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Antiviral defense systems in the rumen microbiome [PDF]

mSystems
The continuous interaction between phages and their respective hosts has resulted in the evolution of multiple bacterial immune mechanisms. However, the diversity and prevalence of antiviral defense systems in complex communities are still unknown.
Johan S. Sáenz, Bibiana Rios-Galicia, Jana Seifert   +2 more
doaj   +4 more sources

Honey Bee and Bumble Bee Antiviral Defense [PDF]

Viruses, 2018
Bees are important plant pollinators in both natural and agricultural ecosystems. Managed and wild bees have experienced high average annual colony losses, population declines, and local extinctions in many geographic regions. Multiple factors, including
Michelle Flenniken, Marie C Pizzorno, Katie F Daughenbaugh   +2 more
exaly   +4 more sources

Argonaute 5-Mediated Antiviral Defense and Viral Counter-Defense in Nicotiana benthamiana

Virus Research, 2023
The argonaute (AGO) family proteins play a crucial role in preventing viral invasions through the plant antiviral RNA silencing pathway, with distinct AGO proteins recruited for specific antiviral mechanisms.
Yau Heiu Hsu, Chung Chi Hu, Na-Sheng Lin
exaly   +4 more sources

A Requirement for Argonaute 4 in Mammalian Antiviral Defense

Cell Reports, 2020
Summary: While interferon (IFN) responses are critical for mammalian antiviral defense, induction of antiviral RNA interference (RNAi) is evident. To date, individual functions of the mammalian RNAi and micro RNA (miRNA) effector proteins Argonautes 1–4 (
Fatemeh Adiliaghdam, Megha Basavappa, Tahnee L. Saunders, Dewi Harjanto, John T. Prior, D. Alexander Cronkite, Nina Papavasiliou, Kate L. Jeffrey   +7 more
doaj   +2 more sources

Endogenous Cellular MicroRNAs Mediate Antiviral Defense Against Influenza A Virus

Molecular Therapy - Nucleic Acids, 2018
The reciprocal interaction between influenza virus and host microRNAs (miRNAs) has been implicated in the regulation of viral replication and host tropism.
Xin Ye, Songdong Meng, Wenjun Liu
exaly   +3 more sources

A new microtubule-stabilizing agent shows potent antiviral effects against African swine fever virus with no cytotoxicity

Emerging Microbes and Infections, 2021
African swine fever virus (ASFV) is the causal agent of a fatal disease of domestic swine for which no effective antiviral drugs are available. Recently, it has been shown that microtubule-targeting agents hamper the infection cycle of different viruses.
Samvel Sirakanyan, Erik Arabyan, Astghik Hakobyan, Tamara Hakobyan, Garri Chilingaryan, Harutyun Sahakyan, Arsen Sargsyan, Grigor Arakelov, Karen Nazaryan, Roza Izmailyan, Liana Abroyan, Zaven Karalyan, Elina Arakelova, Elmira Hakobyan, Anush Hovakimyan, Andre Serobian, Marco Neves, João Ferreira, Fernando Ferreira, Hovakim Zakaryan   +19 more
doaj   +1 more source

Inhibition of African swine fever virus in liquid and feed by medium-chain fatty acids and glycerol monolaurate

Journal of Animal Science and Biotechnology, 2020
Background The ongoing African swine fever virus (ASFv) epidemic has had a major impact on pig production globally and biosecurity efforts to curb ASFv infectivity and transmission are a high priority.
Joshua A. Jackman, Astghik Hakobyan, Hovakim Zakaryan, Charles C. Elrod   +3 more
doaj   +1 more source

Dendritic Cells and Antiviral Defense

Viruses, 2020
Dendritic cells (DCs) play a fundamental and central role in the immune response, acting as a critical link between the innate and adaptive branches of immunity [...]
Robbie B. Mailliard
doaj   +1 more source

Antiviral Defense in Invertebrates

Viruses, 2018
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Michelle L. Flenniken
doaj   +1 more source

Antiviral RNAi in Insects and Mammals: Parallels and Differences

Viruses, 2019
The RNA interference (RNAi) pathway is a potent antiviral defense mechanism in plants and invertebrates, in response to which viruses evolved suppressors of RNAi.
Susan Schuster, Pascal Miesen, Ronald P. van Rij   +2 more
doaj   +1 more source