Molecular Mechanisms and Pathways in Visceral Pain [PDF]
CellsChronic visceral pain, a significant contributor to morbidity in the United States, affects millions and results in substantial economic costs. Despite its impact, the mechanisms underlying disorders of gut–brain interaction (DGBIs), such as irritable ...
Qiqi Zhou, George Nicholas Verne
doaj +2 more sources
Paraventricular hypothalamic input to anterior cingulate cortex controls food preferences in chronic visceral pain mice [PDF]
Nature CommunicationsChronic visceral pain is frequently accompanied by changes in food preference. The paraventricular hypothalamus (PVH) and the anterior cingulate cortex (ACC) are well-known regions involved in pain processing and food intake.
Qi-Ya Xu +9 more
doaj +2 more sources
Microbiota regulates visceral pain in the mouse [PDF]
eLife, 2017 The perception of visceral pain is a complex process involving the spinal cord and higher order brain structures. Increasing evidence implicates the gut microbiota as a key regulator of brain and behavior, yet it remains to be determined if gut bacteria ...
Pauline Luczynski +7 more
doaj +6 more sources
Costly pain avoidance and its impact on the modulation and extinction of visceral pain-related fear [PDF]
Scientific ReportsAlong the gut-brain axis, visceral pain demonstrably evokes emotional learning and memory processes shaping behavior in clinically relevant ways. Avoidance motivated by learned fear may constitute a major obstacle to treatment success in extinction-based
Franziska Labrenz +3 more
doaj +2 more sources
Neural circuits regulating visceral pain [PDF]
Communications BiologyVisceral hypersensitivity, a common clinical manifestation of irritable bowel syndrome, may contribute to the development of chronic visceral pain, which is a major challenge for both patients and health providers.
Xiaoli Chang +2 more
doaj +2 more sources
Sex Differences in Visceral Pain and Comorbidities: Clinical Outcomes, Preclinical Models, and Cellular and Molecular Mechanisms [PDF]
CellsSexual dimorphism of visceral pain has been documented in clinics and experimental animal models. Aside from hormones, emerging evidence suggests the sex-differential intrinsic neural regulation of pain generation and maintenance.
Namrata Tiwari, Liya Y. Qiao
doaj +2 more sources
Sex-specific post-inflammatory dysbiosis mediates chronic visceral pain in colitis [PDF]
Gut MicrobesBackground Despite achieving endoscopic remission, over 20% of inflammatory bowel disease (IBD) patients experience chronic abdominal pain. Visceral pain and the microbiome exhibit sex-dependent interactions, while visceral pain in IBD shows a sex bias ...
Maria J. Arzamendi +13 more
doaj +2 more sources
Alterations in prefrontal-limbic functional activation and connectivity in chronic stress-induced visceral hyperalgesia. [PDF]
, 2013 Repeated water avoidance stress (WAS) induces sustained visceral hyperalgesia (VH) in rats measured as enhanced visceromotor response to colorectal distension (CRD).
Bota, Mihail +6 more
core +12 more sources
TGR5 agonists induce peripheral and central hypersensitivity to bladder distension
Scientific Reports, 2022 The mechanisms underlying chronic bladder conditions such as interstitial cystitis/bladder pain syndrome (IC/BPS) and overactive bladder syndrome (OAB) are incompletely understood.
Ashlee Caldwell +6 more
doaj +1 more source
Visceral pain from neuroanatomy to receptors – focus on gastrointestinal pain [PDF]
Romanian Journal of Neurology, 2016 The mechanisms and nervous structures involved in visceral pain are poorly understood, although visceral pain is one of the most debilitating clinical types of pain.
Teodora Alexa-Stratulat +2 more
doaj +1 more source