Results 11 to 20 of about 75,063 (251)
Aging impairs the antiviral defense in Caenorhabditis elegans due to loss of DRH-1/RIG-I deSUMOylation by ULP-4/SENP7 [PDF]
EMBO ReportsInnate immune defense relies on post-translational modifications (PTMs) to protect against viral infections. SUMOylation plays complex roles in viral replication and antiviral defenses in mammals and has been implicated in age-associated diseases ...
Yun Zhang, Andrew V Samuelson
doaj +2 more sources
Endogenous Cellular MicroRNAs Mediate Antiviral Defense against Influenza A Virus
Molecular Therapy - Nucleic Acids, 2018 The reciprocal interaction between influenza virus and host microRNAs (miRNAs) has been implicated in the regulation of viral replication and host tropism.
Xin Ye, Songdong Meng, Wenjun Liu
exaly +3 more sources
RNA interference: a multifaceted innate antiviral defense [PDF]
Retrovirology, 2008 The RNA interference mechanism utilizes short RNA duplexes to either suppress or induce target gene expression. Post-transcriptional regulation mediated by microRNA is an integral component of innate antiviral defense. The magnitude and the efficiency of
Kumar Ajit
doaj +3 more sources
Immunity hubs orchestrating antiviral defense. [PDF]
Cell ResZhu L, Zhang Z.
europepmc +4 more sources
Emerging Microbes and Infections, 2021 African swine fever virus (ASFV) is the causal agent of a fatal disease of domestic swine for which no effective antiviral drugs are available. Recently, it has been shown that microtubule-targeting agents hamper the infection cycle of different viruses.
Samvel Sirakanyan +19 more
doaj +1 more source
Lipids in Innate Antiviral Defense [PDF]
Cell Host & Microbe, 2013 It is becoming apparent that infections by a major class of viruses, those with envelopes, can be inhibited during their entry at the step of fusion with cellular membranes. In this review, we discuss multiple innate immune mechanisms that have evolved to modify the lipid composition of cellular and viral membranes to inhibit virion fusion of enveloped
Schoggins, John W., Randall, Glenn
openaire +2 more sources
Antiviral defense: interferons and beyond [PDF]
The Journal of Experimental Medicine, 2006 Mice lacking the adaptor protein that initiates an antiviral response downstream of the RNA helicases retinoic acid–inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) have recently been described. These studies highlight the essential and nonredundant role of nucleic acid recognition in the induction of type I interferon ...
Stetson, Daniel B., Medzhitov, Ruslan
openaire +2 more sources
Journal of Animal Science and Biotechnology, 2020 Background The ongoing African swine fever virus (ASFv) epidemic has had a major impact on pig production globally and biosecurity efforts to curb ASFv infectivity and transmission are a high priority.
Joshua A. Jackman +3 more
doaj +1 more source
A Requirement for Argonaute 4 in Mammalian Antiviral Defense
Cell Reports, 2020 Summary: While interferon (IFN) responses are critical for mammalian antiviral defense, induction of antiviral RNA interference (RNAi) is evident. To date, individual functions of the mammalian RNAi and micro RNA (miRNA) effector proteins Argonautes 1–4 (
Fatemeh Adiliaghdam +7 more
doaj +1 more source
Microbial Arsenal of Antiviral Defenses. Part II [PDF]
Biochemistry (Moscow), 2021 Abstract Bacteriophages or phages are viruses that infect bacterial cells (for the scope of this review we will also consider viruses that infect Archaea). The constant threat of phage infection is a major force that shapes evolution of microbial genomes.
Artem B, Isaev +2 more
openaire +4 more sources