Results 191 to 200 of about 3,896,668 (306)

Comprehensive genomic characterization of the soybean G3PDH gene family and its role in virus resistance. [PDF]

BMC Plant Biol
Huang K, Sekine KT, Li S, Xu H, Song D, Kachroo P, Kachroo A, Luan H.   +7 more
europepmc   +1 more source

Next-generation sequencing analysis of hepatitis C virus resistance-associated substitutions in direct-acting antiviral failure in South Korea. [PDF]

Clin Mol Hepatol, 2023
Kim KA, Lee S, Park HJ, Jang ES, Lee YJ, Cho SB, Kim YS, Kim IH, Lee BS, Chung WJ, Ahn SH, Kim S, Jeong SH.   +12 more
europepmc   +1 more source

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source

Genetic Code-Locking Confers Stable Virus Resistance to a Recoded Organism. [PDF]

Biochemistry
Zürcher JF, Dickson A, Kappes T, Kleefeldt AA, Liu KC, Salmond GPC, Chin JW.   +6 more
europepmc   +1 more source

Mutagenesis of the melon Prv gene by CRISPR/Cas9 breaks papaya ringspot virus resistance and generates an autoimmune allele with constitutive defense responses. [PDF]

J Exp Bot, 2023
Nizan S, Amitzur A, Dahan-Meir T, Benichou JIC, Bar-Ziv A, Perl-Treves R.   +5 more
europepmc   +1 more source

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics‐Based Optimization with Limited Activity Data

Advanced Science, EarlyView.
Using a minimal set of experimentally labeled antimicrobial and non‐antimicrobial peptides, we reconstruct the effective lipid composition of a pathogenic membrane ‐demonstrated at the example of bacterial membranes‐ through a physics‐based evolutionary molecular dynamics (Evo‐MD) approach. Optimization based on peptide insertion reveals broad‐spectrum
Maximilian Krebs, Herre Jelger Risselada
wiley   +1 more source

Identification of a QTL region for tomato brown rugose fruit virus resistance in Solanum pimpinellifolium. [PDF]

Theor Appl Genet
Jaiswal N, Zia B, Chanda B, Gilliard A, Shi A, Ling KS.   +5 more
europepmc   +1 more source

Mapping and functional characterization of the tomato spotted wilt virus resistance gene SlCHS3 in Solanum lycopersicum. [PDF]

Mol Breed, 2022
Lv J, Deng M, Jiang S, Zhu H, Li Z, Wang Z, Li J, Yang Z, Yue Y, Xu J, Zhao K.   +10 more
europepmc   +1 more source

Hepatitis C Virus Resistance-Associated Substitutions in Mexico. [PDF]

Viruses
Jose-Abrego A, Laguna-Meraz S, Roman S, Mariscal-Martinez IM, Panduro A.   +4 more
europepmc   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source