Results 71 to 80 of about 3,351,878 (358)

Enhanced lysis by bispecific oncolytic measles viruses simultaneously using HER2/neu or EpCAM as target receptors

Molecular Therapy: Oncolytics, 2016
To target oncolytic measles viruses (MV) to tumors, we exploit the binding specificity of designed ankyrin repeat proteins (DARPins). These DARPin-MVs have high tumor selectivity while maintaining excellent oncolytic potency.
Jan RH Hanauer, Lisa Gottschlich, Dennis Riehl, Tillmann Rusch, Vivian Koch, Katrin Friedrich, Stefan Hutzler, Steffen Prüfer, Thorsten Friedel, Kay-Martin Hanschmann, Robert C Münch, Christian Jost, Andreas Plückthun, Klaus Cichutek, Christian J Buchholz, Michael D Mühlebach   +15 more
doaj   +1 more source

Metals Explain the Relationship Between Toxoplasma gondii, Influenza Virus, and COVID-19: A Hypothesis [PDF]

, 2022
Mosab Nouraldein Mohammed Hamad
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Effects of meteorological factors and atmospheric pollutants on the prevalence of respiratory adenovirus in children in Lanzhou, Northwest China

Scientific Reports
Climate change and air pollution have significantly influenced disease prevalence and transmission. Human adenovirus (HAdV) is a common pathogen that causes acute respiratory infections in children.
Biao Wang, Hui Zhang, Maoxing Dong, Huan Wei, Miao Wang, Xiaoshu Zhang, Shu Liang   +6 more
doaj   +1 more source

Co-Infection of Swine with Porcine Circovirus Type 2 and Other Swine Viruses

Viruses, 2019
Porcine circovirus 2 (PCV2) is the etiological agent that causes porcine circovirus diseases and porcine circovirus-associated diseases (PCVD/PCVAD), which are present in every major swine-producing country in the world.
Ting Ouyang, Xinwei Zhang, Xiaohua Liu, Linzhu Ren   +3 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Transmission dynamics of avian influenza viruses in Egyptian poultry markets

npj Viruses
Live bird markets (LBMs) are considered hotspots for Avian Influenza Viruses (AIVs). In such markets, AIVs pose threats to both poultry and public health.
Sara H. Mahmoud, Mokhtar Gomaa, Ahmed El Taweel, Yassmin Moatasim, Mina Nabil Kamel, Mohamed El Sayes, Noura M. Abo Shama, Rebecca Badra, Mona Mahmoud, Pamela P. McKenzie, Richard J. Webby, Ahmed Kandeil, Mohamed Ahmed Ali, Rabeh El-Shesheny, Ghazi Kayali   +14 more
doaj   +1 more source

Occurrence of Circulating Antibodies against the Hemagglutinins of Influenza Viruses in the 2022/2023 Epidemic Season in Poland

Viruses
The aim of this study was to determine the level of anti-hemagglutinin antibodies in blood sera collected from patients during the 2022/2023 epidemic season in Poland. A total of 700 sera samples from patients across the country were tested.
Katarzyna Kondratiuk, Anna Poznańska, Karol Szymański, Emilia Czajkowska, Bartosz Mańkowski, Lidia B. Brydak   +5 more
doaj   +1 more source

Classification and Nomenclature of Viruses

Archives of Virology Supplement 10, 2014
Publisher Summary Viral taxonomists have developed a system of classification and nomenclature that embraces all viruses. From the operational point of view, viruses are divided into those that affect vertebrate animals, insects, plants, and bacteria ...
Frank Fenner, PETER A. Bachmann, E. P. J. Gibbs, FREDERICK A. Murphy, M. Studdert, D. White   +5 more
semanticscholar   +1 more source