Results 61 to 70 of about 138,634 (297)

Immune-checkpoint expression in Epstein-Barr virus positive and negative plasmablastic lymphoma: a clinical and pathological study in 82 patients

Haematologica, 2016
Plasmablastic lymphoma is a rare and aggressive diffuse large B-cell lymphoma commonly associated with Epstein-Barr virus co-infection that most often occurs in the context of human immunodeficiency virus infection.
Camille Laurent, Bettina Fabiani, Catherine Do, Emmanuelle Tchernonog, Guillaume Cartron, Pauline Gravelle, Nadia Amara, Sandrine Malot, Maryknoll Mawanay Palisoc, Christiane Copie-Bergman, Alexandra Traverse Glehen, Marie-Christine Copin, Pierre Brousset, Stefania Pittaluga, Elaine S. Jaffe, Paul Coppo   +15 more
doaj   +1 more source

Novel Therapeutics for Epstein–Barr Virus [PDF]

Molecules, 2019
Epstein–Barr virus (EBV) is a human γ-herpesvirus that infects up to 95% of the adult population. Primary EBV infection usually occurs during childhood and is generally asymptomatic, though the virus can cause infectious mononucleosis in 35–50% of the cases when infection occurs later in life.
Andrei, Graciela, Trompet, Erika, Snoeck, Robert   +2 more
openaire   +3 more sources

Epstein-Barr virus latent proteins regulate expression of the anti-apoptotic cellular bfl-1 gene [PDF]

, 2005
The ubiquitous and oncogenic human herpes-virus Epstem-Barr virus (EB V) establishes a latent infection and promotes the long-term survival of the infected host cell by targeting the molecular machinery that controls cell fate decisions, including ...
Smith, Sinéad M.
core  

Genetic‐Proteomic Integration Identifies Predictive Plasma Proteins for Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Multiple sclerosis (MS) develops after a prolonged preclinical phase. Identifying circulating biomarkers that capture this early biology can improve risk stratification and guide intervention. We aimed to identify plasma proteins driving MS susceptibility using large‐scale proteogenomic integration and to evaluate their prediagnostic ...
Yuan Ding, Dylan Hamitouche, Simon Thebault, Patrick Kearns, Ahmed Abdelhak, Adil Harroud   +5 more
wiley   +1 more source

Monoallelic POLR3A Variants Cause Early‐Onset Peripheral Neuropathy

Annals of Neurology, EarlyView.
Objective Biallelic variants in genes encoding the RNA polymerase III complex (Pol III) cause a spectrum of neurological disorders primarily affecting the central nervous system. Monoallelic variants have been reported in the POLR3B subunit only, associated with neurodevelopmental disorder, epilepsy, and peripheral neuropathy.
Luiza L. P. Ramos, Jevin M. Parmar, Robin Wijngaard, Bianca R. Grosz, Tamas Lazar, Ligia Mateiu, Steve Vucic, Kishore R. Kumar, Dennis Yeow, Laura I. Rudaks, Lonneke de Boer, Annemarie de Vreugd, David A. Koolen, Thatjana Gardeitchik, Anita Cairns, Krishnan Iyengar, Fernando Kok, Fernanda Barbosa Figueiredo, Alzira Alves de Siqueira Carvalho, Luiz S. Mageste Barbosa, Rodrigo Rezende Arantes, Tyler Rehbein, Jordan E. Bontrager, Elizabeth P. Wood, Janet E. Sowden, Gavin Monahan, Meutia Kumaheri, Ivy Cuijt, Melina Ellis, Gonzalo Perez‐Siles, Elyshia McNamara, Ronald van Beek, Celine B. Meijers, Ivaylo Tournev, Stephan Zuchner, Shoshana J. Wodak, Clara D. M. van Karnebeek, Nigel Laing, Liana N. Semcesen, David A. Stroud, David N. Herrmann, Velina Guergueltcheva, Marina L. Kennerson, Machteld M. Oud, Gianina Ravenscroft, Ayse Candayan, Albena Jordanova   +46 more
wiley   +1 more source

Latent Epstein-Barr virus infection and the germinal center reaction [PDF]

, 2007
Epstein-Barr virus (EBV) is a γ-herpes virus which preferentially infects human B lymphocytes. It is highly adapted to persist in B cells since it encodes for proteins which mimic several cellular proteins playing an important role in B cell ...
Rastelli, Julia, Rastelli, J.
core  

