Results 51 to 60 of about 1,696,022 (297)

Colorimetric reverse transcription loop-mediated isothermal amplification assay for visual, sensitive, and specific detection of enterovirus G

BMC Veterinary Research
Background Enterovirus G (EV-G) is widely prevalent in pigs worldwide, and co-infections of EV-G and other diarrhea-causing pathogens have been reported in many countries, threatening the pig farming industry.
Zhan-hong Li, Zhen-xing Zhang, Pei Zhu, Zhuo-ran Li, Peng Liu, Qi Yang, Qiu-yan Yang, Zhen Yang, Jian-ling Song   +8 more
doaj   +1 more source

Development of a simplified RT-PCR without RNA isolation for rapid detection of RNA viruses in a single small brown planthopper (Laodelphax striatellus Fallén)

Virology Journal, 2017
Background The small brown planthopper (SBPH) is an important pest of cereal crops and acts as a transmission vector for multiple RNA viruses. Rapid diagnosis of virus in the vector is crucial for efficient forecast and control of viral disease.
Qiufang Xu, Haoqiu Liu, Pingping Yuan, Xiaoxia Zhang, Qingqing Chen, Xuanli Jiang, Yijun Zhou   +6 more
doaj   +1 more source

Versatile live-attenuated SARS-CoV-2 vaccine platform applicable to variants induces protective immunity

iScience, 2022
Summary: Live-attenuated vaccines are generally highly effective. Here, we aimed to develop one against SARS-CoV-2, based on the identification of three types of temperature-sensitive (TS) strains with mutations in nonstructural proteins (nsp), impaired ...
Akiho Yoshida, Shinya Okamura, Shiho Torii, Sayuri Komatsu, Paola Miyazato, Hitomi Sasaki, Shiori Ueno, Hidehiko Suzuki, Wataru Kamitani, Chikako Ono, Yoshiharu Matsuura, Shiro Takekawa, Koichi Yamanishi, Hirotaka Ebina   +13 more
doaj   +1 more source

Immunodeficiencies caused by infectious diseases. [PDF]

, 2010
Immunodeficiencies caused by infectious agents may result from disruption of normal host barriers or dysregulation of cellular immunity, the latter serving to promote survival of the infectious agent through immune evasion.
Sykes, Jane
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Modernising epidemic science: enabling patient-centred research during epidemics [PDF]

, 2016
Background: Emerging and epidemic infectious disease outbreaks are a significant public health problem and global health security threat. As an outbreak begins, epidemiological investigations and traditional public health responses are generally mounted ...
Horby, Peter W., Rojek, Amanda M.
core   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Limited impact of hepatitis A virus 3C protease-mediated cleavage on the functions of NEMO in human hepatocytes

Journal of Virology
NF-κB essential modulator (NEMO) is critically involved in the induction of interferons (IFNs) and pro-inflammatory cytokines. Hepatitis A virus (HAV) 3C protease was recently identified to cleave NEMO in non-hepatic cells.
Hao-En Huang, Ombretta Colasanti, Teng-Feng Li, Volker Lohmann   +3 more
doaj   +1 more source

IgA polymerization contributes to efficient virus neutralization on human upper respiratory mucosa after intranasal inactivated influenza vaccine administration

Human Vaccines & Immunotherapeutics, 2018
Unlike the current injectable influenza vaccines, intranasally administered influenza vaccines induce influenza virus-specific IgA antibodies in the local respiratory mucosa as well as IgG antibodies in the systemic circulation. Our previous study showed
Yoshihiko Terauchi, Kaori Sano, Akira Ainai, Shinji Saito, Yuki Taga, Kiyoko Ogawa-Goto, Shin-ichi Tamura, Takato Odagiri, Masato Tashiro, Mikiya Fujieda, Tadaki Suzuki, Hideki Hasegawa   +11 more
doaj   +1 more source

Knowledge and practices related to plague in an endemic area of Uganda

International Journal of Infectious Diseases, 2017
Background: Plague is a virulent zoonosis reported most commonly from Sub-Saharan Africa. Early treatment with antibiotics is important to prevent mortality. Understanding knowledge gaps and common behaviors informs the development of educational efforts
Kiersten J. Kugeler, Titus Apangu, Joseph D. Forrester, Kevin S. Griffith, Gordian Candini, Janet Abaru, Jimmy F. Okoth, Harriet Apio, Geoffrey Ezama, Robert Okello, Meghan Brett, Paul Mead   +11 more
doaj   +1 more source