Results 151 to 160 of about 526,290 (218)

Surveillance on California dairy farms reveals multiple possible sources of H5N1 influenza virus transmission. [PDF]

PLoS Biol
Campbell AJ, Shephard M, Paulos AP, Pauly MD, Vu MN, Stenkamp-Strahm C, Bushfield K, Hunter-Binns B, Sablon O, Bendall EE, Fitzimmons WJ, Brizuela K, Quirk GE, Kumar N, McCluskey B, Shetty N, Marr LC, Guthmiller JJ, Santos JJS, Hensley SE, Marshall ES, Abernathy K, Lauring AS, Melody BT, Wolfe MK, Lombard J, Lakdawala SS.   +26 more
europepmc   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Quantifying the role of pre-existing tissue resident cellular immunity in limiting respiratory virus transmission. [PDF]

PLoS Pathog
Saha A, Michalets SE, Uddbäck I, Ahmed H, Kohlmeier JE, Antia R, Koelle K.   +6 more
europepmc   +1 more source

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

Combinations of long terminal repeat and tax protein substitutions influence bovine leukemia virus transmission through altered viral productivity. [PDF]

Microbiol Spectr
Murakami H, Sato R, Uchiyama J, Sogawa K, Ishida H, Nagai M.   +5 more
europepmc   +1 more source

Nicotinamide Metabolism Constrains Memory CD8+ T Cell Formation Through a Putative HS1BP3‐SIRT1‐FOXO3‐BCL6 Axis

Advanced Science, EarlyView.
ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Siyang Wang, Xiaoqian Fan, Yifan Huang, Chang Yao, Jixing Fan, Yu Ping, Xuan Zhao, Congcong Li, Chunyi Shen, Jiqi Shan, Jinyan Liu, Shengdian Wang, Zhen Zhang, Yi Zhang   +13 more
wiley   +1 more source

Disruption of influenza A virus transmission in gene-edited pigs. [PDF]

Emerg Microbes Infect
Kwon T, Morozov I, McDowell CD, Lyoo EL, Artiaga BL, Li Y, Assato P, White SN, Beaton BP, Delhon G, Gaudreault NN, Richt JA.   +11 more
europepmc   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants

Advanced Science, EarlyView.
Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer, Rong Zhu, Manuel Reithofer, Gerhard Stadlmayr, Katharina Stadlbauer, Panchika Prangkio, Christoph Rippel, Markus Hahn, Aniko Eva Kasztner, Stefanie Stohl, Petr Bednar, Daniel Ruzek, David Glück, Robert Tampé, Gordana Wozniak‐Knopp, Yoo Jin Oh, Miriam Klausberger, Peter Hinterdorfer   +17 more
wiley   +1 more source

West Nile Virus Transmission Suitability Modeling for <i>Culex pipiens</i> via Temperature and Humidity. [PDF]

Geohealth
Jones HM, Brett-Major DM, Fauver JR, Gwon Y, Bell JE.   +4 more
europepmc   +1 more source