Results 121 to 130 of about 8,916,272 (292)

Influenza virus A infection of human monocyte and macrophage subpopulations reveals increased susceptibility associated with cell differentiation [PDF]

, 2012
Influenza virus infection accounts for significant morbidity and mortality world-wide. Interactions of the virus with host cells, particularly those of the macrophage lineage, are thought to contribute to various pathological changes associated with poor
Jackson David, Richard E. Randall, Richard E. Randall (190211), Nash, A.A., Anthony A Nash, Hoeve, M.A., Marieke A Hoeve, Anthony A. Nash, Hoeve Marieke A., Nash, Anthony A., Dransfield, I., Marieke A. Hoeve (190207), David Jackson (84936), Richard E Randall, Randall Richard E., Jackson, David, Randall, R.E., Nash Anthony A., David Jackson, Jackson, D., Ian Dransfield (190213), Dransfield, Ian, Marieke A. Hoeve, Anthony A. Nash (190209), Randall, Richard E., Ian Dransfield, Hoeve, Marieke A., Dransfield Ian   +27 more
core   +1 more source

TRIM26 negatively regulates interferon-β production and antiviral response through polyubiquitination and degradation of nuclear IRF3.

PLoS Pathogens, 2015
Virus infection leads to the activation of transcription factor IRF3 and subsequent production of type I inteferons, which induce the transcription of various antiviral genes called interferon stimulated genes (ISGs) to eliminate viral infection.
Peng Wang, Wei Zhao, Kai Zhao, Lei Zhang, Chengjiang Gao   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Influenza A viruses and PI3K signalling [PDF]

, 2008
The influenza A virus non-structural (NS1) protein is multifunctional, and during virus-infection NS1 interacts with several factors in order to manipulate host-cell processes.
Hale, Benjamin G.
core   +2 more sources

Activation and Inhibition of the NLRP3 Inflammasome by RNA Viruses

Journal of Inflammation Research, 2021
SK Mohiuddin Choudhury,* XuSheng Ma,* Sahibzada Waheed Abdullah, HaiXue Zheng State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture ...
Choudhury SM, Ma X, Abdullah SW, Zheng H
doaj  

Generation of a KSCBi005-A-5(TLR8KO-A10) homozygous knockout human induced pluripotent stem cell line using CRISPR/Cas9

Stem Cell Research, 2019
The Toll like Receptor (TLR) family plays an essential role in pathogen recognition and innate immunity activation. TLR8, an endosomal receptor, can recognize single-stranded RNA viruses, such as influenza virus, Sendai virus, Coxsackie B virus, HIV, and
Hyeong-jun Han, Hyo-Won Han, Hyang-Hee Seo, Jung-Hyun Kim   +3 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Inability of NS1 protein from an H5N1 influenza virus to activate PI3K/Akt signaling pathway correlates to the enhanced virus replication upon PI3K inhibition

Veterinary Research, 2012
Background Phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, activated during influenza A virus infection, can promote viral replication via multiple mechanisms.
Li Weizhong, Wang Gefei, Zhang Heng, Shen Yanqin, Dai Jianping, Wu Liqi, Zhou Jianxiang, Jiang Zhiwu, Li Kangsheng   +8 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Herpes simplex virus triggers and then disarms a host antiviral response [PDF]

, 2001
Virus infection induces an antiviral response that is predominantly associated with the synthesis and secretion of soluble interferon. Here, we report that herpes simplex virus type 1 virions induce an interferon-independent antiviral state in human ...
Smiley, J R, Macgregor, P F, Edwards, A M, Mossman, K L, Rozmus, J J, Goryachev, A B   +5 more
core   +1 more source