Results 181 to 190 of about 28,539 (272)

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

Advanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang, Fang Li, Jiao Liu, Shu‐Ang Li, Dan‐Hua Liu, Zhuanbin Wu, Pei‐Pei Liu, Wenju Liu, Bin Zhou, Cizhong Jiang, Haibing Zhang, Ying Yu, Jian‐Sheng Kang   +12 more
wiley   +1 more source

Impact of Nirsevimab on RSV and Non-RSV Severe Respiratory Infections in Hospitalized Infants. [PDF]

Influenza Other Respir Viruses
García-García ML, Alonso-López P, Alcolea S, Arroyas M, Pozo F, Casas I, Iglesias-Caballero M, Sánchez-León R, Hurtado-Gallego J, Calvo C.   +9 more
europepmc   +1 more source

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Advanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He, Si Xu, Mengdi Li, Hui Li, Shaolan Li, Li Niu, Honghua Song, Rixin Cai, Yue Zhou, Zhilong Cao, Yingjie Wang, Yongjun Wang   +11 more
wiley   +1 more source

Virus de la influenza: prevalencia, respuesta inmunitaria y pruebas de diagnóstico en la población infantil

Cindy Elizabeth Muentes-Bailón, Carmen Alexandra Suarez Quimis, Javier Martín Reyes-Baque   +2 more
openalex   +2 more sources

CXCL13 Expression Promotes CAR T Cell Antitumor Activity and Potentiates Response to PD‐1 Blockade

Advanced Science, EarlyView.
This study demonstrates that engineering CAR T cells to express CXCL13 enhances their antitumor efficacy and significantly improves responsiveness to PD‐1 immune checkpoint blockade. CXCL13 promotes T cell persistence, and resistance to early exhaustion via the AKT‐mTOR pathway.
Yang Zhou, Wenli Zhao, Yihan Zhu, Hongyan Liu, Yicheng Sun, Zhengrong Gong, Xuanyi Li, Ziying Liu, Kang Wen, Yicheng Wang, Jie Ren, Ruipei Xiao, Ling Jiang, Yanfeng Hu, Enguang Bi, Xiaoyong Zhang   +15 more
wiley   +1 more source

Promising Effects of Duck Vaccination against Highly Pathogenic Avian Influenza, France, 2023-2024. [PDF]

Emerg Infect Dis
Guinat C, Fourtune L, Lambert S, Martin E, Gerbier G, Pellicer AJ, Guérin JL, Vergne T.   +7 more
europepmc   +1 more source

Coinfecciones virales respiratorias: una revisión sistemática sobre SARS CoV-2, Virus de la Influenza, Virus Respiratorio Sincitial

Vanessa Hidalgo Pérez, Ricardo Recalde-Navarrete   +1 more
openalex   +2 more sources

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

Advanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song, Xiaokai Zhang, Zihang Huang, Zhiqiang Pei, Linqi Zeng, Fengze Cai, Tongyao Wang, Mohan Li, Chenyan Liu, Yining Song, Jiahao Guo, Hao Lu, Xinyu Weng, Li Shen, Xiaochun Zhang, Xingxing Cai, Aijun Sun, Junbo Ge   +17 more
wiley   +1 more source

Immunity Awareness-Strategies to Improve the Degree of Acceptance of Vaccines: A Systematic Review. [PDF]

Vaccines (Basel)
Martínez-Serrano A, Pulido-Fuentes M, Notario-Pacheco B, Palmar-Santos AM, Cobo-Cuenca AI, Díez-Fernández A.   +5 more
europepmc   +1 more source

RIESGO DE INFECCIÓN EN HUMANOS A LA EXPOSICIÓN DEL VIRUS DE INFLUENZA AVIAR EN CHILE

María Fernanda Olivares Barraza, Paolo Ferrari, M. Muñoz, C. Martínez, Díaz Ulloa, Cristina Viviana Sotomayor Proschle, Vallebuona Stagno, Christian García, Jose Emilio Villarroel de la Sotta   +8 more
openalex   +1 more source