Results 21 to 30 of about 75,063 (251)
Virophages and retrotransposons colonize the genomes of a heterotrophic flagellate
eLife, 2021 Virophages can parasitize giant DNA viruses and may provide adaptive anti-giant virus defense in unicellular eukaryotes. Under laboratory conditions, the virophage mavirus integrates into the nuclear genome of the marine flagellate Cafeteria burkhardae ...
Thomas Hackl +4 more
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What Are the Functional Roles of Piwi Proteins and piRNAs in Insects?
Insects, 2023 Research on Piwi proteins and piRNAs in insects has focused on three experimental models: oogenesis and spermatogenesis in Drosophila melanogaster, the antiviral response in Aedes mosquitoes and the molecular analysis of primary and secondary piRNA ...
Dulce Santos +5 more
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Cell senescence is an antiviral defense mechanism [PDF]
Scientific Reports, 2016 AbstractCellular senescence is often considered a protection mechanism triggered by conditions that impose cellular stress. Continuous proliferation, DNA damaging agents or activated oncogenes are well-known activators of cell senescence. Apart from a characteristic stable cell cycle arrest, this response also involves a proinflammatory phenotype known
Baz-Martínez, Maite +11 more
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Antiviral RNAi in Insects and Mammals: Parallels and Differences
Viruses, 2019 The RNA interference (RNAi) pathway is a potent antiviral defense mechanism in plants and invertebrates, in response to which viruses evolved suppressors of RNAi.
Susan Schuster +2 more
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Cell Reports, 2018 Summary: Rhinovirus is a leading cause of acute respiratory infections and asthma attacks, but infections are also frequently cleared from the nasal mucosa without causing symptoms.
Valia T. Mihaylova +7 more
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Interchromosomal Huddle Kickstarts Antiviral Defense [PDF]
Cell, 2008 Long-distance chromosomal interactions are emerging as a potential mechanism of gene expression control. In this issue, Apostolou and Thanos (2008) describe how viral infection elicits interchromosomal associations between the interferon-beta (IFN-beta) gene enhancer and DNA binding sites of the transcription factor NF-kappaB, resulting in the ...
Schoenfelder, Stefan, Fraser, Peter
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The Evolution of Antiviral Defense Systems [PDF]
Cell Host & Microbe, 2016 Self-replicating genetic material presumably provided the architecture necessary for generating the last universal ancestor of all nucleic-acid-based life. As biological complexity increased in the billions of years that followed, the same genetic material also morphed into a wide spectrum of viruses and other parasitic genetic elements.
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Amphibian macrophage development and antiviral defenses [PDF]
Developmental & Comparative Immunology, 2016 Macrophage lineage cells represent the cornerstone of vertebrate physiology and immune defenses. In turn, comparative studies using non-mammalian animal models have revealed that evolutionarily distinct species have adopted diverse molecular and physiological strategies for controlling macrophage development and functions.
Leon Grayfer, Jacques Robert
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Defense Mechanisms against Viral Infection in Drosophila: RNAi and Non-RNAi
Viruses, 2018 RNAi is considered a major antiviral defense mechanism in insects, but its relative importance as compared to other antiviral pathways has not been evaluated comprehensively.
Luc Swevers, Jisheng Liu, Guy Smagghe
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Scientific Reports, 2017 Recent high annual losses of honey bee colonies are associated with many factors, including RNA virus infections. Honey bee antiviral responses include RNA interference and immune pathway activation, but their relative roles in antiviral defense are not ...
Laura M. Brutscher +2 more
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