Results 41 to 50 of about 1,501,773 (255)

Mating ecology explains patterns of genome elimination [PDF]

, 2014
This research has been supported by a Royal Society University Research Fellowship (AG), a Royal Society Newton International Fellowship (LR) and two NERC Independent Research Fellowships (AG & LR).Genome elimination – whereby an individual discards ...
Ross, Laura, Gardner, Andy
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Can economic analysis contribute to disease elimination and eradication? : A systematic review [PDF]

, 2015
BACKGROUND: Infectious diseases elimination and eradication have become important areas of focus for global health and countries. Due to the substantial up-front investments required to eliminate and eradicate, and the overall shortage of resources for ...
Sicuri, E, Evans, David B., Tediosi, F., Elisa Sicuri, Sicuri, Elisa, Tediosi, F, Fabrizio Tediosi (247282), Evans, David B, Evans David B., David B Evans, Sicuri Elisa, Sicuri, E., David B. Evans (569557), Evans, DB, Tediosi Fabrizio, Tediosi, Fabrizio, Evans, D. B., Fabrizio Tediosi, Elisa Sicuri (247271)   +18 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Hepatitis C virus evasion mechanisms from neutralizing antibodies [PDF]

, 2011
Hepatitis C virus (HCV) represents a major public health problem, affecting 3% of the world’s population. The majority of infected individuals develop chronic hepatitis, which can progress to cirrhosis and hepatocellular carcinoma.
Angus, Allan G.N., Arvind H. Patel, Patel, Arvind H., Caterina Di Lorenzo, Allan G. N. Angus, Lorenzo, Caterina D.   +5 more
core   +1 more source

Efficacy of Plant Tissue Culture Techniques for Eliminating Black Mulberry Idaeovirus (BMIV) from Infected Black Mulberry (Morus nigra)

Plants
Obtaining virus-free plants is a crucial step in disease management that enables reliable and profitable fruit farming. The present study applied various in vitro virus elimination protocols, including apical shoot culture, chemotherapy, thermotherapy ...
Doaa Waseem Abdelwahab Elansary, Kahraman Gürcan, Vahid Roumi, Özhan Şimşek   +3 more
doaj   +1 more source

Effect of pre-culture on virus elimination from in vitro apple by thermotherapy coupled with shoot tip culture

Journal of Integrative Agriculture, 2018
We evaluated the role of pre-culture on survival rate of in vitro apple plants treated by thermotherapy. Two apple cultivars, Malus×domestica cv. Pink Lady and Huafu, were used in the experiment and both have widely grown in China and infected with Apple
Guo-jun HU, Ya-feng DONG, Zun-ping ZHANG, Xu-dong FAN, Fang REN, Zheng-nan LI   +5 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Financial and economic costs of the elimination and eradication of onchocerciasis (river blindness) in Africa [PDF]

, 2015
Onchocerciasis (river blindness) is a parasitic disease transmitted by blackflies. Symptoms include severe itching, skin lesions, and vision impairment including blindness. More than 99% of all cases are concentrated in sub-Saharan Africa.
Sicuri, E, Young Eun Kim (117995), Elisa Sicuri, Sicuri, Elisa, Tediosi, F, Fabrizio Tediosi (247282), Young Eun Kim, Tediosi, Fabrizio, Young Eun Kim, Fabrizio Tediosi, Kim, Young E., Elisa Sicuri (247271), Kim, YE, Kim, Young Eun   +13 more
core   +2 more sources