Results 121 to 130 of about 3,351,878 (358)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Epidemiological characteristics and genomic analysis of respiratory adenovirus in Lanzhou City from 2023 to 2025

Frontiers in Cellular and Infection Microbiology
ObjectiveHuman adenoviruses (HAdVs) are common pathogens causing inflammation in the upper respiratory tract, lungs, conjunctiva, urinary tract, and gastrointestinal tract.
Biao Wang, Biao Wang, Shu Liang, Huan Wei, Miao Wang, Xiaoshu Zhang, Xiaoshu Zhang, Maoxing Dong, Hui Zhang   +8 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Hepatitis C Virus Transmission in People Who Inject Drugs: Swabs May Not Be the Main Culprit [PDF]

, 2012
Lisa Maher, Handan Wand
openalex   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Characteristics of the microplate method of enzyme-linked immunosorbent assay for the detection of plant viruses.

Journal of General Virology, 1977
M. F. Clark, A. N. Adams
semanticscholar   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

A U508C synonymous mutation in the SARS-CoV-2 deletion hotspot reduces deletion frequency and accelerates viral clearance

mBio
A deletion hotspot within the non-structural protein 1 (NSP1) gene (locus 500–532) has been observed in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes analyzed by next-generation sequencing.
Kaya Miyazaki, Akihiro Doi, Yuriko Tomita, Wataru Kamitani, Shutoku Matsuyama   +4 more
doaj   +1 more source

Differential and defective expression of Koala Retrovirus indicate complexity of host and virus evolution [PDF]

, 2017
Rachael Tarlinton, Alistair R. Legione, Nishat Sarker, J. Fabijan, J. Meers, Lee McMichael, G. C. Simmons, Helen Owen, Jennifer M. Seddon, Gregory J. Dick, James Ryder, F. Hemmatzedah, Darren J. Trott, Natasha Speight, Nadine Holmes, Matthew Loose, Richard D. Emes   +16 more
openalex   +1 more source