Results 231 to 240 of about 124,032 (305)

Wild birds drive the introduction, maintenance, and spread of H5N1 clade 2.3.4.4b high pathogenicity avian influenza viruses in Spain, 2021-2022. [PDF]

Virus Evol
Cho AY, Lee DH, Fusaro A, Giussani E, Pastori A, Agüero M, Majó N, Bertran K.   +7 more
europepmc   +1 more source

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

Real-time prediction of influenza and respiratory syncytial virus epidemics in primary care using the Gompertz model. [PDF]

Sci Rep
Perramon-Malavez A, Ye Q, López D, Montañola-Sales C, Alonso S, Álvarez E, Soriano-Arandes A, Prats C.   +7 more
europepmc   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

[Acute Flacid Paralysis and Encephalitis: A Deadly Combination. Report of the Latest Case of Human Rabies in Colombia: A Reminder of a Preventable Enemy]. [PDF]

Rev Neurol
García Jimenez FA, Valencia-Rey PA, Tutalchá Oviedo K, Mejía López S, Arango Viana JC, Cuartas Ramírez JD.   +5 more
europepmc   +1 more source

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

Divergent macrophage responses to Influenza A virus and <i>Streptococcus pneumoniae</i>: co-infection drives bacterial dominance whereas superinfection favors viral priming. [PDF]

Front Immunol
Arranz-Herrero J, Baranda J, Rius-Rocabert S, Moreno-Vadillo M, Gonzalez-Ruiz I, Miranda-Bedate A, Pinelli E, Inchausti-Moya I, Izpura-Luis S, Tur-Planells V, Reche P, Fernandez P, Revilla Y, Del Real G, García-Sastre A, Gutiérrez-Martín CB, Ochando J, Nistal-Villan E.   +17 more
europepmc   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Influenza virus infection drives upregulation of CD84 across a broad range of immune cells. [PDF]

Clin Transl Immunology
Jia X, Foo IJ, McQuilten HA, Crawford JC, Cabug AF, Gebregzabher D, Chou J, Mettelman RC, Novak T, Van de Velde LA, Thwaites RS, Randolph AG, Thomas PG, Xu J, Wang Z, Kedzierska K, Kedzierski L, Chua BY.   +17 more
europepmc   +1 more source