Results 61 to 70 of about 377,160 (316)

PDA/FDA Virus & TSE Safety Conference [PDF]

PDA Journal of Pharmaceutical Science and Technology, 2016
In this issue, we present a summary of the 2015 PDA Virus and TSE Safety conference held in Cascais, Portugal. Starting in the mid-1990s, this conference series has discussed the state-of-the-art regarding regulatory aspects, virus testing and detection, virus reduction by the manufacturing ...
openaire   +2 more sources

Human immunodeficiency virus type 1 clade B superinfection:Evidence for differential immune containment of distinct clade B strains [PDF]

, 2005
Sequential infection with different strains of human immunodeficiency virus type 1 (HIV-1) is a rarely identified phenomenon with important implications for immunopathogenesis and vaccine development.
Yang, Otto O, Jamieson, Beth D, Leigh Brown, AJ, Little, SJ, Smith, Davey M, Daar, Eric S, Brown, Andrew J Leigh, Yang, OO, Pitt, JA, Petropoulos, CJ, Richman, DD, Balamurugan, Arumugam, Richman, Douglas D, Petropoulos, Christos J, Little, Susan J, Balamurugan, A, Daar, ES, Jamieson, BD, Smith, DM, Pitt, Jacqueline A   +19 more
core   +1 more source

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane, Giorgia Coratti, Chiara Cutrì, Antonio Varone, Riccardo Masson, Adele D'Amico, Valeria Sansone, Sonia Messina, Federica Ricci, Chiara Ticci, Claudio Bruno, Caterina Agosto, Francesca Benedetti, Antonella Pini, Sabrina Siliquini, Massimiliano Filosto, Alberto Zambon, Ilaria Bitetti, Maria Rosaria Manna, Claudia Dosi, Riccardo Zanin, Stefano Parravicini, Roberto De Sanctis, Giulia Stanca, Michela Catteruccia, Michele Tosi, Irene Mizzoni, Emilio Albamonte, Valentina Franchino, Maria Sframeli, Ilaria Cavallina, Elena Procopio, Michele Sacchini, Simone Morando, Noemi Brolatti, Federica Trucco, Gaia Scarpini, Elena Briganti, Beatrice Berti, Concetta Palermo, Daniela Leone, Stefano C. Previtali, Eugenio Mercuri, the ITASMAC working group   +43 more
wiley   +1 more source

Immunogenic Properties of a Novel Hepatitis A Vaccine Candidate Based on a Fast-Growing Viral Strain

Vaccines
Background/Objectives: Hepatitis A virus (HAV) yearly causes over 150 million new infections and around 40,000 deaths. Current vaccines are based on strains that grow poorly in cell culture, leading to high production costs and limited availability. This
Maria Isabel Costafreda, Malén Massot-Cladera, Gemma Chavarria-Miró, Alba Arrebola, Àngels Franch-Masferrer, Maria J. Rodríguez-Lagunas, Adán Martínez-Velázquez, Albert Blanco, Albert Bosch, Susana Guix, Margarida Castell, Rosa Maria Pintó   +11 more
doaj   +1 more source

52-week efficacy and safety of telbivudine with conditional tenofovir intensification at week 24 in HBeAg-positive chronic Hepatitis B [PDF]

, 2013
Background and Aims: The Roadmap concept is a therapeutic framework in chronic hepatitis B for the intensification of nucleoside analogue monotherapy based on early virologic response.
Tawesak Tanwandee (279135), Jorge Daruich, Wattana Sukeepaisarnjaroen, Rashidkhan Pathan, Eduardo Fassio, Fernando Bessone (254729), Suzane K Ono, Daruich, Jorge, Pessôa, Mário Guimarães, Yuhong Dong, Tanwandee, Tawesak, Rashidkhan Pathan (279143), Sukeepaisarnjaroen, Wattana, Mário G Pessôa, Ono, Suzane K., Teerha Piratvisuth (279131), Piyawat Komolmit (279133), Chan, Henry L. Y., Henry L Y Chan, Dong, Yuhong, Piratvisuth, Teerha, Pessôa, Mário G., Mário G. Pessôa (279138), Stefan Zeuzem (22856), Hugo Cheinquer (279142), Stefan Zeuzem, Trylesinski, Aldo, Pathan, Rashidkhan, Bessone, Fernando, Suzane K. Ono (279140), Henry L. Y. Chan (279137), Aldo Trylesinski (279145), Fassio, Eduardo, Piyawat Komolmit, Henry L. Y. Chan, Ono, Suzane Kioko, Komolmit, Piyawat, Jorge Daruich (279141), Hugo Cheinquer, Eduardo Fassio (279139), Cheinquer, Hugo, Chan, Henry, Tawesak Tanwandee, Mário G. Pessôa, Aldo Trylesinski, Suzane K. Ono, Teerha Piratvisuth, Fernando Bessone, Wattana Sukeepaisarnjaroen (279136), Yuhong Dong (279144), Zeuzem, Stefan   +50 more
core   +1 more source

Bovine Viral Diarrhea Virus and Related Pestiviruses [PDF]

, 2020
The pestiviruses encompass some of the most economically important viral infections in the cattle, swine, and sheep industries worldwide. Discovered more than 70 years ago, bovine viral diarrhea virus (BVDV) and classical swine fever virus (CSFV) were ...

core   +1 more source

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

Unveiling the enterovirus diversity in Barcelona, Spain (2020–2024) through wastewater and clinical surveillance

Emerging Microbes and Infections
Enterovirus (EV) infections are common and often mild or asymptomatic but can occasionally cause serious illness in children. Routine clinical surveillance typically underestimates the full spectrum of circulating EVs, whereas wastewater-based ...
David Garcia-Pedemonte, Albert Carcereny, Cristina Andrés, Andrés Antón, Ian Pérez, Albert Blanco, Cristina Fuentes, Maria Isabel Costafreda, Patricia Nadal-Barón, Belen Galofré, Miquel Paraira, Jacobo Mendioroz, Rosa M. Pintó, Albert Bosch, Susana Guix   +14 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source