Results 31 to 40 of about 368,709 (304)

N,N'-dimethylnitrosourea-induced tumors in mice and Syrian hamsters [PDF]

, 1974
Carcinogenic effect of N, N'-dimethylnitrosourea (DMNU) on mice and hamsters was studied. Repeated subcutaneous injections　of DMNU resulted in the induction of malignant lymphomas with an　incidence of 100 per cent in adult C3HjBifBjKi mice ...
Hiraki, Shunkichi
core   +1 more source

Ultrastructural aspects of virus replication in one fatal case and several other isolates from a dengue type 2 outbreak in Rio de Janeiro

Memorias do Instituto Oswaldo Cruz, 1994
Dengue virus replication in mosquito cell cultures was observed by electron microscopy in one fatal and 40 classical isolates from a dengue type 2 outbreak in Rio de Janeiro and compared with the prototype New Guinea C strain.
Ortrud Monika Barth, Luzia Monteiro de Castro Côrtes, Elisabeth Lampe, José da Costa Farias Filho   +3 more
doaj   +1 more source

The gag-like gene RTL8 antagonizes PEG10-mediated virus like particles

PLoS ONE
PEG10 is a retroelement-derived Mart-family gene that is necessary for placentation and has been implicated in neurological disease. PEG10 resembles both retrotransposon and retroviral proteins and forms virus-like particles (VLPs) that can be purified ...
Will Campodonico, Harihar M. Mohan, Phuoc T. Huynh, Holly H. Black, Cristina I. Lau, Henry L. Paulson, Lisa M. Sharkey, Alexandra M. Whiteley   +7 more
doaj   +2 more sources

A virus biosensor with single virus-particle sensitivity based on fluorescent vesicle labels and equilibrium fluctuation analysis [PDF]

, 2013
Biosensors allowing for the rapid and sensitive detection of viral pathogens in environmental or clinical samples are urgently needed to prevent disease outbreaks and spreading.
Bally, Marta, Graule, Mauritz, Höök, Fredrik, Larson, Göran, Parra, F.   +4 more
core   +1 more source

The effects of high shear rates on the average hydrodynamic diameter measured in biomimetic HIV Gag virus-like particle dispersions

Frontiers in Bioengineering and Biotechnology
HIV Gag virus-like particles (HIV Gag VLPs) are promising HIV vaccine candidates. In the literature, they are often described as shear-sensitive particles, and authors usually recommend the operation of tangential flow filtration (TFF) gently at shear ...
Tobias Wolf, Tobias Wolf, Kerim Kadir Calisan, Jörn Stitz, Stéphan Barbe   +4 more
doaj   +1 more source

Preclinical Evaluation of Novel Sterically Optimized VLP-Based Vaccines against All Four DENV Serotypes

Vaccines
Over the past few decades, dengue fever has emerged as a significant global health threat, affecting tropical and moderate climate regions. Current vaccines have practical limitations, there is a strong need for safer, more effective options.
Dominik A. Rothen, Sudip Kumar Dutta, Pascal S. Krenger, Anne-Cathrine S. Vogt, Ilva Lieknina, Jan M. Sobczak, Albert D. M. E. Osterhaus, Mona O. Mohsen, Monique Vogel, Byron Martina, Kaspars Tars, Martin F. Bachmann   +11 more
doaj   +1 more source

Evaluation of the Thermal Stability of a Vaccine Prototype Based on Virus-like Particle Formulated HIV-1 Envelope

Vaccines, 2022
The long-term storage stability of vaccines has a major impact on the roll-out and success of global immunization programs. For the Human Immunodeficiency Virus type 1 (HIV-1) virus-like particle (VLP) vaccine prototype evaluated here, nanoparticle ...
Diana Aguado-Garcia, Alex Olvera, Christian Brander, Victor Sanchez-Merino, Eloisa Yuste   +4 more
doaj   +1 more source

Stability and assembly of bacteriophage PP7 virus-like particles [PDF]

, 2007
Background The stability of a virus-like particle (VLP) is an important consideration for its use in nanobiotechnology. The icosahedral capsid of the RNA bacteriophage PP7 is cross-linked by disulfide bonds between coat protein dimers at its 5-fold and ...
Jerri C Caldeira, David S Peabody
core   +2 more sources

Superior Potency of Synthetic Virus-like Structures in Vaccine-Induced Antibody Responses Compared to Qβ Bacteriophage Virus-like Particles

Viruses
Virus-like particles are a well-established platform for vaccines, although the molecular mechanisms that underlie the extraordinary potency of many virus-like particles in eliciting strong antibody responses remain incompletely understood. Here, we show
Alexander R. Meyer, Libo Li, Wei-Yun Wholey, Bryce Chackerian, Wei Cheng   +4 more
doaj   +1 more source

Combining high-resolution cryo-electron microscopy and mutagenesis to develop cowpea mosaic virus for bionanotechnology

, 2017
Particles of cowpea mosaic virus (CPMV) have enjoyed considerable success as nanoparticles. The development of a system for producing empty virus-like particles (eVLPs) of the virus, which are non-infectious and have the potential to be loaded with ...
Alex Durrant, Aljabali, Dalsgaard, Emma L. Hesketh, George P. Lomonossoff, Goddard, Hesketh, Hesketh,, Huynh, Jaafar,, Johnson, Kimanius, Lin, Lin, Lomonossoff, Lomonossoff, Montague, Neil A. Ranson, Porta, Porta, Rae, Sainsbury, Sainsbury, Sainsbury, Saunders, Singh, Steele, Steinmetz, Taylor, Taylor, Usha, Wen, Yulia Meshcheriakova   +32 more
core   +1 more source