Results 51 to 60 of about 749,800 (313)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The hepatocyte traffic network in the human hepatitis A virus biological cycle from an evolutionary perspective

Communications Biology
Hepatitis A virus (HAV) egresses from hepatocytes cloaked in exosomes (eHAV). However, the traffic network used for its release from polarized hepatocytes is not completely understood. We propose that eHAV biogenesis may follow not only an ESCRT-mediated
Albert Carcereny, Alba Arrebola, Gemma Chavarria-Miró, Montserrat de Castellarnau, Cristina Fuentes, David Garcia-Pedemonte, Adán Martínez-Velázquez, Enric Ribes, Albert Bosch, Susana Guix, Maria Isabel Costafreda, Rosa M. Pintó   +11 more
doaj   +1 more source

Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors [PDF]

, 2010
Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV.
Atkins, H, Bell, JC, Breitbach, C, Cox, J, De Silva, N, Diallo, JS, Falls, T, Guimond, T, Huang, B, Kirn, D, Le Boeuf, F, MacTavish, H, McCart, AJ, Simmons, JG, Stanford, M, Thorne, S   +15 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Screening for Viruses in Indigenous Greek Black Pigs

Microorganisms
The successful advancement of xenotransplantation has led to the development of highly sensitive detection systems for the screening of potentially zoonotic viruses in donor pigs and preventing their transmission to the recipient.
Hina Jhelum, Vasileios Papatsiros, Georgios Papakonstantinou, Ludwig Krabben, Benedikt Kaufer, Joachim Denner   +5 more
doaj   +1 more source

Risk assessment for the implementation of controlled human Schistosoma mansoni infection trials in Uganda [version 2; peer review: 2 approved]

AAS Open Research, 2019
Schistosomiasis is a parasitic infection highly prevalent in sub-Saharan Africa, and a significant cause of morbidity; it is a priority for vaccine development.
Jan Pieter Koopman, Moses Egesa, Anne Wajja, Moses Adriko, Jacent Nassuuna, Gyaviira Nkurunungi, Emmanuella Driciru, Gijsbert van Willigen, Stephen Cose, Maria Yazdanbakhsh, Pontiano Kaleebu, Narcis Kabatereine, Edridah Tukahebwa, Meta Roestenberg, Alison M. Elliott   +14 more
doaj   +1 more source

SARS-CoV-2 Pandemic and Food Safety Oversight: Implications in Canada and Coping Strategies

Foods, 2021
The SARS-CoV-2 pandemic has created enormous societal disruptions in the Western world, including Canada, with serious implications for food safety.
Sylvain Charlebois, Janet Music
doaj   +1 more source

Virus-Like Particle-Mediated Vaccination against Interleukin-13 May Harbour General Anti-Allergic Potential beyond Atopic Dermatitis [PDF]

, 2020
Virus-like particle (VLP)-based anti-infective prophylactic vaccination has been established in clinical use. Although validated in proof-of-concept clinical trials in humans, no VLP-based therapeutic vaccination against self-proteins to modulate chronic
Foerster, John, Molęda, Aleksandra
core   +2 more sources

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source