [PDF]
Arboviruses are transmitted to vertebrate hosts by biting arthropod vectors such as mosquitoes, ticks and midges. These viruses replicate in both arthropods and vertebrates and are thus exposed to different antiviral responses in these organisms.
Varela, Mariana +20 more
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