Results 91 to 100 of about 105,888 (295)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

African swine fever virus uses macropinocytosis to enter host cells. [PDF]

PLoS Pathogens, 2012
African swine fever (ASF) is caused by a large and highly pathogenic DNA virus, African swine fever virus (ASFV), which provokes severe economic losses and expansion threats.
Elena G Sánchez, Ana Quintas, Daniel Pérez-Núñez, Marisa Nogal, Susana Barroso, Ángel L Carrascosa, Yolanda Revilla   +6 more
doaj   +1 more source

Endocytosis of the ASGP receptor H1 is reduced by mutation of tyrosine-5 but still occurs via coated pits [PDF]

, 1991
The clustering of plasma membrane receptors in clathrin-coated pits depends on determinants within their cytoplasmic domains. In several cases, individual tyrosine residues were shown to be necessary for rapid internalization.
Fuhrer, C., Geffen, I., Spiess, M.
core   +3 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Protective essential oil attenuates influenza virus infection: An in vitro study in MDCK cells

BMC Complementary and Alternative Medicine, 2010
Background Influenza is a significant cause of morbidity and mortality. The recent pandemic of a novel H1N1 influenza virus has stressed the importance of the search for effective treatments for this disease. Essential oils from aromatic plants have been
Metcalf Jordan P, Booth Leland J, Patel Krupa B, Wu Shuhua, Lin Hsueh-Kung, Wu Wenxin   +5 more
doaj   +1 more source

Internal ribosome entry site within hepatitis C virus RNA [PDF]

Journal of Virology, 1992
The mechanism of initiation of translation on hepatitis C virus (HCV) RNA was investigated in vitro. HCV RNA was transcribed from the cDNA that corresponded to nucleotide positions 9 to 1772 of the genome by using phage T7 RNA polymerase. Both capped and uncapped RNAs thus transcribed were active as mRNAs in a cell-free protein synthesis system with ...
K, Tsukiyama-Kohara, N, Iizuka, M, Kohara, A, Nomoto   +3 more
openaire   +2 more sources

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Population balances in case of crossing characteristic curves: Application to T-cells immune response [PDF]

, 2016
The progression of a cell population where each individual is characterized by the value of an internal variable varying with time (e.g. size, weight, and protein concentration) is typically modeled by a Population Balance Equation, a first order linear ...
Abbott, Bidot, Bidot, Cameron, Coombs, El-Hentati, Elimelech, Grakoui, Haseltine, Hjortso, Hodge, Hong, Ingram, Kavousanakis, Keith, Khalili, Lax, LeVeque, Lifshitz, Majumder, Marchisio, Muhr, Qamar, Qamar, Qamar, Qamar, Ramkrishna, Ramkrishna, Ramkrishna, Randolph, Roussos, Shu, Sidorenko, Sidorenko, Sousa, Stamatakis, Valitutti, Vetter   +37 more
core   +4 more sources

8th International Conference on Oncolytic Virus Therapeutics

Human Gene Therapy, 2014
The 8th International Conference on Oncolytic Virus Therapeutics meeting was held from April 10–13, 2014, in Oxford, United Kingdom. It brought together experts in the field of oncolytics from Europe, Asia, Australasia, and the Americas and provided a unique opportunity to hear the latest research findings in oncolytic virotherapy.
Guinn, Barbara-Ann, Braidwood, Lynne, Parker, Alan, Peng, Kah-Whye, Seymour, Leonard   +4 more
openaire   +2 more sources

Encephalomyocarditis virus internal ribosomal entry site RNA-protein interactions [PDF]

Journal of Virology, 1994
Translational initiation of encephalomyocarditis virus (EMCV) mRNA occurs by ribosomal entry into the 5' nontranslated region of the EMCV mRNA, rather than by ribosomal scanning. Internal ribosomal binding requires a cis-acting element termed the internal ribosomal entry site (IRES). IRES elements have been proposed to be involved in the translation of
G W, Witherell, E, Wimmer
openaire   +2 more sources