Results 81 to 90 of about 646,497 (314)

The Activity of Fragmented and Reassembled Tobacco Mosaic Virus [PDF]

Journal of General Microbiology, 1957
SUMMARY: Studies of the products obtained when tobacco Mosaic virus (TMV) is disrupted with alkali or phenol suggest that immunological specificity is primarily an attribute of the protein and infectivity of the nucleic acid. Although exposing the much of the nucleoprotein sedimented when preparations are ultracentrifuged at pH 6 is not infective.
Bawden, F. C., Pirie, N. W.
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Functional interactions of the Tax and p13 proteins of Human T-cell Leukemia Virus Type I [PDF]

, 2013
Human T-cell leukemia virus type 1 (HTLV-1) establishes a lifelong persistent infection in humans. Approximately 3% of the infected individuals will develop adult T-cell leukemia/lymphoma (ATLL), an aggressive malignancy of mature CD4+ T-cells. The viral
Manicone, Mariangela
core  

Some factors affecting the activation of virus preparations made from tobacco leaves infected with a tobacco necrosis virus [PDF]

, 1950
SUMMARY: Preparations of the Rothamsted tobacco necrosis virus were made by the ultracentrifugation of sap from infected tobacco leaves after a preliminary concentration by freezing. Not all the anomalous nucleoprotein in these preparations was infective,
Pirie, N. W., Bawden, F. C.
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Activation of one Tobacco Necrosis Virus by Another [PDF]

Journal of General Microbiology, 1961
SUMMARY: Preparations of the Rothamsted culture of tobacco necrosis virus always gave two and usually three zones when centrifuged in sucrose density gradients. The top zone consisted of polyhedral particles with a sedimentation constant of 50 S, the middle zone of larger polyhedral particles with 116 S, and the bottom zone when present, consisted of ...
Kassanis, B., Nixon, H. L.
openaire   +2 more sources

HIV Patients Treated with Low-dose Prednisolone Exhibit Lower Immune Activation than Untreated Patients. [PDF]

, 2012
HIV-associated general immune activation is a strong predictor for HIV disease progression, suggesting that chronic immune activation may drive HIV pathogenesis. Consequently, immunomodulating agents may decelerate HIV disease progression.
Schmidt, Barabara, Albrecht Ulmer, Norbert Donhauser, Hartwig Klinker, Scheller Carsten, Scheller, Carsten, Kasang Christa, Barbara Schmidt, Stich, August, Schmidt, Barbara, Koutsilieri, Eleni, Ulmer Albrecht, Kalluvya, Samuel, Donhauser Norbert, Koutsilieri Eleni, Kalluvya Samuel, Klinker, Hartwig, Rethwilm, Axel, Axel Rethwilm, August Stich, Schmidt Barbara, Christa Kasang, Stich August, Ulmer, Albrecht, Klinker Hartwig, Samuel Kalluvya, Carsten Scheller, Donhauser, Norbert, Rethwilm Axel, Eleni Koutsilieri, Kasang, Christa   +30 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Macrophage Activation Marker Soluble CD163 Associated with Fatal and Severe Ebola Virus Disease in Humans

Emerging Infectious Diseases, 2019
Ebola virus disease (EVD) is associated with elevated cytokine levels, and hypercytokinemia is more pronounced in fatal cases. This type of hyperinflammatory state is reminiscent of 2 rheumatologic disorders known as macrophage activation syndrome and ...
Anita K. McElroy, Punya Shrivastava-Ranjan, Jessica R. Harmon, Roosecelis B. Martines, Luciana Silva-Flannery, Timothy D. Flietstra, Colleen S. Kraft, Aneesh K. Mehta, G. Marshall Lyon, Jay B. Varkey, Bruce S. Ribner, Stuart T. Nichol, Sherif R. Zaki, Christina F. Spiropoulou   +13 more
doaj   +1 more source