Results 171 to 180 of about 19,706 (202)

Visceral hypersensitivity in non-erosive reflux disease

Gut, 2007
Non-erosive reflux disease (NERD) is defined as the presence of classic symptoms of gastro-oesophageal reflux disease (GORD) in the absence of oesophageal mucosal injury (or Barrett’s oesophagus) as determined by inspection at upper gastrointestinal endoscopy.1 As such it is regarded as being one of the two main phenotypes of GORD, the other being ...
C H, Knowles, Q, Aziz
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Visceral hypersensitivity and intolerance symptoms in lactose malabsorption

Neurogastroenterology & Motility, 2007
Abstract  Lactose malabsorption is not always associated with intolerance symptoms. The factors responsible for symptom onset are not yet completely known. As differences in visceral sensitivity may play a role in the pathogenesis of functional symptoms, we evaluated whether an alteration of visceral sensitivity is present in subjects with lactose ...
DI STEFANO, MICHELE, MICELI, EMANUELA, MAZZOCCHI, SAMANTA, TANA, PAOLA, CORAZZA, GINO ROBERTO, Moroni F   +5 more
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Visceral Pain and Hypersensitivity Disorders

2019
Visceral pain and hypersensitivity disorders are common but poorly understood, and their specific treatment is even more limited than for somatic disorders. Visceral hypersensitivity is mediated by small sensory fibers, the Aδ and C afferents, and results from their lowered activation thresholds, change in phenotype, or altered regional density ...
Rosario Privitera, Praveen Anand
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Study of visceral hypersensitivity in irritable bowel syndrome

Chinese Journal of Digestive Diseases, 2004
OBJECTIVE:  Visceral hypersensitivity is highly prevalent in most functional bowel disorders, such as irritable bowel syndrome (IBS), and activation of intestinal mast cells (MC) may play a role because they have been found in close proximity to gastrointestinal mucosal sensory nerve terminals containing neuropeptides and a bi‐directional pathway ...
Wen Zhu, Dong, Duo Wu, Zou, Zhao Shen, Li, Xiao Ping, Zou, Ai Yong, Zhu, Guo Ming, Xu, Ning, Yin, Yan Fang, Gong, Zhen Xing, Sun, Xiao Hua, Man   +9 more
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Irritable pouch syndrome is characterized by visceral hypersensitivity

Inflammatory Bowel Diseases, 2011
Irritable pouch syndrome (IPS) is a functional disorder in patients with ileal pouch-anal anastomosis (IPAA), which presents with symptoms in the absence of structural abnormalities of the pouch. Thus, it resembles other functional disorders, such as irritable bowel syndrome characterized by visceral hypersensitivity in the presence of normal rectal ...
Bo, Shen, Claudia, Sanmiguel, Ana E, Bennett, Lei, Lian, Brett, Larive, Feza H, Remzi, Victor W, Fazio, Edy E, Soffer   +7 more
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Mechanisms Underlying Visceral Hypersensitivity in Irritable Bowel Syndrome

Current Gastroenterology Reports, 2011
Visceral hypersensitivity is currently considered a key pathophysiological mechanism involved in pain perception in large subgroups of patients with functional gastrointestinal disorders, including irritable bowel syndrome (IBS). In IBS, visceral hypersensitivity has been described in 20%-90% of patients.
BARBARA, GIOVANNI, CREMON, CESARE, DE GIORGIO, ROBERTO, DOTHEL, GIOVANNI, ZECCHI, LISA, BELLACOSA, LARA, CARINI, GIOVANNI, STANGHELLINI, VINCENZO, CORINALDESI, ROBERTO   +8 more
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Serotonergic and non‐serotonergic targets in the pharmacotherapy of visceral hypersensitivity

Neurogastroenterology & Motility, 2007
Abstract  Visceral hypersensitivity is considered a key mechanism in the pathogenesis of functional gastrointestinal (GI) disorders. Targeting visceral hypersensitivity seems an attractive approach to the development of drugs for functional GI disorders. This review summarizes current knowledge on targets for the treatment of visceral hypersensitivity,
BUENO L., DE PONTI, FABRIZIO, FRIED M., KULLAK UBLICK G. A., KWIATEK M. A., POHL D., QUIGLEY E. M. M., TACK J., TALLEY N. J.   +8 more
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P2X receptor-mediated visceral hyperalgesia in a rat model of chronic visceral hypersensitivity

Gut, 2008
Background: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterised by abdominal pain and bloating in association with altered bowel movements. Its pathogenesis and the underlying molecular mechanisms of visceral hyperalgesia remain elusive. Recent studies of somatic and other visceral
G-Y, Xu, M, Shenoy, J H, Winston, S, Mittal, P J, Pasricha   +4 more
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Visceral hypersensitivity in functional disorders of the upper gastrointestinal tract

Digestive and Liver Disease, 2004
Visceral hypersensitivity is now recognised as a major pathophysiological mechanism in functional gastrointestinal disorders of the upper gastrointestinal tract. In patients with non-cardiac chest pain and functional dyspepsia, a high prevalence of visceral hypersensitivity has been indeed observed.
G, Sarnelli, J, Vandenberghe, J, Tack
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Review article: visceral hypersensitivity.

Alimentary pharmacology & therapeutics, 2003
Visceral hypersensitivity is highly prevalent in all functional bowel disorders. Most also demonstrate wider patterns of somatic referral of intestinal pain or discomfort. This hypersensitivity may explain the symptoms as the sensitive gut can be more easily provoked by normal or abnormal motor events in the gut.
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