Results 211 to 220 of about 43,232 (314)

Interim Effectiveness Estimates of 2025 Southern Hemisphere Influenza Vaccines in Preventing Influenza-Associated Outpatient and Hospitalized Illness - Eight Southern Hemisphere Countries, March-September 2025. [PDF]

MMWR Morb Mortal Wkly Rep
Russ S, Nogareda F, Regan AK, Benedetti E, Pasinovich M, Voto C, Chilver M, Stocks N, Sullivan SG, Cheng AC, Blyth CC, Hassall J, de Almeida WAF, de Paula Júnior FJ, de Melo Araújo AC, Vergara N, Rodríguez Ferrari PC, Fasce RA, Saavedra C, Penayo E, Gómez S, Domínguez C, Anglemyer A, Wood T, Huang QS, Walaza S, Zwane P, Wolter N, Goñi N, Tairovich J, Silvera E, Couto P, Jara J, Kondor RJ, Azziz-Baumgartner E, Chard AN.   +35 more
europepmc   +1 more source

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

Advanced Science, EarlyView.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li, Chang Liu, Zhaoxue Ma, Dongyou Zheng, Renkai Wang, Yongjing Yu, Guangmin Chen, Chenglong Li, Yue Bu, Hang Cao, Bing Zhang   +10 more
wiley   +1 more source

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

Editorial: Emerging concepts for respiratory viruses after the pandemic. [PDF]

Front Cell Infect Microbiol
Dimopoulou D, Skevaki C, Can F, Morfin-Sherpa F, Fragkou PC.   +4 more
europepmc   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

Highly Conserved Influenza A Nucleoprotein as a Target for Broad-Spectrum Intervention: Characterization of a Monoclonal Antibody with Pan-Influenza Reactivity. [PDF]

Vet Sci
Liu J, Gao W, Zhao K, Huang Z, Liu L, Chang J, Cao X, Zhou W, Zhou X, Liu Y, Li X, Song Y.   +11 more
europepmc   +1 more source

RPS3‐Enriched Extracellular Vesicles Mediate Liver‐Spinal Cord Inter‐Organ Communication

Advanced Science, EarlyView.
Spinal cord injury activates the liver to send extracellular vesicles loaded with RPS3 protein to the lesion site. These vesicles are taken up by neural stem cells and astrocytes, triggering NF‐κB signaling, impairing the regeneration of neurons and myelin, and promotes harmful inflammation, ultimately hindering recovery.
Peiwen Song, Zuomeng Wu, Yixiang Dong, Yunxiong Fang, Shiyu Bian, Daokuan Wang, Huang Fang, Yunlei Liu, Wang Ying, Jun Qian, Tianyu Han, Cailiang Shen   +11 more
wiley   +1 more source

Development of cell combos micromethod to isolate respiratory viruses not detected by molecular techniques. [PDF]

Microbiol Spectr
Valade M, Le Bideau M, Grimaldier C, Boschi C, Colson P, La Scola B.   +5 more
europepmc   +1 more source

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source

Impact of naturally occurring hemagglutinin substitutions on antigenicity and fitness of influenza A(H5N1) virus. [PDF]

Npj Viruses
Wang L, Hatta M, Feng C, Carney P, Almanzar-Jordan MR, Wang J, Hossain J, Atteberry G, Assad-Garcia N, Sheffield S, DaSilva J, De La Cruz JA, Hatta Y, Johnson MC, Frederick J, Hart R, Lacek KA, Wilson M, Keong LM, Lin X, Huang Y, Currier M, Tan G, Vashee S, Dugan VG, Rambo-Martin B, Di H, Kirby MK, Davis CT, Stevens J, Zhou B.   +30 more
europepmc   +1 more source