Results 11 to 20 of about 778,919 (247)

Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins

Cell, 2022
Summary Methods to deliver gene editing agents in vivo as ribonucleoproteins could offer safety advantages over nucleic acid delivery approaches.
Samagya Banskota, Aditya Raguram, Susie Suh, Samuel W. Du, Jessie R. Davis, Elliot H. Choi, Xiao Wang, Sarah C. Nielsen, Gregory A. Newby, Peyton B. Randolph, Mark J. Osborn, K. Musunuru, K. Palczewski, David R. Liu   +13 more
semanticscholar   +3 more sources

Restriction of HIV-1 replication in monocytes is abolished by Vpx of SIVsmmPBj [PDF]

, 2009
Background: Human primary monocytes are refractory to infection with the human immunodeficiency virus 1 (HIV-1) or transduction with HIV-1-derived vectors.
Silke Schüle, Björn-Philipp Kloke, Julia K. Kaiser, Sabine Heidmeier, Sylvia Panitz, Nina Wolfrum, Klaus Cichutek, Matthias Schweizer, Reuben S. Harris, S Neil, S Sonza, MD Mühlebach, S Sonza, K Triques, G Peng, V Arfi, YL Chiu, PJ Ellery, M Pion, N Wolfrum, TM Fletcher 3rd, C Goujon, C Goujon, R Sleigh, S Mahalingam, LA Mahnke, HA Pancio, H Schuitemaker, T Kino, P Di Marzio, L Selig, L Jarrosson-Wuilleme, JA Poole, VM Hirsch, JA LaBonte, K Lee, B Song, M Stremlau, R Mariani, G Brennan, A Gruber, PH Tan, M Belshan, PK Singhal, C Goujon, N Sharova, C Dong, LY Liou, G Peng, Y Iwatani, JC Kappes, G Berger, R Sakuma, R Sakuma, M Stremlau, J Shi, E Sokolskaja, PK Singhal, R Sakuma, L Naldini, PM Strappe, DS Ory   +61 more
core   +12 more sources

Platforms, advances, and technical challenges in virus-like particles-based vaccines

Frontiers in Immunology, 2023
Viral infectious diseases threaten human health and global stability. Several vaccine platforms, such as DNA, mRNA, recombinant viral vectors, and virus-like particle-based vaccines have been developed to counter these viral infectious diseases.
Reeshu Gupta, K. Arora, Sourav Roy, A. Joseph, Ruchir Rastogi, N. M. Arora, P. Kundu   +6 more
semanticscholar   +1 more source

Virus-Like Particles: Revolutionary Platforms for Developing Vaccines Against Emerging Infectious Diseases

Frontiers in Microbiology, 2022
Virus-like particles (VLPs) are nanostructures that possess diverse applications in therapeutics, immunization, and diagnostics. With the recent advancements in biomedical engineering technologies, commercially available VLP-based vaccines are being ...
Hasnat Tariq, Sannia Batool, Saaim Asif, Mohammad Ali, B. Abbasi   +4 more
semanticscholar   +1 more source

Rapid assessment of SARS-CoV-2–evolved variants using virus-like particles

bioRxiv, 2021
Newly evolved SARS-CoV-2 variants are driving ongoing outbreaks of COVID-19 around the world. Efforts to determine why these viral variants have improved fitness are limited to mutations in the viral spike (S) protein and viral entry steps using non-SARS-
A. Syed, T. Y. Taha, M. Khalid, T. Tabata, I. Chen, B. Sreekumar, Pei-Yi Chen, J. Hayashi, K. Soczek, M. Ott, J. Doudna   +10 more
semanticscholar   +1 more source

Virus-like Particles: Fundamentals and Biomedical Applications

International Journal of Molecular Sciences, 2022
Nanotechnology is a fast-evolving field focused on fabricating nanoscale objects for industrial, cosmetic, and therapeutic applications. Virus-like particles (VLPs) are self-assembled nanoparticles whose intrinsic properties, such as heterogeneity, and ...
Jorge L. Mejía-Méndez, R. Vázquez-Duhalt, L. R. Hernández, Eugenio Sánchez-Arreola, H. Bach   +4 more
semanticscholar   +1 more source

Virus-like Particles as Nanocarriers for Intracellular Delivery of Biomolecules and Compounds

Viruses, 2022
Virus-like particles (VLPs) are nanostructures assemble from viral proteins. Besides widely used for vaccine development, VLPs have also been explored as nanocarriers for cargo delivery as they combine the key advantages of viral and non-viral vectors ...
Junyao He, Linying Yu, Xiaodi Lin, Xiaoya Liu, Yanming Zhang, Fan Yang, Wen Deng   +6 more
semanticscholar   +1 more source

Virus-like Particles as Preventive and Therapeutic Cancer Vaccines

Vaccines, 2022
Virus-like particles (VLPs) are self-assembled viral protein complexes that mimic the native virus structure without being infectious. VLPs, similarly to wild type viruses, are able to efficiently target and activate dendritic cells (DCs) triggering the ...
A. Tornesello, M. Tagliamonte, F. Buonaguro, M. Tornesello, L. Buonaguro   +4 more
semanticscholar   +1 more source

Size-selective downstream processing of virus particles and non-enveloped virus-like particles

Frontiers in Bioengineering and Biotechnology, 2023
Non-enveloped virus-like particles (VLPs) are versatile protein nanoparticles with great potential for biopharmaceutical applications. However, conventional protein downstream processing (DSP) and platform processes are often not easily applicable due to
Nils Hillebrandt, Jürgen Hubbuch
doaj   +1 more source

Zika virus like particles elicit protective antibodies in mice. [PDF]

PLoS Neglected Tropical Diseases, 2018
Mosquito-borne Zika virus (ZIKV) typically causes a mild and self-limiting illness known as Zika fever. Since its recent emergence in 2014 in the American continent, ZIKV infection during pregnancy has been closely associated with a wide range of ...
Mauricio A Salvo, Brock Kingstad-Bakke, Cristhian Salas-Quinchucua, Erwin Camacho, Jorge E Osorio   +4 more
doaj   +1 more source