Results 121 to 130 of about 43,232 (314)
Advanced Science, EarlyView.Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang +18 more
wiley +1 more source
Influenza: agente etiológico, manifestaciones, diagnóstico, prevención y control
Revista de la Facultad de Medicina, 1999 La influenza es una entidad infectocontagiosa causada por un virus cubierto de 80 a 120 nm de diámetro con cápside de simetría helicoidal, que pertenece a la familia Orthomyxoviridae .Ya que todos los subtipos de influenza A existen en aves acuáticas ...
Manuel Antonio Vargas Córdoba
doaj
Advanced Science, EarlyView.Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang +9 more
wiley +1 more source
Revista Peruana de Medicina Experimental y Salud Pública, 2004 Objetivo: Identificar el virus influenza y otros agentes etiológicos relacionados con la presentación de síndrome febril en los departamentos de Piura, Tumbes, Lambayeque y La Libertad, en mayo de 2001.
Yvonne Torres de Yon +4 more
doaj
Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors
Advanced Science, EarlyView.Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen +8 more
wiley +1 more source
Advanced Science, EarlyView.This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong +6 more
wiley +1 more source
Acta Médica Peruana, 2010 Objetivo: Conocer el perfil epidemiológico y clínico de los casos confirmados de influenza A H1N1 en pacientes atendidos entre julio del 2009 y febrero del 2010 en el Hospital Nacional Almanzor Aguinaga Asenjo - EsSALUD, Red Asistencial Lambayeque ...
Cristian Díaz Vélez +3 more
doaj
, 2017 Los subtipos H1N1, H3N2 y H1N2 del virus de influenza A porcina afectan a las poblaciones de cerdos en todo el mundo y representan un factor de riesgo en la economía de las granjas porcícolas y en la salud humana.
openaire +1 more source
The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation
Advanced Science, EarlyView.ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley +1 more source