Results 151 to 160 of about 309,484 (272)

Behavioural and neurochemical consequences of chronic gut microbiota depletion during adulthood in the rat [PDF]

, 2016
Gut microbiota colonization is a key event for host physiology that occurs early in life. Disruption of this process leads to altered brain development which ultimately manifests as changes in brain function and behaviour in adulthood. Studies using germ-
Clarke, Gerard, Cryan, John F., Dinan, Timothy G., Golubeva, Anna V., Hoban, Alan E., McVey Neufeld, Karen A., Moloney, Rachel D., O'Sullivan, Orla, Patterson, Elaine, Stanton, Catherine   +9 more
core   +1 more source

Altered peripheral CRY1 gene expression may contribute to both organic and functional gastrointestinal disease

Experimental Physiology, EarlyView.
ABSTRACT Gastrointestinal conditions such as irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD) are characterized by alterations in physiological and immune functions. Given the circadian clock influences gastrointestinal physiology and immunity, we hypothesized that the peripheral circadian clock is altered in these patients and ...
Sophie Fowler, Gemma M. Paech, Emily C. Hoedt, Jennifer C. Pryor, Cheenie Nieva, Jessica K. Bruce, Prema M. Nair, Guy D. Eslick, Simonne Sherwin, Peter Pockney, Nicholas J. Talley, Grace L. Burns, Simon Keely   +12 more
wiley   +1 more source

Intestinal metabolite homocysteine participates in the regulation of irritable bowel syndrome [PDF]

Jichu yixue yu linchuang
Objective To investigate the role of homocysteine (Hcy) in the pathogenesis of irritable bowel syndrome (IBS) and its effects on intestinal motility, visceral hypersensitivity, and barrier function.
LU Shaochong, YE Haozhen, HOU Songyuan, ZHOU Yesheng, LIU Si, ZHU Shengtao
doaj   +1 more source

Treatment of irritable bowel syndrome [PDF]

, 2005
Irritable bowel syndrome is characterised by diverse symptoms including abdominal pain, altered bowel function (increased bowel frequency, constipation), bloating, abdominal distension, the sensation of incomplete evacuation, and the increased passage of
Farthing, Michael
core   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, EarlyView.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

Estrous cycle influences excitatory amino acid transport and visceral pain sensitivity in the rat: Effects of early-life stress [PDF]

, 2016
Background: Early-life stress (ELS) is a recognized risk factor for chronic pain disorders, and females appear to be more sensitive to the negative effects of stress.
Cryan, John F., Dinan, Timothy G., Felice, Valeria D., Foley, Tara, Moloney, Rachel D., O'Mahony, Siobhain M., Sajjad, Jahangir   +6 more
core   +1 more source

Antinociceptive effect of berberine on visceral hypersensitivity in rats

World Journal of Gastroenterology, 2013
To assess the protective effect of berberine administration and the role of nitric oxide (NO) in visceral hypersensitivity.Fifty male Sprague-Dawley rats were randomly assigned to five groups. An inflammatory bowel disease model was induced in rats by intracolonic instillation of 1 mL 4% acetic acid at 8 cm proximal to the anus for 30 s and restraint ...
Tang, Qing-Lin, Lai, Min-Ling, Zhong, Yuan-Fu, Wang, Ai-Min, Su, Jun-Kai, Zhang, Ming-Qing   +5 more
openaire   +3 more sources

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Ultrasound and MRI abdominal fat distribution and its associations with metabolic conditions in adults with abdominal obesity

Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 2061-2074, March 2026.
Abstract Aims To evaluate the accuracy of abdominal fat distribution of subcutaneous (SAT) and visceral adipose tissue (VAT) assessed by ultrasound (US) compared to magnetic resonance imaging (MRI), as the gold standard technique. Additionally, to assess the association between abdominal fat distribution measured by US and metabolic conditions in ...
Claudia Jiménez‐ten Hoevel, Maria Besora‐Moreno, Judit Queral, Elisabet Llauradó, Rosa M. Valls, Rosa Solà, Anna Pedret   +6 more
wiley   +1 more source

Brain functional connectivity is associated with visceral sensitivity in women with Irritable Bowel Syndrome

NeuroImage: Clinical, 2017
Increased perception of visceral stimuli is a key feature of Irritable Bowel Syndrome (IBS). While altered resting-state functional connectivity (rsFC) has been also reported in IBS, the relationship between visceral hypersensitivity and aberrant rsFC is
Adriane Icenhour, Suzanne T. Witt, Sigrid Elsenbruch, Mats Lowén, Maria Engström, Kirsten Tillisch, Emeran A. Mayer, Susanna Walter   +7 more
doaj   +1 more source