Results 241 to 250 of about 214,356 (305)

In vitro characterization of cellular responses elicited by endosomal TLR agonists encapsulated in Qβ virus-like particles. [PDF]

BMC Immunol
Hasibuzzaman MM, Ibarra B, Khan IN, Meagher TC, Lemke-Miltner CD, Weiner GJ, Simons AL.   +6 more
europepmc   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Customised virus-like particles: Opening a new chapter for clinical precision gene therapy. [PDF]

Clin Transl Med
Zhu X, Zhang Q, Zhou X, Cai Y, Hong J.
europepmc   +1 more source

Synergistic Remodeling of Tumor Immune Microenvironment via a DNA Nanodevice Integrating STING Activation and Lysosome‐Targeted PD‐L1 Degradation

Advanced Science, EarlyView.
A rational design DNA nanoplatform not only achieves efficient PD‐L1 degradation but also triggers robust STING signaling. The nanodevice effectively reprograms “cold” tumors, leading to potent inhibition of tumor growth and metastasis in vivo. ABSTRACT The cGAS‐STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic ...
Haoxiang Li, Min Hou, Shasha Sun, Jun Cao, Jian‐Hui Jiang, Jianjun He   +5 more
wiley   +1 more source

Modular Virus-like Particles for Antigen Presentation: Comparing Genetic Fusion and Click-Chemistry for Purification. [PDF]

Int J Mol Sci
Balbierer K, Jenzelewski V, Herrmann FC, Piontek M, Jose J.   +4 more
europepmc   +1 more source

Muscle-specific gene editing therapy via mammalian fusogen-directed virus-like particles. [PDF]

Nat Commun
Zhou SK, Luo JT, Chen YF, Lu ZD, Jian QH, Jiang SQ, Li J, Zhang XQ, Tan XY, Yang XZ, Xu CF, Wang J.   +11 more
europepmc   +1 more source

Stabilization of norovirus GII.3 virus-like particles by rational disulfide engineering. [PDF]

NPJ Vaccines
Warren C, Galli JD, Bystol K, O'Donnell G, Swartz AR, Dewar EA, Fulton CM, Shen P, Gonzalez-Fernandez E, DeWitt LA, Jeong U, Pan OC, Miller S, Fridman A, David C, Chen Z, Wei J.   +16 more
europepmc   +1 more source

Protection Against Toxoplasma gondii Lethal ME49 Challenge Induced by Influenza Virus-like Particles Containing Dense Granule Protein 14. [PDF]

Pharmaceutics
Mao J, Kang HJ, Eom GD, Heo SI, Nam H, Lee JH, Park KH, Lee MS, Kim SS, Quan FS.   +9 more
europepmc   +1 more source

Virus-like Particles Formed by the Coat Protein of the Single-Stranded RNA Phage PQ465 as a Carrier for Antigen Presentation. [PDF]

Molecules
Vasyagin EA, Mardanova ES, Ravin NV.
europepmc   +1 more source