Results 111 to 120 of about 124,032 (305)

Hierarchically Engineered Multi‐Enzyme Nanoreactors for in vitro Drug Biosynthesis and Pathway Transplantation Into Cells

Advanced Materials, EarlyView.
A hierarchically structured metal–organic framework (eMIL) is shown to host the complete six‐enzyme biosynthesis pathway for the anti‐cancer pigment violacein, reshaping reaction dynamics and multiplying in vitro yields. eMIL nanoreactors deliver this reconstituted bacterial multi‐protein system into mammalian cells, where cell‐derived substrates and ...
Ainur Sharip, Somayah S. Qutub, Manar M. Farooqui, Walaa Baslyman, Nida Khalfay, Lukman O. Alimi, Patricia Lopez Sanchez, Lingyun Zhao, Milena Chernyshevskaia, Giovanni Colombo, Niveen M. Khashab, Stefan T. Arold, Raik Grünberg   +12 more
wiley   +1 more source

Pneumonia, influenza virus A (H1N1) and atypical evolution in the Intensive Care Unit

Acta Médica del Centro, 2014
It is presented a patient of 50 years old, atypical in its evolution and its complications, he was hospitalized in February 2014 in the Intensive Care Unit of the  "Arnaldo Milian Castro"Surgical Hospital, City of Santa Clara, Villa Clara Province.
Francisco Cordié Muñoz, Wilder Reinoso Fernández, Sailys Rodríguez López   +2 more
doaj  

RIESGO DE INFECCIÓN EN HUMANOS A LA EXPOSICIÓN DEL VIRUS DE INFLUENZA AVIAR EN CHILE

Medwave
Introducción En Chile en diciembre de 2022 se describió el primer hallazgo de aves marítimas silvestres positivos a Influenza Aviar Altamente Patogénica (IAAP) (H5N1), inicialmente en las regiones de Arica y Parinacota, Tarapacá, Antofagasta y que durante el 2023 se extendió por todo el territorio nacional.
María Fernanda Olivares Barraza, Paula Camila Rodriguez Ferrari, María José Castro Muñoz, Catalina Francisca Hernandez Martinez, Doris Ximena Gallegos Ulloa, Cristina Viviana Sotomayor Proschle, Vallebuona Stagno, Christian Garcia Calavaro, Jose Emilio Villarroel de la Sotta   +8 more
openaire   +1 more source

Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation

Advanced Science, EarlyView.
Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater, Savvas Kourtis, Camilla Reiter Elbæk, Lorena Espinar, Carolina Toro‐Márquez, Albert Coll‐Manzano, Alfredo Smiriglia, Laura García‐López, Laura Wiegand, Maria Guirola, Frédéric Fontaine, Andrea Morandi, André C. Müller, Sara Sdelci   +13 more
wiley   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Comparación entre las infecciones por influenza A (H1N1) y por influenza estacional en pacientes hospitalizados durante epidemia en el 2009

Revistas Argentina de Medicina, 2015
Introducción En abril de 2009 se informó de un brote de influenza A (H1N1), y en mayo en Argentina. Comparamos pacientes con influenza A (H1N1) e influenza estacional (IE).
Micaela Schiaffino, Bruno L Ferreyro, Vanina E Wainsztein, Nora Fuentes, Cristina Elizondo, Diego H Giunta, Luis Cámera, Florencia Cahn, Astrid Smud, Javier Altclas, Claudia Salgueira, Pablo Desmery, José Malvido, Beatriz Livellara, Gabriel Waisman, Laura Barcán   +15 more
doaj   +2 more sources

IL‐3 Modulates Microglia Polarization and Attenuates Neuroinflammation in Traumatic Brain Injury

Advanced Science, EarlyView.
IL‐3 recruits PRDX1 through IL‐3R to modulate the inflammatory response of microglia via the KEAP1‐NRF2‐HO‐1/NF‐κB pathway to attenuate neuroinflammation in traumatic brain injury. ABSTRACT Microglia play a crucial role in the progression of neuroinflammation following traumatic brain injury (TBI). Interleukin‐3 (IL‐3), a significant regulatory factor,
Nana Huang, Qingchen Zhang, Yanrui Chen, Dapeng Yu, Ronghan Liu, Jianning Kang, Xiang Fang, Ying Zhang, Hong Bian, Yanxin Zhao, Yongcheng Yin, Ce Zhang, Yanfei Jia, Qingfa Chen, Yuepeng Fang, Shang Li, Fang Li, Zhengxin Jin, Bin Ning   +18 more
wiley   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

ANÁLISIS DEL MODELO NORMATIVO DE PREVENCIÓN SANITARIA DE INFLUENZA AVIAR EN COLOMBIA

Revista de la Facultad de Ciencias Agropecuarias, 2019
La influenza aviar es la enfermedad causada por la infección del virus de la familia Orthomixoviridae, género Influenza virus A, encontrándose de forma natural entre las aves acuáticas de todo el mundo y puede infectar a las aves de corral domésticas y a
Beatriz Elena Patiño Quiroz, Nicolas Ernesto Baldrich Romero, Sebastian Duque Patiño   +2 more
doaj  

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source