Results 61 to 70 of about 3,896,668 (306)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Successive increases in the resistance of Drosophila to viral infection through a transposon insertion followed by a Duplication [PDF]

, 2011
To understand the molecular basis of how hosts evolve resistance to their parasites, we have investigated the genes that cause variation in the susceptibility of Drosophila melanogaster to viral infection.
Magwire, Michael M, Claire L Webster, Bayer, Florian, Michael M Magwire, Cao Chuan, Francis M. Jiggins, Webster Claire L., Florian Bayer, Francis M Jiggins, Bayer Florian, Jiggins, Francis M, Chuan Cao, Cao, Chuan, Jiggins Francis M., Claire L. Webster, Webster, Claire L, Magwire Michael M., Michael M. Magwire   +17 more
core   +1 more source

Measuring Resistance to Virus Infection [PDF]

Journal of Hygiene, 1955
Dilution series of viruses often do not fit the exponential curve which they should fit if the usual assumptions of the theory of dilution series were true. Suppose the density of the virus suspension is λ, the average number of virus particles per unit volume of the inoculum (we suppose that unit volume is the amount actually used in inoculating the ...
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Evolution of lamivudine resistance in human immunodeficiency virus type 1-infected individuals:the relative roles of drift and selection [PDF]

, 2000
Human immunodeficiency virus type 1 (HIV-1) rapidly develops resistance to lamivudine during monotherapy, typically resulting in the appearance at position 184 in reverse transcriptase (RT) of isoleucine instead of the wild-type methionine (M184I) early ...
Frost, SDW, Boucher, CAB, Leigh Brown, AJ, Nijhuis, M, Schuurman, R   +4 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Resistance Against Cassava Brown Streak Viruses From Africa in Cassava Germplasm From South America

Frontiers in Plant Science, 2019
Cassava brown streak disease (CBSD) is a severe virus disease of cassava and prevalent in the eastern regions of Africa. The disease is characterized by distinct vein chlorosis and streak symptoms on leaves and stems and necrosis of storage roots.
Samar Sheat, Bettina Fuerholzner, Beate Stein, Stephan Winter   +3 more
doaj   +1 more source

Critical View on the Importance of Host Defense Strategies on Virus Distribution of Bee Viruses: What Can We Learn from SARS-CoV-2 Variants?

Viruses, 2022
Bees, both wild and domesticated ones, are hosts to a plethora of viruses, with most of them infecting a wide range of bee species and genera. Although viral discovery and research on bee viruses date back over 50 years, the last decade is marked by a ...
Niels Piot, Guy Smagghe
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Virus resistance and gene silencing : killing the messenger

, 1999
On occasion, virus-derived transgenes in plants can be poorly expressed and yet provide excellent virus resistance, and transgene constructs designed to supplement the expression of endogenous genes can have the effect of co-suppressing themselves and ...
Waterhouse, Peter M., Wang, Ming-Bo, Smith, Neil A.   +2 more
core   +1 more source