From Marginal to Central: Marginal Zone‐like B Cells as Critical Targets in Cladribine‐Treated Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Multiple sclerosis (MS) is a chronic autoimmune disease where B cells play a central pathogenic role. Cladribine, an oral therapy, provides durable benefits by reshaping lymphocyte populations, yet its specific long‐term impact on distinct B‐cell subsets is not fully understood.
Marta Pirronello, Mario Picozza, Gisella Guerrera, Silvia Corbisiero, Andrea Misiti, Roberta C. Placido, Alice Verdiani, Lorenzo de Marco, Manolo Sambucci, Elena Olivieri, Daniela F. Angelini, Esmeralda Quartuccio, Luca Prosperini, Carla Tortorella, Maria C. Buscarinu, Valeria Zancan, Francesca de Masi, Marco Salvetti, Claudio Gasperini, Giovanna Borsellino, Luca Battistini   +20 more
wiley   +1 more source

Atypical manifestations of Epstein–Barr virus in children: a diagnostic challenge

Jornal de Pediatria, 2016
Objective: Clarify the frequency and the pathophysiological mechanisms of the rare manifestations of Epstein–Barr virus infection. Sources: Original research studies published in English between 1985 and 2015 were selected through a computer-assisted ...
Vasileios Bolis, Christos Karadedos, Ioannis Chiotis, Nikolaos Chaliasos, Sophia Tsabouri   +4 more
doaj   +1 more source

A global view of the oncogenic landscape in nasopharyngeal carcinoma : an integrated analysis at the genetic and expression levels [PDF]

, 2012
Previous studies have reported that the tumour cells of nasopharyngeal carcinoma (NPC) exhibit recurrent chromosome abnormalities. These genetic changes are broadly assumed to lead to changes in gene expression which are important for the pathogenesis of
Aicha Amari, Murray, Paul G, Dawson, Christopher W, Wei, Wenbin, Xiaoyi Chen (150873), Sim K. Sihota (150887), Shao, Jian-Yong, Andrew I Bell, Maloney, S.L., Nicholls, John M, Shao, J.Y., Aicha Amari (150894), Hu, C., K Dalia Derkaoui, Stephanie L Maloney, Wei, W., Arrand, J.R., Wenbin Wei (150871), Woodman, C.B., Sihota, Sim K, Murray, P.G., Ciaran B. Woodman (150878), Derkaoui, K.D., Ciaran B Woodman, Jian-Yong Shao (41845), Maloney, Stephanie L., Bell, Andrew I., Dawson, Christopher W., John M. Nicholls (150882), Derkaoui, K Dalia, Derkaoui, K. Dalia, Maloney, Stephanie L, Bell, A.I., Sihota, Sim K., Xiaoyi Chen, Lawrence S. Young (150912), Woodman, Ciaran B. J., Nicholls, J.M., Arrand, J. R. (John R.), Irène Joab (150885), Joab, Irène, Amari, Aicha, Arrand, John R, Woodman, Ciaran B, Wenbin Wei, Paul G. Murray (150907), Christopher W. Dawson (150910), Chen, X., Yao, Yunhong, Chunfang Hu, Dawson, C.W., Chunfang Hu (150868), K. Dalia Derkaoui (150892), Andrew I. Bell (150904), Chen, Xiaoyi, Young, Lawrence S., Joab, I., John R. Arrand (150915), Irène Joab, Christopher W Dawson, Nicholls, J. M. (John M.), Stephanie L. Maloney (150899), Yunhong Yao, Wei, Wenbin; id_orcid, Young, Lawrence S, Lawrence S Young, John R Arrand, John M Nicholls, Paul G Murray, Amari, A., Jian-Yong Shao, Bell, Andrew I; id_orcid, Yao, Y., Yunhong Yao (150880), Hu, Chunfang, Young, L.S., Sihota, S.K., Murray, Paul G., Sim K Sihota   +78 more
core   +1 more source

Proinflammatory Epstein–Barr Virus Antibody Functions Track with Disease Activity in Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Epstein–Barr virus (EBV) has been implicated in the pathogenesis of multiple sclerosis (MS). Elevated immunoglobulin G (IgG) titers against EBV nuclear antigen 1 (EBNA1) represent the most consistent serological marker of MS risk, with levels remaining persistently elevated following disease onset.
Malina Behrens, Paula Terroba‐Navajas, Eline A.J. Willemse, Sabine Schädelin, Manuel Comabella, Christian Münz, Gordan Lauc, Yannic Bartsch, Jens Kuhle, Jan D. Lünemann   +9 more
wiley   +1 more source