Results 81 to 90 of about 778,919 (247)

Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins

Nature Communications, 2019
Intestinal and free-living protozoa, such as Giardia lamblia, express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects the parasite inside the host’s intestine.
M. C. Serradell, Lucía L. Rupil, R. Martino, C. Prucca, P. G. Carranza, Alicia Saura, Elmer A Fernández, P. Gargantini, Albano H. Tenaglia, J. P. Petiti, R. R. Tonelli, Nicolás M. Reinoso-Vizcaíno, J. Echenique, L. Berod, E. Piaggio, B. Bellier, T. Sparwasser, D. Klatzmann, H. Luján   +18 more
semanticscholar   +1 more source

Production in yeast of pseudotype virus-like particles harboring functionally active antibody fragments neutralizing the cytolytic activity of vaginolysin

Microbial Cell Factories, 2011
Background Recombinant antibodies can be produced in different formats and different expression systems. Single chain variable fragments (scFvs) represent an attractive alternative to full-length antibodies and they can be easily produced in bacteria or ...
Pleckaityte Milda, Zvirbliene Aurelija, Sezaite Indre, Gedvilaite Alma   +3 more
doaj   +1 more source

Virus-Like Particles as an Instrument of Vaccine Production

Molecular Biology, 2019
The paper discusses the techniques which are currently implemented for vaccine production based on virus-like particles (VLPs). The factors which determine the characteristics of VLP monomers assembly are provided in detail.
B. Syomin, Y. Ilyin
semanticscholar   +1 more source

Immunogenicity and safety of virus-like particle of the porcine encephalomyocarditis virus in pig

Virology Journal, 2011
Background In this study, porcine encephalomyocarditis virus (EMCV) virus-like particles (VLPs) were generated using a baculovirus expression system and were tested for immunogenicity and protective efficacy in vivo.
Shin Bo-Hye, Choi Hwan-Won, Jeong WooSeog, Lee Won-Ha, Jeoung Hye-Young, Lee Hee, An Dong-Jun   +6 more
doaj   +1 more source

Mosquito Cell-Derived Japanese Encephalitis Virus-Like Particles Induce Specific Humoral and Cellular Immune Responses in Mice

Viruses, 2020
The Japanese encephalitis virus (JEV) is the major cause of an acute encephalitis syndrome in many Asian countries, despite the fact that an effective vaccine has been developed.
Yu-Hsiu Chang, Der-Jiang Chiao, Yu-Lin Hsu, Chang-Chi Lin, Hsueh-Ling Wu, Pei-Yun Shu, Shu-Fen Chang, Jui-Huan Chang, Szu-Cheng Kuo   +8 more
doaj   +1 more source

Vesivirus 2117 capsids more closely resemble sapovirus and lagovirus particles than other known vesivirus structures [PDF]

, 2017
Vesivirus 2117 is an adventitious agent that in 2009, was identified as a contaminant of CHO cells propagated in bioreactors at a pharmaceutical manufacturing plant belonging to Genzyme.
Bhella, David, Carneiro, Daniel G., Conley, Michaela, Emmott, Edward, Goodfellow, Ian G., Hansman, Grant S., Murata, Kazuyoshi, Orton, Richard, Taylor, David   +8 more
core   +1 more source

Virus‐like particles: Next‐generation nanoparticles for targeted therapeutic delivery

Bioengineering & Translational Medicine, 2017
Most drug therapies distribute the agents throughout the entire body, even though the drugs are typically only needed at specific tissues. This often limits dosage and causes discomfort and harmful side‐effects.
M. Rohovie, Maya Nagasawa, J. Swartz
semanticscholar   +1 more source

Author Correction: Minimal system for assembly of SARS-CoV-2 virus like particles

Scientific Reports, 2021
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Heather Swann, Abhimanyu Sharma, Benjamin Preece, Abby Peterson, Crystal Eldredge, David M. Belnap, Michael Vershinin, Saveez Saffarian   +7 more
doaj   +1 more source

Post-authorisation experience and reported adverse events following use of a virus-like particle chikungunya vaccine, United States and Germany, up to August 2025

Eurosurveillance
Older adults are at increased risk of severe chikungunya. Some countries advise against vaccinating ≥ 60 or ≥ 65-year-olds with the licenced live-attenuated vaccine (CHIKV LA, IXCHIQ), following severe adverse event (SAE) reports.
Florian Lienert
doaj   +1 more source

Programmable polymorphism of a virus-like particle

Communications Materials, 2022
Virus-like particles are promising for drug delivery systems and vaccine development, but controlling their size and morphology is challenging. Here, amino acid sequences are inserted into MS2 bacteriophage virus-like particles, with their size and shape
Artur P. Biela, Antonina Naskalska, Farzad Fatehi, Reidun Twarock, Jonathan G. Heddle   +4 more
doaj   +1 more source