Results 111 to 120 of about 61,434 (287)

Temporal dynamics of protein complex formation and dissociation during human cytomegalovirus infection

Nature Communications, 2020
Here, Hashimoto et al. apply mass spectrometry-based thermal proximity coaggregation to characterize the temporal dynamics of virus-host protein-protein interactions during human cytomegalovirus (HCMV) infection, uncovering proviral functions including ...
Yutaka Hashimoto, Xinlei Sheng, Laura A. Murray-Nerger, Ileana M. Cristea   +3 more
doaj   +1 more source

The TGEV Membrane Protein Interacts with HSC70 To Direct Virus Internalization through Clathrin-Mediated Endocytosis. [PDF]

J Virol, 2023
Ji Z, Dong H, Jiao R, Zhu X, Shi H, Chen J, Shi D, Liu J, Jing Z, Zhang J, Wang X, Ye D, Zhang J, Zhang X, Feng L.   +14 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Neutralizing antibodies to different proteins of African swine fever virus inhibit both virus attachment and internalization

, 1996
African swine fever virus induces in convalescent pigs antibodies that neutralized the virus before and after binding to susceptible cells, inhibiting both virus attachment and internalization. A further analysis of the neutralization mechanisms mediated
Oviedo, J. M., Alonso Martí, Covadonga, Escribano, J. M., Gómez-Puertas, Paulino, Ruiz-Gonzalvo, F., Ramiro-Ibáñez, F., Rodríguez, Fernando   +6 more
core  

Glycoprotein D actively induces rapid internalization of two nectin-1 isoforms during herpes simplex virus entry

, 2010
Entry of herpes simplex virus (HSV) occurs either by fusion at the plasma membrane or by endocytosis and fusion with an endosome. Binding of glycoprotein D (gD) to a receptor such as nectin-1 is essential in both cases.
Krummenacher, Claude, Stiles, Katie M.
core   +1 more source

CD44 mediates the internalization of foot-and-mouth disease virus through macropinocytosis

Veterinary Research
Foot-and-mouth disease virus (FMDV), a member of the Picornavirus family, poses a significant threat to global animal husbandry. While it is known that macropinocytosis plays a crucial role in the entry of FMDV into cells, the specific cellular proteins ...
Xuefei Wang, Hu Dong, Jin’en Wu, Yun Zhang, Shiqi Sun, Huichen Guo   +5 more
doaj   +1 more source

A Diacylglycerol Kinase Inhibitor, R-59-022, Blocks Filovirus Internalization in Host Cells

Viruses, 2019
Filoviruses, such as Ebola virus (EBOV) and Marburg virus, are causative agents of unpredictable outbreaks of severe hemorrhagic fevers in humans and non-human primates.
Corina M. Stewart, Stephanie S. Dorion, Marie A. F. Ottenbrite, Nicholas D. LeBlond, Tyler K. T. Smith, Shirley Qiu, Morgan D. Fullerton, Darwyn Kobasa, Marceline Côté   +8 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Dendritic cell internalization of foot-and-mouth disease virus Influence of heparan sulfate binding on virus uptake and induction of the immune response

, 2008
Dendritic cells (DC), which are essential for inducing and regulating immune defenses and responses, represent the critical target for vaccines against pathogens such as foot-and-mouth disease virus (FMDV).
Harwood, L. J., Sobrino Castelló, Francisco, McCullough, Kenneth C., Gerber, H., Summerfield, A.   +4 more
core   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source