Results 101 to 110 of about 646,497 (314)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Glycyrrhizin exerts antioxidative effects in H5N1 influenza A virus-infected cells and inhibits virus replication and pro-inflammatory gene expression.

, 2011
Glycyrrhizin is known to exert antiviral and anti-inflammatory effects. Here, the effects of an approved parenteral glycyrrhizin preparation (Stronger Neo-Minophafen C) were investigated on highly pathogenic influenza A H5N1 virus replication, H5N1 ...
Michaelis, Martin, Sithisarn, Patchima, Leutz, Anke, Cinatl, Jindrich, Martin Michaelis, Geiler Janina, Patrizia Naczk, Geiler, Janina, Doerr, Hans Wilhelm, Naczk, Patrizia, Sithisarn Patchima, Anke Leutz, Janina Geiler, Patchima Sithisarn, Hans Wilhelm Doerr, Jindrich Cinatl, Doerr Hans Wilhelm, Naczk Patrizia, Cinatl Jindrich, Leutz Anke, Michaelis Martin   +20 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A study on the relationship between HCV NS3 and endogenous IRF-3

European Journal of Inflammation, 2018
This study aims to investigate the relationship between hepatitis C virus (HCV) NS3/4A and endogenous interferon regulatory factor-3 (IRF-3). The localization of endogenous IRF-3 protein before and after virus infection was analyzed by immunofluorescence
Hong-Ping Liang, Hotta Hak, Jian-Min Ji
doaj   +1 more source

Reshaping tumor immune microenvironment by Epstein-Barr virus activation in the stroma of colorectal cancer. [PDF]

iScience, 2023
Park HJ, Cho EJ, Kim JH, Lim S, Sung CO.
europepmc   +1 more source

In Vivo Activation of the Baboon Endogenous Virus

Experimental Biology and Medicine, 1981
AbstractActivation of humoral immune responsiveness to the baboon endogenous type C virus (BaEV) and its viral-specific envelope glycoprotein gp71, as well as activation of gp71 itself, was experimentally accomplished in baboons by inoculating fetal bovine serum (FBS) or horse serum (HS) plus Freund's complete adjuvant (FCA) or by cellular and viral ...
J W, Eichberg, S S, Kalter, R L, Heberling, D A, Lawlor, J D, Morrison, A K, Bandyopadhyay, C C, Levy, S, Yoshinoya, R M, Pope   +8 more
openaire   +2 more sources

Activation of influenza virus RNA polymerase by the 5' and 3' terminal duplex of genomic RNA

, 2003
The current model for influenza virus mRNA transcription involves the sequential interaction of the viral polymerase with the 5'- and 3'-ends of vRNA, with each RNA-protein interaction triggering a polymerase function necessary for cap-primed ...
Tiley, Laurence, Klumpp, Klaus, Digard, Paul, Lee, Michael T   +3 more
core  

Activation and modulation of antiviral and apoptotic genes in pigs infected with classical swine fever viruses of high, moderate or low virulence [PDF]

, 2009
The immune response to CSFV and the strategies of this virus to evade and suppress the pigs’ immune system are still poorly understood. Therefore, we investigated the transcriptional response in the tonsils, median retropharyngeal lymph node (MRLN), and ...
Hulst, M.M., Loeffen, W.L.A., Wit, A.A.C., de, A. A. C. de Wit, Mastebroek, B., S. V. M. Durand, W. L. A. Loeffen, Durand, S.V.M., L. Mastebroek, M. M. Hulst, de Wit, A.A.C.   +10 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

DYRK4 upregulates antiviral innate immunity by promoting IRF3 activation

EMBO Reports
Viral infection activates the transcription factors IRF3 and NF-κB, which induce type I interferon (IFN) and antiviral innate immune responses. Here, we identify dual-specific tyrosine phosphorylation-regulated kinase 4 (DYRK4) as an important regulator ...
Xianhuang Zeng, Jiaqi Xu, Jiaqi Liu, Yang Liu, Siqi Yang, Junsong Huang, Chengpeng Fan, Mingxiong Guo, Guihong Sun   +8 more
doaj   +1 more source