Results 251 to 260 of about 143,533,111 (301)

Favipiravir tissue distribution and inhibitory quotients in preclinical models: towards a pipeline for evidence-based antiviral repurposing. [PDF]

J Antimicrob Chemother
Petit PR, Touret F, Driouich JS, Paré A, de Lamballerie X, Marlin R, Contreras V, Relouzat F, Gallouët AS, Pascal Q, Guedj J, Le Grand R, Nougairède A, Solas C.   +13 more
europepmc   +1 more source

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Respiratory infectious diseases in intensive care units’ patients during 2024, in two hospitals in Guayaquil, Ecuador [PDF]

Biomedica
Sánchez-Amador F, Merejildo M, Solórzano L, Bedoya C, Luzuriaga F, Alvarado J, Miranda M, Alvarado X.   +7 more
europepmc   +1 more source

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Severe Respiratory Illness and Death Associated with Outbreak of Human Rhinovirus B14 among Older Adults, France, 2024. [PDF]

Emerg Infect Dis
Andreani J, Boschi C, Decoppet A, Delerce J, Penant G, Karadeniz A, Grimaldier C, Jardot P, Zangoli L, Mandy M, Vigroux N, Polesso F, Edouard S, Cano P, Lagier JC, La Scola B, Colson P.   +16 more
europepmc   +1 more source

Pathogen-specific immune responses might underlie divergent outcomes of coronavirus and influenza infection in the natural porcine host. [PDF]

Commun Biol
Sedaghat-Rostami E, Yang L, Vats A, Paudyal B, Briggs E, Carr BV, Freimanis G, Ruedas-Torres I, Downing T, Rollier C, Marougka K, De Haan CAM, Mehat J, La Ragione R, Muir A, Richard AC, Van Reeth K, Salguero FJ, Gerner W, Tchilian E.   +19 more
europepmc   +1 more source

Respiratory Viral Co-Infections in SARS-CoV-2 Positive Patients in Burkina Faso: A Cross-Sectional Study. [PDF]

Health Sci Rep
Kaboré BWO, Gouba N, Ilboudo AK, Cissé A, Lingani M, Sawadogo C, Ouédraogo EW, Ouoba JB, Savadogo M, Tarnagda Z.   +9 more
europepmc   +1 more source

Caracterización de una vacuna recombinante contra el virus de la influenza

, 2014
openaire   +1 more source

Reassortant High Pathogenicity Avian Influenza A(H5N1) Viruses During the Reemergence in Uruguay Suggest Increasing Genetic Diversity in South America. [PDF]

Viruses
Marandino A, Tomás G, Panzera Y, Uriarte V, Russi V, Pérez R, Bassetti L, Negro R, Rodríguez S, Pérez R.   +9 more
europepmc   +1 more source