Results 121 to 130 of about 143,533,111 (301)
Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress
Advanced Science, EarlyView.Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen +11 more
wiley +1 more source
Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS) in Glioblastoma
Advanced Science, EarlyView.ABSTRACT Glioblastoma (GBM) remains one of the most challenging brain malignancies due to the restrictive nature of the blood–brain barrier (BBB), which severely limits effective drug and gene delivery. To overcome this, we introduce Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS), a modular platform that enables safe ...
Gulsah Erel‐Akbaba +25 more
wiley +1 more source
La dimérisation, une nouvelle propriété de l’ARN polymérase des virus influenza [PDF]
médecine/sciences, 2020 Catherine Isel +2 more
openaire +1 more source
The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm [PDF]
, 2013 The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here we show that a pre-existing antiviral state inhibits replication of influenza A viruses in human A549 cells by ...
Xiao, Han +6 more
core +1 more source
Advanced Science, EarlyView.Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu +8 more
wiley +1 more source
La influenza A (H1N1): estado actual del conocimiento Influenza A (H1N1) virus: current information
Revista de Ciencias Médicas de Pinar del Río, 2010 Se revisó la bibliografía actualizada sobre el tema a partir de los principales buscadores, y reuniones internacionales realizadas sobre la pandemia de la influenza A (H1N1).
Laura Margarita González Valdés +2 more
doaj
Implantación de la proteína PB1-F2 en la patogenicidad del virus de la influenza porcina
, 2013 Cada año, las epidemias de gripe causan enfermedad respiratoria severa a entre cinco y treinta millones de personas y fallecen entre doscientas cincuenta mil y medio millón en todo el mundo. En 1918, la pandemia de la llamada “gripe española”, provocó la muerte de al menos cincuenta millones de personas.
openaire +2 more sources
Advanced Science, EarlyView.Radioresistance arises partly from tumor cells evading cuproptosis via unknown defenses. This study reveals that the PRMT5‐VPS34 axis acts as a radiation‐activated anticuproptotic mechanism: PRMT5 methylates VPS34 at Arg174, recruiting USP10 to remove K48‐linked ubiquitination and prevent degradation.
Wei Chen +17 more
wiley +1 more source
Factores asociados a mortalidad en la pandemia de influenza H1N1 2009 en Paraguay
Memorias del Instituto de Investigaciones en Ciencias de la Salud, 2011 La presencia de condiciones médicas pre-existentes se ha asociado con la mortalidad relacionada al virus de influenza A (H1N1). El objetivo de este estudio fue determinar los factores asociados a mortalidad en personas con sospecha de infección con ...
Agueda Caballero +6 more
doaj
Advanced Science, EarlyView.Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta +10 more
wiley +1 more source