Results 101 to 110 of about 594,928 (357)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Evolution of foot-and-mouth disease virus

Virus Research, 2003
Foot-and-mouth disease virus evolution is strongly influenced by high mutation rates and a quasispecies dynamics. Mutant swarms are subjected to positive selection, negative selection and random drift of genomes. Adaptation is the result of selective amplification of subpopulations of genomes.
Domingo, Esteban, Escarmı́s, Cristina, Baranowski, Eric, Ruiz-Jarabo, Carmen, Carrillo, Elisa, Núñez, Juan Ignacio, Sobrino, Francisco   +6 more
openaire   +6 more sources

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Genetic diversity in the env V1-V2 region of proviral quasispecies from long-term controller MHC-typed cynomolgus macaques infected with SHIVSF162P4cy [PDF]

, 2018
Intra-host evolution of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) has been shown by viral RNA analysis in subjects who naturally suppress plasma viremia to low levels, known as controllers.
Borsetti, Alessandra, Capone, Alessia, Cella, Eleonora, Ciccozzi, Massimo, Ensoli, Barbara, Farcomeni, Stefania, Ferrantelli, Flavia, Lo Presti, Alessandra, Maggiorella, Maria T, Mee, Edward T, Rose, Nicola J, Sernicola, Leonardo   +11 more
core   +1 more source

New Perspectives on Ebola Virus Evolution

PLOS ONE, 2016
(Uploaded by Plazi for the Bat Literature Project) Since the recent devastating outbreak of Ebola virus disease in western Africa, there has been significant effort to understand the evolution of the deadly virus that caused the outbreak. There has been a considerable investment in sequencing Ebola virus (EBOV) isolates, and the results paint an ...
Celeste J. Brown, Christopher A. Mirabzadeh, F. Marty Ytreberg, Tanya A. Miura, Holly A. Wichman, Caleb J. Quates, Craig R. Miller   +6 more
openaire   +5 more sources

Zika virus evolution and spread in the Americas [PDF]

Nature, 2017
Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention, much remains unknown about ZIKV disease epidemiology and ZIKV evolution, in part owing to a lack of genomic data.
Mary Lynn Baniecki, Catherine M. Brown, Bridget Chak, Bridget Chak, Irene Bosch, Amanda L Tan, Nathan L. Yozwiak, Nathan L. Yozwiak, Sharon Isern, Maria Conseulo Miranda Montoya, Shirlee Wohl, Shirlee Wohl, Kimberly García, Salim Mattar, Giselle Barbosa-Lima, Patrícia T. Bozza, Mario C. Porcelli, Thiago Moreno L. Souza, M. Elizabeth Halloran, M. Elizabeth Halloran, José Cerbino-Neto, Lee Gehrke, Lee Gehrke, Brandon Sabina, Kayla G. Barnes, Kayla G. Barnes, Cynthia Y. Luo, Cynthia Y. Luo, Luis Angel Villar, Christian B. Matranga, Karthik Gangavarapu, Ivette Lorenzana, Scott Hennigan, Scott F. Michael, Rickey R. Shah, Rickey R. Shah, Refugio Robles-Sikisaka, Nathan D. Grubaugh, Adrianne Gladden-Young, Lauren M. Paul, Sarah Scotland, Andrew Rambaut, Andrew Rambaut, Aaron E. Lin, Aaron E. Lin, Kendra West, Bronwyn MacInnis, Bronwyn MacInnis, Kristian G. Andersen, Kristian G. Andersen, Daniel J. Park, Clarissa Valim, Clarissa Valim, Pardis C. Sabeti, Marshall R. Cone, James Qu, Yasmine Rangel Vieira, Fernando A. Bozza, Sarah M. Winnicki, Chalmers Vasquez, Stephen F. Schaffner, Stephen F. Schaffner, Sandra Smole, Kelly N. Hogan, Simon Ye, Simon Ye, Diana Patricia Rojas, Catherine A. Freije, Catherine A. Freije, Carolyn M. Barcellona, Andreas Gnirke, Glenn Oliveira, Andrew C. Cannons, Christopher Tomkins-Tinch, Joshua J. Anzinger, Rosa Margarita Gelvez Ramirez, Wim Degrave, Edgar W. Kopp, Edson Delatorre, Leda Parham, Hayden C. Metsky, Hayden C. Metsky   +81 more
openaire   +5 more sources

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

FEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman, Annika Egeler, Saskia Rödl, Johannes M. Herrmann   +3 more
wiley   +1 more source

Phylogeography of Japanese encephalitis virus:genotype is associated with climate [PDF]

, 2013
The circulation of vector-borne zoonotic viruses is largely determined by the overlap in the geographical distributions of virus-competent vectors and reservoir hosts.
A Igarashi, A Oya, A Rambaut, A Rambaut, AB Sabin, AJ Auguste, AJ Drummond, AJ Drummond, AJ Schuh, AJ Schuh, AJ Schuh, Alan D. T. Barrett, Amy C. Morrison, Amy J. Schuh, Andrew J. Leigh Brown, B Shapiro, BJ Smith, D Martin, D Posada, DP Martin, DP Martin, EK Cruickshank, EL Buescher, EL Buescher, EL Buescher, EL Buescher, EL Buescher, FA Rey, FJ May, G Baele, GL Campbell, GM Jenkins, H Tsuchie, H Weissenbock, HS Hurlbut, HY Wang, J Fox, J Parker, JE Bryant, JH Nam, JL Wang, JM Smith, JN Hanna, L Lewis, L Rosen, L Rosen, L Rosen, M Gouy, M Padidam, MA Mohammed, MA Suchard, Melissa J. Ward, MH Li, N Nitatpattana, P Lemey, PD Uchil, PT Nga, PV Fulmali, R Takhampunya, RS Lanciotti, S Guindon, S Kumar, SE Sulkin, SE Sulkin, SL Kosakovsky Pond, SL Kosakovsky Pond, SL Pond, SL Pond, SP Ma, T Bakonyi, T Mitamura, T Solomon, TJ Chambers, WF Scherer, WF Scherer, WF Scherer, WM Hammon, WR Chen, WR Chen, WS Paul, XL Pan, Y Kobayashi, YX Li, YY Chen   +83 more
core   +3 more sources

Evolution of Mutational Robustness in an RNA Virus

PLoS Biology, 2005
Mutational (genetic) robustness is phenotypic constancy in the face of mutational changes to the genome. Robustness is critical to the understanding of evolution because phenotypically expressed genetic variation is the fuel of natural selection. Nonetheless, the evidence for adaptive evolution of mutational robustness in biological populations is ...
Montville, Rebecca, Froissart, Remy, Remold, Susanna, Tenaillon, Olivier, Turner, Paul   +4 more
openaire   +6 more sources

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source