Molecular Mechanisms and Pathways in Visceral Pain [PDF]
CellsChronic visceral pain, a significant contributor to morbidity in the United States, affects millions and results in substantial economic costs. Despite its impact, the mechanisms underlying disorders of gut–brain interaction (DGBIs), such as irritable ...
Qiqi Zhou, George Nicholas Verne
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A primary auditory cortex-anterior cingulate cortex circuit underlying cross-modal visceral pain modulation [PDF]
Nature CommunicationsVisceral pain represents an unmet clinical need due to the lack of safe and generalizable therapies. Given the analgesic potential of music and the underlying crosstalk between auditory and nociceptive pathways, this study aims to delineate the neural ...
Yang Yu +7 more
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Paraventricular hypothalamic input to anterior cingulate cortex controls food preferences in chronic visceral pain mice [PDF]
Nature CommunicationsChronic visceral pain is frequently accompanied by changes in food preference. The paraventricular hypothalamus (PVH) and the anterior cingulate cortex (ACC) are well-known regions involved in pain processing and food intake.
Qi-Ya Xu +9 more
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Costly pain avoidance and its impact on the modulation and extinction of visceral pain-related fear [PDF]
Scientific ReportsAlong the gut-brain axis, visceral pain demonstrably evokes emotional learning and memory processes shaping behavior in clinically relevant ways. Avoidance motivated by learned fear may constitute a major obstacle to treatment success in extinction-based
Franziska Labrenz +3 more
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Neural circuits regulating visceral pain [PDF]
Communications BiologyVisceral hypersensitivity, a common clinical manifestation of irritable bowel syndrome, may contribute to the development of chronic visceral pain, which is a major challenge for both patients and health providers.
Xiaoli Chang +2 more
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Sex Differences in Visceral Pain and Comorbidities: Clinical Outcomes, Preclinical Models, and Cellular and Molecular Mechanisms [PDF]
CellsSexual dimorphism of visceral pain has been documented in clinics and experimental animal models. Aside from hormones, emerging evidence suggests the sex-differential intrinsic neural regulation of pain generation and maintenance.
Namrata Tiwari, Liya Y. Qiao
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TGR5 agonists induce peripheral and central hypersensitivity to bladder distension
Scientific Reports, 2022 The mechanisms underlying chronic bladder conditions such as interstitial cystitis/bladder pain syndrome (IC/BPS) and overactive bladder syndrome (OAB) are incompletely understood.
Ashlee Caldwell +6 more
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Visceral pain from neuroanatomy to receptors – focus on gastrointestinal pain [PDF]
Romanian Journal of Neurology, 2016 The mechanisms and nervous structures involved in visceral pain are poorly understood, although visceral pain is one of the most debilitating clinical types of pain.
Teodora Alexa-Stratulat +2 more
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NeuroImage, 2022 Visceral pain is regarded as more salient than somatic pain. It has greater affective and emotional components, i.e., it elicits higher levels of pain-related fear and is perceived as more unpleasant than somatic pain. In this fMRI study, we examined the
Katharina Schmidt +6 more
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Disengaging spinal afferent nerve communication with the brain in live mice
Communications Biology, 2022 A surgical method in mice can selectively remove dorsal root ganglia (DRG) at specific spinal levels without interfering with other nerves, providing insight on thoracolumbar vs. lumbosacral DRG contributions to pain signalling and behaviour.
Melinda A. Kyloh +9 more
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