Results 141 to 150 of about 509,253 (315)

Class A scavenger receptor 1 (MSR1) restricts hepatitis C virus replication by mediating toll-like receptor 3 recognition of viral RNAs produced in neighboring cells

, 2013
Persistent infections with hepatitis C virus (HCV) may result in life-threatening liver disease, including cirrhosis and cancer, and impose an important burden on human health.
McGivern, David R., Fengyu Hu, Daisuke Yamane (206804), David R McGivern, Hu, Fengyu, Hiromichi Dansako (357935), Nobuyuki Kato (235685), Christoph Welsch (22852), Stanley M. Lemon (30543), Daisuke Yamane, Christoph Welsch, Welsch, Christoph, David R. McGivern (415119), Lemon, Stanley M., Kato, Nobuyuki, Fengyu Hu (415120), Dansako, Hiromichi, Stanley M Lemon, Yamane, Daisuke, Nobuyuki Kato, Hiromichi Dansako   +20 more
core   +1 more source

A Proof‐of‐Concept Assessment of a Novel Wearable Eyelid Muscle Device: A Pre‐Clinical Animal Cadaver Study for Eyelid Closure Restoration

Advanced Robotics Research, EarlyView.
This article introduces a soft wearable eyelid sling device incorporating a hydraulic soft artificial muscle (SAM) for achieving complete closure of an eyelid. The SAM is driven by a cam mechanism that provides a displacement profile closely matched with those of a healthy eyelid.
Patrick Pruscino, Phuoc Thien Phan, James Davies, Bibhu Sharma, Tianruo Guo, Chi Cong Nguyen, Nigel H. Lovell, Thanh Nho Do   +7 more
wiley   +1 more source

Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein

, 2016
Chikungunya virus (CHIKV; genus Alphavirus, family Togaviridae) has recently caused several major outbreaks affecting millions of people. There are no licensed vaccines or antivirals, and the knowledge of the molecular biology of CHIKV, crucial for ...
Ahola, Tero, Utt, Age, Saul, Sirle, Merits, Andres, Age Utt, Quirin, Tania, Hellstrom, Kirsi, Tero Ahola, Andres Merits, Sirle Saul, Kirsi Hellström, Tania Quirin   +11 more
core   +1 more source

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source

On the Replication of Vaccinia Virus

Cold Spring Harbor Symposia on Quantitative Biology, 1962
N P, SALZMAN, A J, SHATKIN, E D, SEBRING, W, MUNYON   +3 more
openaire   +2 more sources

RNAi Screening in Tumor Cells Identifies Artificial microRNAs That Improve Oncolytic Virus Replication

Pharmaceuticals
Background/Objectives: Oncolytic viruses infect and kill tumor cells while leaving normal cells unharmed. They are often attenuated through the reduction in their ability to antagonize antiviral defenses, leading to robust replication in tumor cells ...
Hannah Klemets, Angelina Bardoul, Adrian Pelin, Ragunath Singaravelu, Meaghan Boileau, Theresa Falls, Julia Petryk, Marie-Claude Bourgeois-Daigneault, John C. Bell, Dominic G. Roy   +9 more
doaj   +1 more source

Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation

Advanced Science, EarlyView.
Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater, Savvas Kourtis, Camilla Reiter Elbæk, Lorena Espinar, Carolina Toro‐Márquez, Albert Coll‐Manzano, Alfredo Smiriglia, Laura García‐López, Laura Wiegand, Maria Guirola, Frédéric Fontaine, Andrea Morandi, André C. Müller, Sara Sdelci   +13 more
wiley   +1 more source

Lipid Droplets in Virus Replication

FEBS Letters
Intracellular pathogens rely on host metabolic networks for multiplication. Enveloped viruses need lipids for formation of the viral envelope and positive sense RNA viruses that replicate in membranous inclusions require lipids for formation of the replication compartments.
openaire   +3 more sources

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

HLA-Associated viral mutations are common in human immunodeficiency virus type 1 elite controllers

, 2009
Elite controllers (EC) of human immunodeficiency virus type 1 (HTV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8+ T lymphocytes are believed to play a crucial role in viral containment ...
C. J. Brumme, F. Pereyra, Harrigan, P. R., Brumme, Z. L., John, M., B. D. Walker, Brockman, M. A., P. R. Harrigan, T. Miura, Miura, T., Block, B. L., Trocha, A., M. A. Brockman, M. John, A. Trocha, Z. L. Brumme, S. Mallal, Pereyra, F., Walker, B. D., B. L. Block, Brumme, C. J., Mallal, S.   +21 more
core   +1 more source