Results 81 to 90 of about 615,631 (266)
A study on the relationship between HCV NS3 and endogenous IRF-3
European Journal of Inflammation, 2018 This study aims to investigate the relationship between hepatitis C virus (HCV) NS3/4A and endogenous interferon regulatory factor-3 (IRF-3). The localization of endogenous IRF-3 protein before and after virus infection was analyzed by immunofluorescence
Hong-Ping Liang, Hotta Hak, Jian-Min Ji
doaj +1 more source
Reshaping tumor immune microenvironment by Epstein-Barr virus activation in the stroma of colorectal cancer. [PDF]
iScience, 2023 Park HJ, Cho EJ, Kim JH, Lim S, Sung CO.
europepmc +1 more source
In Vivo Activation of the Baboon Endogenous Virus
Experimental Biology and Medicine, 1981 AbstractActivation of humoral immune responsiveness to the baboon endogenous type C virus (BaEV) and its viral-specific envelope glycoprotein gp71, as well as activation of gp71 itself, was experimentally accomplished in baboons by inoculating fetal bovine serum (FBS) or horse serum (HS) plus Freund's complete adjuvant (FCA) or by cellular and viral ...
J W, Eichberg +8 more
openaire +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
DYRK4 upregulates antiviral innate immunity by promoting IRF3 activation
EMBO ReportsViral infection activates the transcription factors IRF3 and NF-κB, which induce type I interferon (IFN) and antiviral innate immune responses. Here, we identify dual-specific tyrosine phosphorylation-regulated kinase 4 (DYRK4) as an important regulator ...
Xianhuang Zeng +8 more
doaj +1 more source
The role of phospholipase C signaling in bovine herpesvirus 1 infection
Veterinary Research, 2017 Bovine herpesvirus 1 (BoHV-1) infection enhanced the generation of inflammatory mediator reactive oxidative species (ROS) and stimulated MAPK signaling that are highly possibly related to virus induced inflammation.
Liqian Zhu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
SPINK6 inhibits human airway serine proteases and restricts influenza virus activation. [PDF]
EMBO Mol Med, 2022 Wang D +15 more
europepmc +1 more source
An active foamy virus integrase is required for virus replication.
Journal of General Virology, 1999 Foamy viruses (FVs) make use of a replication strategy which is unique among retroviruses and shows analogies to hepadnaviruses. The presence of an integrase (IN) and obligate provirus integration distinguish retroviruses from hepadnaviruses. To clarify whether a functional IN is required for FV replication, a mutant in the highly conserved DD35E motif
Enssle, J. +7 more
openaire +3 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source