Results 61 to 70 of about 1,696,022 (297)

High prevalence of bronchiectasis is linked to HTLV-1-associated inflammatory disease. [PDF]

, 2015
BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1), a retrovirus, is the causative agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukaemia/lymphoma (ATLL).
A Gessain, A Gessain, AH Smith, AM Vine, CR Bangham, D Weycker, E Gotuzzo, EL Murphy, F Okada, Graham P Taylor, H Kawai, H Merle, H Nakamura, IARC Monographs on the Evaluation of Carcinogenic Risk to Humans, J Crofton, JR Orland, K Nishioka, L Einsiedel, L Einsiedel, L Einsiedel, L LaGrenade, M Nagai, M Nakagawa, M Osame, M Sugimoto, M Sugimoto, MA Demontis, MG Flynn, OS Morgan, PJ McShane, S Mita, S Mori, Shohreh Honarbakhsh, T Arakaki, T Kondo, T Matsuda, T Yamashiro, W Matsuyama   +37 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

48 weeks outcome after cessation of nucleos(t)ide analogue therapy in chronic hepatitis B patients

Annals of Hepatology, 2020
Introduction and objective: The aim of the present study was to investigate the significance of serum HBsAg levels in treatment cessation of nucleoside analogues (NAs) in patients with chronic hepatitis B (CHB) infection.
Li Gao, Yue Hu, Xiaofeng Shi, Xin Li, Dazhi Zhang, Hong Ren   +5 more
doaj   +1 more source

Public Health Threat of New, Reemerging, and Neglected Zoonoses in the Industrialized World [PDF]

, 2010
Microbiologic infections acquired from animals, known as zoonoses, pose a risk to public health. An estimated 60% of emerging human pathogens are zoonotic. Of these pathogens, >71% have wildlife origins.
Cutler, S.J., Fooks, A.R., Poel, W.H.M., van der   +2 more
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

A meta-analysis of the antiviral activity of the HBV-specific immunotherapeutic TG1050 confirms its value over a wide range of HBsAg levels in a persistent HBV pre-clinical model

Human Vaccines & Immunotherapeutics, 2018
Pre-clinical models mimicking persistent hepatitis B virus (HBV) expression are seldom, do not capture all features of a human chronic infection and due to their complexity, are subject to variability.
Roland Kratzer, Benoît Sansas, Karine Lélu, Alexei Evlachev, Doris Schmitt, Nathalie Silvestre, Geneviève Inchauspé, Perrine Martin   +7 more
doaj   +1 more source

Metagenomic screening of the sugarcane virome in Florida. [P.36] [PDF]

, 2015
Viral metagenomics has revolutionized the way pathologists decipher viral diseases. While the impact of this new approach is still debatable in plant virus diagnostics, viral metagenomics has already produced key advances in viral ecology and has the ...
Comstock, Jack C., ElSayed, Abdelaleim, Fernandez, Emmanuel, Filloux, Denis, Rott, Philippe, Roumagnac, Philippe   +5 more
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Analysis of host factor networks during hepatitis B virus infection in primary human hepatocytes

Virology Journal
Background Chronic hepatitis B virus (HBV) infection affects around 250 million people worldwide, causing approximately 887,000 deaths annually, primarily owing to cirrhosis and hepatocellular carcinoma (HCC).
Suhyun Hwangbo, Gahee Kim, Yongwook Choi, Yong Kwang Park, Songmee Bae, Jae Yong Ryu, Wonhee Hur   +6 more
doaj   +1 more source

Evidence for Oxidative Stress in Experimental Prion Disease

Neurobiology of Disease, 2000
Oxidative stress has been shown to be important in several neurodegenerative disorders. Previous in vitro studies have already demonstrated the ability of a prion protein fragment to induce oxidative stress in cultured cells.
Marin Guentchev, Till Voigtländer, Christine Haberler, Martin H. Groschup, Herbert Budka   +4 more
doaj   +1 more source