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Virus Safety of Xenotransplantation [PDF]

Viruses, 2022
The practice of xenotransplantation using pig islet cells or organs is under development to alleviate the shortage of human donor islet cells or organs for the treatment of diabetes or organ failure.
Joachim Denner
doaj   +2 more sources

Determination of optimum nanofiltration conditions for the manufacturing process of human normal immunoglobulin G for intravenous administration

Биопрепараты: Профилактика, диагностика, лечение, 2023
Scientific relevance. Medicinal products based on immunoglobulin class G (IgG) from human plasma are widely used in clinical practice to treat bacterial and viral infections, primary and secondary immunodeficiencies, and autoimmune diseases ...
N. V. Zubkova, A. M. Nikolaeva, A. V. Ivanov, O. V. Beliakova, M. V. Razumikhin, N. V. Vinokurova, I. S. Efimova, T. I. Smolyanova, E. I. Sakanyan   +8 more
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Porcine Endogenous Retroviruses and Xenotransplantation, 2021

Viruses, 2021
Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs, and some of them are able to infect human cells. Therefore, PERVs pose a risk for xenotransplantation, the transplantation of pig cells, tissues, or organ to humans in ...
Joachim Denner
doaj   +1 more source

Inactivation of Hepatitis A Virus and Human Norovirus in Clams Subjected to Heat Treatment

Frontiers in Microbiology, 2021
Bivalve mollusk contamination by enteric viruses, especially human noroviruses (HuNoV) and hepatitis A virus (HAV), is a problem with health and economic implications.
Cristina Fuentes, Cristina Fuentes, Francisco J. Pérez-Rodríguez, Francisco J. Pérez-Rodríguez, Aurora Sabrià, Aurora Sabrià, Nerea Beguiristain, Nerea Beguiristain, Rosa M. Pintó, Rosa M. Pintó, Susana Guix, Susana Guix, Albert Bosch, Albert Bosch   +13 more
doaj   +1 more source

Cap-snatching inhibitors of influenza virus are inhibitory to the in vitro transcription of rice stripe virus

Phytopathology Research, 2022
Rice stripe virus (RSV) is one of the most important viral pathogens of rice in East Asia. The transcription of RSV is initiated by cap-snatching, a mechanism shared by influenza virus (IFV).
Wenzhong Lin, Qingchen Zha, Wenwen Zhang, Guanwei Wu, Fei Yan, Zujian Wu, Zhenguo Du   +6 more
doaj   +1 more source

A new rapid and sensitive method for detecting chicken infectious anemia virus

Frontiers in Microbiology, 2022
Since the chicken infectious anemia virus (CIAV) was discovered in 1979, which has been reported as an economically significant and immunosuppressive poultry disease in the world.
Xiuhong Wu, Xiuhong Wu, Xiuhong Wu, Jie Kong, Jie Kong, Jie Kong, Ziqi Yao, Ziqi Yao, Ziqi Yao, Hejing Sun, Hejing Sun, Hejing Sun, Yuanjia Liu, Zhiqiang Wu, Jiajia Liu, Hao Zhang, Hao Zhang, Haohua Huang, Haohua Huang, Jin Wang, Jin Wang, Mengjun Chen, Mengjun Chen, Yichen Zeng, Yichen Zeng, Yinpeng Huang, Yinpeng Huang, Feng Chen, Feng Chen, Feng Chen, Qingmei Xie, Qingmei Xie, Qingmei Xie, Xinheng Zhang, Xinheng Zhang, Xinheng Zhang   +35 more
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Clustered Cases of Waterborne Hepatitis E Virus Infection, France

Viruses, 2023
The identification of seven cases of hepatitis E virus infection in a French rural hamlet in April 2015 led to investigations confirming the clustering and identifying the source of the infection.
Sébastien Lhomme, Sébastien Magne, Sylvie Perelle, Emmanuelle Vaissière, Florence Abravanel, Laetitia Trelon, Catherine Hennechart-Collette, Audrey Fraisse, Sandra Martin-Latil, Jacques Izopet, Julie Figoni, Guillaume Spaccaferri   +11 more
doaj   +1 more source

Multiplex Human Papillomavirus L1L2 virus-like particle antibody binding assay

MethodsX, 2022
A variety of in vitro techniques are available to estimate the level of antibodies present in human serum samples. Such tests are highly specific and are used to determine prior exposure to a pathogen or to estimate the magnitude, breadth and durability ...
Kavita Panwar, Anna Godi, Clementina E. Cocuzza, Nick Andrews, Jo Southern, Paul Turner, Elizabeth Miller, Simon Beddows   +7 more
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Specific Plasma MicroRNA Signatures Underlying the Clinical Outcomes of Hepatitis E Virus Infection

Microbiology Spectrum, 2023
The pathogenic mechanisms determining the diverse clinical outcomes of HEV infection (e.g., self-limiting versus chronic or symptomatic versus asymptomatic) are not yet understood.
Maria I. Costafreda, Silvia Sauleda, Mar Riveiro-Barciela, Angie Rico, Meritxell Llorens-Revull, Susana Guix, Rosa M. Pintó, Albert Bosch, Francisco Rodríguez-Frías, Ariadna Rando, Maria Piron, Marta Bes   +11 more
doaj   +1 more source

Distribution of Porcine Cytomegalovirus in Infected Donor Pigs and in Baboon Recipients of Pig Heart Transplantation

Viruses, 2018
The porcine cytomegalovirus (PCMV) is a herpesvirus that may pose a risk for xenotransplantation using pig cells, tissues, or organs. Here, three orthotopic pig heart transplantations into baboons were studied.
Uwe Fiebig, Jan-Michael Abicht, Tanja Mayr, Matthias Längin, Andrea Bähr, Sonja Guethoff, Almuth Falkenau, Eckhard Wolf, Bruno Reichart, Tomoyuki Shibahara, Joachim Denner   +10 more
doaj   +1 more source