Results 171 to 180 of about 2,319 (231)

Use of Recombinant Chikungunya Virus expressing Nanoluciferase to Identify Chondrocytes as Target Cells in an Immunocompetent Mouse Model. [PDF]

J Infect Dis
Legros V, Belarbi E, Jeannin P, Geolier V, Kümmerer BM, Hardy D, Desprès P, Gessain A, Roques P, Ceccaldi PE, Choumet V.   +10 more
europepmc   +1 more source

Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders

Advanced Science, EarlyView.
Antibody can be engineered into diverse lysosome‐targeting chimeras that convert target recognition into active degradation. By coupling antibody binding with recruited receptors, encoded domains, conjugated ligands, or nanoparticle scaffolds, these antibody‐associated targeted chimeras (AbTACs) platforms direct extracellular and membrane proteins ...
Kaige Chen, Quanyin Hu
wiley   +1 more source

Anti-Herpes Simplex Virus Type 1 Activity of <i>Rosa damascena</i> Mill Essential Oil and Floral Water in Retinal Infection In Vitro and In Silico. [PDF]

Int J Mol Sci
Vilhelmova-Ilieva N, Nenova R, Kalinov K, Dobreva A, Peshev D, Iliev I.   +5 more
europepmc   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Prophylactic monoclonal antibodies against respiratory syncytial virus in early life: An in-depth review of mechanisms of action, failure factors, and future perspectives. [PDF]

Pediatr Allergy Immunol
Bizot E, Portet Sulla V, Vauloup-Fellous C, Rameix-Welti MA, Gajdos V, Seddiki N.   +5 more
europepmc   +1 more source

Polymer Concepts in Cellular Function

Advanced Science, EarlyView.
Miao Yu, Shikha Dhiman, Dorothee Dormann, Frauke Gräter, Katja Luck, Friederike Schmid, Andreas Walther, Edward A. Lemke   +7 more
wiley   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates. [PDF]

Nat Commun
Detrille A, Huvelle S, van Gils MJ, Geara T, Pascal Q, Snitselaar J, Bossevot L, Cavarelli M, Dereuddre-Bosquet N, Relouzat F, Contreras V, Chapon C, Caillé F, Sanders RW, Le Grand R, Naninck T.   +15 more
europepmc   +1 more source

Expert Consensus on Influenza Vaccine and Pneumococcal Vaccination in Elderly People With Chronic Respiratory Diseases (2024)

AGING MEDICINE, EarlyView.
This consensus describes the protective effect and safety of influenza and pneumococcal vaccines, and vaccination recommendations, aiming to promote the vaccination rate, better play the role of vaccines in preventing influenza and pneumococcal diseases, and reduce the occurrence of respiratory infections and related serious complications in elderly ...
Lijing Wang, Qiao Yu, Qiong Chen, Pulin Yu, Expert Committee of Consensus Opinion on Influenza Vaccine and Pneumococcal Vaccine Vaccination for Elderly People with Chronic Respiratory Diseases, Respiratory Group of Chinese Geriatrics Society, Yunhua Bai, Yufeng Du, Luzhao Feng, Lidong Gao, Lingyun Gao, Baimei He, Junguang Jiang, Wenjing Jiang, Yayun Nan, Zhibin Peng, Yun Peng, Zhujun Shao, Jin Tan, Yingxuan Tian, Bingxiang Wang, Yuhong Wang, Wei Wu, Jianqin Wu, Xiuping Wu, Meizhe Xin, Wei Xiong, Guogang Zhang, Qiang Zhang, Xiangyu Zhang, Zhimian Zhang, Xiongwen Zhou   +31 more
wiley   +1 more source

Genome-Wide Analyses of CCHC Family Genes and Their Expression Profiles under Drought Stress in Rose (Rosa chinensis). [PDF]

Int J Mol Sci
Li S, Xu J, Cao Y, Wu J, Liu Q, Zhang D.
europepmc   +1 more source