Results 71 to 80 of about 3,841 (208)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

RNA splicing patterns contribute to burst size variation among HIV-1-infected Jurkat cell clones

Journal of Virology
Accurately quantifying virus release from HIV-1-infected cells is central to predicting infection outcomes and evaluating treatment strategies. Recent studies suggest that viral shedding can vary strikingly among infected cells. To identify predictors of
Kamya Gopal, Cleo Burnett, Siarhei Kharytonchyk, Ann Emery, Edmond Atindaana, Ronald Swanstrom, Jeffrey M. Kidd, Alice Telesnitsky   +7 more
doaj   +1 more source

Viral and cellular requirements for the budding of Feline Endogenous Retrovirus RD-114

Virology Journal, 2011
Background RD-114 virus is a feline endogenous retrovirus and produced as infectious viruses in some feline cell lines. Recently, we reported the contamination of an infectious RD-114 virus in a proportion of live attenuated vaccines for dogs and cats ...
Fukuma Aiko, Abe Masumi, Urata Shuzo, Yoshikawa Rokusuke, Morikawa Yuko, Miyazawa Takayuki, Yasuda Jiro   +6 more
doaj   +1 more source

Adaptation of Measles Virus to Polarized Epithelial Cells: Alterations in Virus Entry and Release

Virology, 1997
We have previously shown that the Edmonston strain of measles virus enters and is released preferentially at the apical surfaces of polarized epithelial cells. Small amounts of virus were found to be released at the basal surface. In the present study, we passaged the virus in polarized cells and characterized the passaged virus for its pattern of ...
Blau, Dianna M., Compans, Richard W.
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Tacrolimus intrapatient variability and latent virus reactivation after kidney transplantation: A retrospective study comparing prolonged-release and immediate-release tacrolimus formulations

Journal of International Medical Research
Objective This study explored the differences in intrapatient variability of tacrolimus between prolonged-release and immediate-release formulations and evaluated the association between tacrolimus intrapatient variability and reactivation of BK virus ...
Sibel Ersan, Gulin Kavakalan, Gursel Ersan, Gozde Buhur Sari, Sibel Akkurt, Mehmet Tanrisev   +5 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Insights into IAV Replication and Lipid Metabolism in Suspension-Adapted MDCK-STAT1-KO Cells

Vaccines
Objectives: The industrial production of influenza vaccines is facing significant challenges, particularly in improving virus production efficiency. Despite advances in cell culture technologies, our understanding of the production characteristics of ...
Qian Ye, Hong Yao, Zhiying Xiao, Liang Zhao, Wen-Song Tan   +4 more
doaj   +1 more source

Qualitative release assessment to estimate the likelihood of henipavirus entering the United Kingdom.

PLoS ONE, 2012
The genus Henipavirus includes Hendra virus (HeV) and Nipah virus (NiV), for which fruit bats (particularly those of the genus Pteropus) are considered to be the wildlife reservoir. The recognition of henipaviruses occurring across a wider geographic and
Emma L Snary, Vick Ramnial, Andrew C Breed, Ben Stephenson, Hume E Field, Anthony R Fooks   +5 more
doaj   +1 more source

Angiomotin functions in HIV-1 assembly and budding

eLife, 2015
Many retroviral Gag proteins contain PPXY late assembly domain motifs that recruit proteins of the NEDD4 E3 ubiquitin ligase family to facilitate virus release.
Gaelle Mercenne, Steven L Alam, Jun Arii, Matthew S Lalonde, Wesley I Sundquist   +4 more
doaj   +1 more source