Results 1 to 10 of about 105,888 (295)

Nisoldipine Inhibits Influenza A Virus Infection by Interfering with Virus Internalization Process [PDF]

Viruses, 2022
Influenza virus infections and the continuing spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are global public health concerns. As there are limited therapeutic options available in clinical practice, the rapid development of safe,
Yingna Huang, Yinyan Li, Zhixuan Chen, Liurong Chen, Jinlong Liang, Chunyu Zhang, Zhengyin Zhang, Jie Yang   +7 more
doaj   +4 more sources

Ritonavir Blocks Hepatitis E Virus Internalization and Clears Hepatitis E Virus In Vitro with Ribavirin [PDF]

Viruses, 2022
Hepatitis E virus (HEV) is increasingly recognized as the leading cause of acute hepatitis. Although HEV infections are mostly self-limiting, a chronic course can develop especially in those with immunocompromised state.
Putu Prathiwi Primadharsini, Shigeo Nagashima, Masaharu Takahashi, Kazumoto Murata, Hiroaki Okamoto   +4 more
doaj   +2 more sources

Human Platelets and Influenza Virus: Internalization and Platelet Activation [PDF]

Platelets, 2022
Influenza infection has long been associated with prothrombotic outcomes in patients and platelets are the blood component predominantly responsible for thrombosis. In this review, we outline what is known about influenza interaction with human platelets,
Josiah Bote, Heather A. Corkrey, Milka Koupenova   +2 more
doaj   +2 more sources

Direct Interaction Between CD163 N-Terminal Domain and MYH9 C-Terminal Domain Contributes to Porcine Reproductive and Respiratory Syndrome Virus Internalization by Permissive Cells [PDF]

Frontiers in Microbiology, 2019
Porcine reproductive and respiratory syndrome virus (PRRSV) has a highly restricted tropism for cells of the monocyte-macrophage lineage, including porcine alveolar macrophages (PAMs).
Gaopeng Hou, Biyun Xue, Liangliang Li, Yuchen Nan, Lu Zhang, Kuokuo Li, Qin Zhao, Julian A. Hiscox, James P. Stewart, Chunyan Wu, Jingfei Wang, En-Min Zhou   +11 more
doaj   +2 more sources

Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells [PDF]

Veterinary Research, 2018
Canine respiratory coronavirus (CRCoV), identified in 2003, is a member of the Coronaviridae family. The virus is a betacoronavirus and a close relative of human coronavirus OC43 and bovine coronavirus.
Artur Szczepanski, Katarzyna Owczarek, Aleksandra Milewska, Zbigniew Baster, Zenon Rajfur, Judy A. Mitchell, Krzysztof Pyrc   +6 more
doaj   +10 more sources

Internalization-related host factors of common respiratory viruses [PDF]

Frontiers in Immunology
Respiratory viruses impose a substantial health burden worldwide, with viral internalization into host cells being the initial step for infection establishment.
Qiuchi Lv, Qiuchi Lv, Qiuchi Lv, Qiuchi Lv, Zhengde Xie, Zhengde Xie, Zhengde Xie, Zhengde Xie, Lili Xu, Lili Xu, Lili Xu, Lili Xu   +11 more
doaj   +2 more sources

Cell surface α2,3-linked sialic acid facilitates Zika virus internalization [PDF]

Emerging Microbes and Infections, 2019
The emergence of neurotropic Zika virus (ZIKV) raised a public health emergency of global concern. ZIKV can cross the placental barrier and infect foetal brains, resulting in microcephaly, but the pathogenesis of ZIKV is poorly understood.
Chee Wah Tan, Catherine Hong Huan Hor, Swee Sen Kwek, Han Kang Tee, I-Ching Sam, Eyleen L. K. Goh, Eng Eong Ooi, Yoke Fun Chan, Lin-Fa Wang   +8 more
doaj   +2 more sources

αVβ3 Integrin Expression Is Essential for Replication of Mosquito and Tick-Borne Flaviviruses in Murine Fibroblast Cells

Viruses, 2021
The Flavivirus genus includes a number of important viruses that are pathogenic to humans and animals and are responsible for outbreaks across the globe.
Vinicius Pinho dos Reis, Markus Keller, Katja Schmidt, Rainer Günter Ulrich, Martin Hermann Groschup   +4 more
doaj   +1 more source

A genome-wide CRISPR/Cas9 gene knockout screen identifies immunoglobulin superfamily DCC subclass member 4 as a key host factor that promotes influenza virus endocytosis.

PLoS Pathogens, 2021
Influenza virus infection is dependent on host cellular factors, and identification of these factors and their underlying mechanisms can provide important information for the development of strategies to inhibit viral infection.
Yangming Song, Haixiang Huang, Yuzhen Hu, Jiwen Zhang, Fang Li, Xin Yin, Jianzhong Shi, Yanbing Li, Chengjun Li, Dongming Zhao, Hualan Chen   +10 more
doaj   +1 more source

Characterization of Zika virus endocytic pathways in human glioblastoma cells [PDF]

, 2020
Zika virus (ZIKV) infections can cause microcephaly and neurological disorders. However, the early infection events of ZIKV in neural cells remain to be characterized. Here, by using a combination of pharmacological and molecular approaches and the human
Du, T, Fu, M, Griffin, GE, Hu, Q, Li, C, Li, M, Liu, Y, Ni, F, Wang, H, Zhang, D, Zhang, M, Zheng, Z   +11 more
core   +1 more source