Results 31 to 40 of about 2,319 (231)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Immunogenicity and protective efficacy on non-adjuvanted CD40-targeting SARS-CoV-2 vaccines in non-human primatesResearch in context

EBioMedicine
Summary: Background: The emergence of antigenically distinct SARS-CoV-2 variants increases the risk of immune escape and requires continually updated vaccines.
Romain Marlin, Mireille Centlivre, Laetitia Bossevot, Anne-Sophie Gallouët, Marie Alexandre, Delphine Planas, Mariangela Cavarelli, Isabelle Staropoli, Wesley Gros, Mathieu Surenaud, Craig Fenwick, Sylvain Cardinaud, Mathilde Galhaut, Sandra Zurawski, Victor Magneron, Loïc Pintore, Cécile Hérate, Marie-Anne Rameix Welti, Paul Mazet, Vanessa Contreras, Francis Relouzat, Nathalie Dereuddre-Bosquet, Giuseppe Pantaleo, Rodolphe Thiébaut, Mélanie Prague, Olivier Schwartz, Gerard Zurawski, Véronique Godot, Roger Le Grand, Yves Lévy   +29 more
doaj   +1 more source

Transcriptome profiling of petal abscission zone and functional analysis of an Aux/IAA family gene RhIAA16 involved in petal shedding in rose

Frontiers in Plant Science, 2016
Roses are one of the most important cut flowers among ornamental plants. Rose flower longevity is largely dependent on the timing of petal shedding occurrence.
Yuerong Gao, Chun Liu, Xiaodong Li, Haiqian Xu, Yue Liang, Nan Ma, Zhangjun Fei, Junping Gao, Cai-Zhong Jiang, Cai-Zhong Jiang, Chao Ma   +10 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Root parasitic nematodes in nursery plants imported to Finland in 1980

Agricultural and Food Science, 1985
Injurious nematodes were found in 201 of the investigated 670 plant stocks of 42 imported consignments. Infections by quarantine nematodes appeared in 100 stocks of 26 consignments, 15 there of including 3 or more infected plant stocks each.
Sirpa Kurppa
doaj  

Mediator Subunit RhMED15a Regulates Drought Tolerance in Rose

Horticulturae
Mediator is a multiprotein complex integral to the transcription machinery, mediated by RNA polymerase II. Some Mediator subunits have been found to have critical functions in plants’ responses to abiotic stresses.
Xiaoman Shang, Nanxin Xie, Yalin Li, Zixin Zhao, Ping Luo, Yongyi Cui, Xianlong Rao, Wen Chen   +7 more
doaj   +1 more source