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Size-selective downstream processing of virus particles and non-enveloped virus-like particles
Frontiers in Bioengineering and Biotechnology, 2023 Non-enveloped virus-like particles (VLPs) are versatile protein nanoparticles with great potential for biopharmaceutical applications. However, conventional protein downstream processing (DSP) and platform processes are often not easily applicable due to
Nils Hillebrandt, Jürgen Hubbuch
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Platelet-like particles released from Ebola virus-infected megakaryocytic cells behave like virus-like particles. [PDF]
PLoS PathogensEbola virus (EBOV) is likely a zoonotic and re-emerging virus that causes severe outbreaks of Ebola virus disease. The virus spreads to various tissues during the late stage of infection and has been detected in immune-privileged sites of survivors ...
Makoto Kuroda, Peter J Halfmann
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Recent Progress on the Versatility of Virus-Like Particles
Vaccines, 2020 Virus-like particles (VLPs) are multimeric nanostructures composed of one or more structural proteins of a virus in the absence of genetic material. Having similar morphology to natural viruses but lacking any pathogenicity or infectivity, VLPs have ...
Ciying Qian +10 more
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Virus-Like Particles as an Immunogenic Platform for Cancer Vaccines
Viruses, 2020 Virus-like particles (VLP) spontaneously assemble from viral structural proteins. They are naturally biocompatible and non-infectious. VLP can serve as a platform for many potential vaccine epitopes, display them in a dense repeating array, and elicit ...
Jerri C. Caldeira +3 more
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Immunogenicity of Virus-like Particles Based on VP1 Protein of Bovine Norovirus [PDF]
Veterinary SciencesBovine Norovirus (BNoV) is a member of the enterovirus family that can cause gastroenteritis in calves. This virus poses a significant risk to calf growth and development as well as to the long-term sustainability of the cattle industry in China and ...
Zhigang Ma +13 more
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Virus-like Particles: Measures and Biological Functions
Viruses, 2022 Virus-like particles resemble infectious virus particles in size, shape, and molecular composition; however, they fail to productively infect host cells.
Tara Bhat, Amy Cao, John Yin
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Characterization of chikungunya virus-like particles. [PDF]
PLoS ONE, 2014 Chikungunya virus (CHIKV) is becoming a global concern due to the increasing number of outbreaks throughout the world and the absence of any CHIKV-specific vaccine or treatment.
Nitchakarn Noranate +5 more
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Zika virus like particles elicit protective antibodies in mice. [PDF]
PLoS Neglected Tropical Diseases, 2018 Mosquito-borne Zika virus (ZIKV) typically causes a mild and self-limiting illness known as Zika fever. Since its recent emergence in 2014 in the American continent, ZIKV infection during pregnancy has been closely associated with a wide range of ...
Mauricio A Salvo +4 more
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Production of mosquito cell-derived Zika virus-like particles using BacMos system
Journal of Medical Sciences, 2021 Background: Zika virus (ZIKV) is a mosquito-borne flavivirus which has been conclusively linked to Guillain-Barré syndrome and microcephaly. The worldwide emergence of ZIKV has greatly increased the demand for vaccines that reduce or prevent disease ...
Hui-Tsu Lin +2 more
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Preparation of Class Y Immunoglobulins that Neutralize the Marburg Virus
Проблемы особо опасных инфекций, 2021 The aim was to study the possibility of inducing Marburg-neutralizing chicken antibodies (MARV) using various immunogens.Materials and methods. Recombinant vaccinia virus expressing the surface glycoprotein (GP) transgene MARV of Musoke strain and ...
O. A. Polezhaeva +7 more
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