Results 31 to 40 of about 214,356 (305)

Ultrastructural aspects of virus replication in one fatal case and several other isolates from a dengue type 2 outbreak in Rio de Janeiro

Memorias do Instituto Oswaldo Cruz, 1994
Dengue virus replication in mosquito cell cultures was observed by electron microscopy in one fatal and 40 classical isolates from a dengue type 2 outbreak in Rio de Janeiro and compared with the prototype New Guinea C strain.
Ortrud Monika Barth, Luzia Monteiro de Castro Côrtes, Elisabeth Lampe, José da Costa Farias Filho   +3 more
doaj   +1 more source

The gag-like gene RTL8 antagonizes PEG10-mediated virus like particles

PLoS ONE
PEG10 is a retroelement-derived Mart-family gene that is necessary for placentation and has been implicated in neurological disease. PEG10 resembles both retrotransposon and retroviral proteins and forms virus-like particles (VLPs) that can be purified ...
Will Campodonico, Harihar M. Mohan, Phuoc T. Huynh, Holly H. Black, Cristina I. Lau, Henry L. Paulson, Lisa M. Sharkey, Alexandra M. Whiteley   +7 more
doaj   +2 more sources

The effects of high shear rates on the average hydrodynamic diameter measured in biomimetic HIV Gag virus-like particle dispersions

Frontiers in Bioengineering and Biotechnology
HIV Gag virus-like particles (HIV Gag VLPs) are promising HIV vaccine candidates. In the literature, they are often described as shear-sensitive particles, and authors usually recommend the operation of tangential flow filtration (TFF) gently at shear ...
Tobias Wolf, Tobias Wolf, Kerim Kadir Calisan, Jörn Stitz, Stéphan Barbe   +4 more
doaj   +1 more source

Evaluation of the Thermal Stability of a Vaccine Prototype Based on Virus-like Particle Formulated HIV-1 Envelope

Vaccines, 2022
The long-term storage stability of vaccines has a major impact on the roll-out and success of global immunization programs. For the Human Immunodeficiency Virus type 1 (HIV-1) virus-like particle (VLP) vaccine prototype evaluated here, nanoparticle ...
Diana Aguado-Garcia, Alex Olvera, Christian Brander, Victor Sanchez-Merino, Eloisa Yuste   +4 more
doaj   +1 more source

Preclinical Evaluation of Novel Sterically Optimized VLP-Based Vaccines against All Four DENV Serotypes

Vaccines
Over the past few decades, dengue fever has emerged as a significant global health threat, affecting tropical and moderate climate regions. Current vaccines have practical limitations, there is a strong need for safer, more effective options.
Dominik A. Rothen, Sudip Kumar Dutta, Pascal S. Krenger, Anne-Cathrine S. Vogt, Ilva Lieknina, Jan M. Sobczak, Albert D. M. E. Osterhaus, Mona O. Mohsen, Monique Vogel, Byron Martina, Kaspars Tars, Martin F. Bachmann   +11 more
doaj   +1 more source

The structural basis for the integrity of adenovirus Ad3 dodecahedron [PDF]

, 2012
During the viral life cycle adenoviruses produce excess capsid proteins. Human adenovirus serotype 3 (Ad3) synthesizes predominantly an excess of free pentons, the complexes of pentameric penton base and trimeric fiber proteins, which are responsible for
Fender, Pascal, Monika Zochowska (134637), Jean-Pierre Andrieu, Ewa Szolajska (134629), Stephen Cusack (134664), Burmeister, Wim P, Pascal Fender (132764), Szolajska, Ewa, Pascal Fender, Nerlo, Barbara, Burmeister, Wim P., Igor Andreev, Wim P. Burmeister (134634), Wim P Burmeister, Guy Schoehn, Jadwiga Chroboczek (134668), Andreev, Igor, Naskalska, Antonina, Stephen Cusack, Chroboczek, Jadwiga, Barbara Nerlo (134643), Ewa Szolajska, Chloe Zubieta (134662), Barbara Nerlo, Igor Andreev (134649), Andrieu, Jean-Pierre, Jadwiga Chroboczek, Chloe Zubieta, Monika Zochowska, Zochowska, Monika, Cusack, Stephen, Jean-Pierre Andrieu (134655), Schoehn, Guy, Antonina Naskalska, Guy Schoehn (27525), Zubieta, Chloe, Antonina Naskalska (134660)   +36 more
core   +1 more source

Protein Cargo Encapsulation by Virus-Like Particles: Strategies and Applications

, 2022
Viruses and the recombinant protein cages assembled from their structural proteins, known as virus-like particles (VLPs), have gained wide interest as tools in biotechnology and nanotechnology.
Noor, Dashti, Frank, Sainsbury, Li Chen, Cheah, Donna, McNeale   +3 more
core   +1 more source

Superior Potency of Synthetic Virus-like Structures in Vaccine-Induced Antibody Responses Compared to Qβ Bacteriophage Virus-like Particles

Viruses
Virus-like particles are a well-established platform for vaccines, although the molecular mechanisms that underlie the extraordinary potency of many virus-like particles in eliciting strong antibody responses remain incompletely understood. Here, we show
Alexander R. Meyer, Libo Li, Wei-Yun Wholey, Bryce Chackerian, Wei Cheng   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Construction and Immunogenicity Comparison of Three Virus-Like Particles Carrying Different Combinations of Structural Proteins of Avian Coronavirus Infectious Bronchitis Virus

Vaccines, 2021
Infectious bronchitis virus (IBV) poses massive economic losses in the global poultry industry. Here, we firstly report the construction and immunogenicity comparison of virus-like particles (VLPs) carrying the S, M and E proteins (SME-VLPs); VLPs ...
Yu Zhang, Yuan Yuan, Li-Hua Zhang, Dan Zhu, Lu Wang, Lan-Ping Wei, Wen-Sheng Fan, Chang-Run Zhao, Yan-Jing Su, Jian-Qi Liao, Lu Yong, Tian-Chao Wei, Ping Wei, Mei-Lan Mo   +13 more
doaj   +1 more source