Results 71 to 80 of about 1,996,758 (380)

FDA-Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2

open access: yesPharmaceuticals, 2020
(1) Background: Drug repositioning is an unconventional drug discovery approach to explore new therapeutic benefits of existing drugs. Currently, it emerges as a rapid avenue to alleviate the COVID-19 pandemic disease.
Ahmed Mostafa   +19 more
doaj   +1 more source

Slowly replicating lytic viruses: pseudolysogenic persistence and within-host competition [PDF]

open access: yesPhys. Rev. Lett. 102, 178103 (2009), 2008
We study the population dynamics of lytic viruses which replicate slowly in dividing host cells within an organism or cell culture, and find a range of viral replication rates that allows viruses to persist, avoiding extinction of host cells or dilution of viruses at too rapid or too slow viral replication.
arxiv   +1 more source

A systematic review of emerging respiratory viruses at the Hajj and possible coinfection with Streptococcus pneumoniae [PDF]

open access: yes, 2018
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Tawfiq, Jaffar A.   +2 more
core   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Phylogenetic analysis and docking study of neuraminidase gene of influenza A/H1N1 viruses circulating in Iran from 2010 to 2019

open access: yesVirus Research, 2023
Influenza A viruses (H1N1) have been consistently one of the most evolving viruses that escape from vaccine-induced immunity. Although there has been a rapid rise in human influenza virus knowledge since the 2009 pandemic, the molecular information about
Sina Moeini   +4 more
doaj  

Association of IFITM3 rs12252 polymorphisms, BMI, diabetes, and hypercholesterolemia with mild flu in an Iranian population

open access: yesVirology Journal, 2017
Background IFITM3 has been suggested to be associated with infection in some ethnic groups. Diabetes and hypercholesterolemia are also important clinical conditions that can predispose individuals to infection.
Parvaneh Mehrbod   +5 more
doaj   +1 more source

Computing with viruses [PDF]

open access: yes, 2016
In recent years, different computing models have emerged within the area of Unconven-tional Computation, and more specifically within Natural Computing, getting inspiration from mechanisms present in Nature.
Chen, Xu   +4 more
core  

Antigenic and genetic evolution of contemporary swine H1 influenza viruses in the United States [PDF]

open access: yes, 2018
Several lineages of influenza A viruses (IAV) currently circulate in North American pigs. Genetic diversity is further increased by transmission of IAV between swine and humans and subsequent evolution.
Anderson, T K   +5 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

The pandemic of viruses with a long incubation phase in the small world [PDF]

open access: yesarXiv, 2020
A model of the spread of viruses in selected city and in a network of cities is considered, taking into account the delay caused by the long incubation period of the virus. The effect of delay effects is shown in comparison with pandemics without such delay. A temporary asymmetry of the spread of infection has been identified, which means that the time
arxiv  

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