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Influenza virus host resistance model
Methods, 2007Host resistance (HR) models are used to evaluate the effect of a test article on clearance of an infectious microorganism in order to assess total immunocompetence. HR models serve as biomarkers of net immunological health or immunological well-being.
Gary R, Burleson, Florence G, Burleson
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1988
Drug resistance in viruses is generally considered to be an acquired heritable change which is characterised by relief from inhibition by a particular drug. This is always the result of one or more mutations in the virus genome, causing changes in targets for the drug or its metabolites which are reflected in a measurable difference in sensitivity ...
Hugh J. Field, Lindsey J. Owen
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Drug resistance in viruses is generally considered to be an acquired heritable change which is characterised by relief from inhibition by a particular drug. This is always the result of one or more mutations in the virus genome, causing changes in targets for the drug or its metabolites which are reflected in a measurable difference in sensitivity ...
Hugh J. Field, Lindsey J. Owen
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Antivirals and resistance: influenza virus
Current Opinion in Virology, 2011Influenza causes annual epidemics of respiratory viral infections are associated with significant morbidity and mortality. Influenza vaccines have been shown to reduce the risk of infection and mitigate against some of the virus' sequellae. Likewise, two classes of antivirals, the adamantanes (amantadine and rimantadine) and the neuraminidase ...
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1991
About 10% of world crop production is lost annually because of plant diseases caused by bacteria, fungi and viruses (Fraser, 1985). Crop losses as a result of virus diseases can be especially serious in developing countries in tropical and subtropical regions.
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About 10% of world crop production is lost annually because of plant diseases caused by bacteria, fungi and viruses (Fraser, 1985). Crop losses as a result of virus diseases can be especially serious in developing countries in tropical and subtropical regions.
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Virus drug-resistance: mechanisms and consequences
Antiviral Research, 1984Etude du developpement de la resistance des virus a des antiviraux dont l'activite est etablie depuis longtemps. Etude du mode d'action des inhibiteurs de l'herpesvirus hominis, des mecanismes de la resistance et des proprietes pathogenes des mutants resistants.
B A, Larder, G, Darby
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Influenza Virus Resistance to Antiviral Therapy
2013Antiviral drugs for influenza therapy and prophylaxis are either of the adamantane or neuraminidase inhibitor (NAI) class. However, the NAIs are mainly prescribed nowadays, because of widespread adamantane resistance among influenza A viruses and ineffectiveness of adamantanes against influenza B.
Vries, Erhard +4 more
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Hepatitis C virus and interferon resistance
Microbes and Infection, 2000Interferon plays a critical role in the host's natural defense against viral infections and in their treatment. It is the only therapy for hepatitis C virus (HCV) infection; however, many virus isolates are resistant. Several HCV proteins have been shown to possess properties that enable the virus to evade the interferon-mediated cellular antiviral ...
D R, Taylor, S T, Shi, M M, Lai
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Influenza virus resistance to neuraminidase inhibitors
Drug Resistance Updates, 1998The recent reports from Hong Kong of an avian influenza virus which caused the death of six people has served to remind us of the constant threat of pandemics posed by influenza. Recently, structure-based drug design has resulted in the discovery of a new class of antiviral agents which specifically target the influenza virus neuraminidase.
D B, Mendel, R W, Sidwell
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Fatal Oseltamivir-Resistant Influenza Virus Infection
New England Journal of Medicine, 2008The incidence of influenza A (H1N1) viruses that carry the neuraminidase H274Y mutation has increased by 30% this year in the Netherlands. This case suggests that this oseltamivir-resistant virus can be pathogenic, at least in an immunocompromised patient.
Vries, Erhard +2 more
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Virus Susceptibility and Resistance in Lettuce
2006Lettuce (Lactuca sativa) is a widely cultivated crop. Historically, the ancient Egyptians cultivated lettuce for its seed oil, which they believed had relaxing and aphrodisiac properties. Later, the Victorian English and others used its latex as a substitute for opium (“lactucarium”).
Candresse, Thierry +3 more
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