Results 171 to 180 of about 186,710 (291)

Construction and Validation of a Preoperative Surgical Difficulty Prediction and Risk Stratification System for Posterior Spinal Deformity Correction Surgery Based on Machine Learning ‐ Multicenter Cohort Study

open access: yesiMetaMed, EarlyView.
A web calculator, trained on multicenter data with seven Boruta‐selected preoperative features, predicts prolonged operative time for posterior spinal deformity correction to enable individualized planning and optimized operating‐room resources. ABSTRACT Operative duration reflects surgical complexity and is valuable for perioperative planning.
Chan Xu   +27 more
wiley   +1 more source

Construction of a clickable probe‐based protein chip platform for discovering covalent mIDH1 inhibitors from natural medicinal extracts

open access: yesiMeta, EarlyView.
In this study, we develop a flexible Ccc‐Chip (protein microarray + bioorthogonal click chemistry) for high‐throughput screening of natural covalent active molecules from medicinal plant extracts, identifying flavokawain C from Piper methysticum Forst as a novel covalent mIDH1 inhibitor.
Zhao Cui   +9 more
wiley   +1 more source

Differential regulation of bladder pain and voiding function by sensory afferent populations revealed by selective optogenetic activation [PDF]

open access: yes, 2010
DeBerry, Jennifer J   +7 more
core   +1 more source

Ultrasoft eutectogel electrodes for non‐invasive face nerve monitoring

open access: yesInfoMat, EarlyView.
A eutectogel with simultaneous ultra‐low modulus, conductivity, environmental stability, and biocompatibility was prepared through random copolymerization of acrylic acid and N‐(3‐sulfopropyl)‐N‐(methacryloxyethyl)‐N,N‐dimethylammonium betaine in a deep eutectic solvent.
Bin Zhu   +17 more
wiley   +1 more source

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

open access: yesInterdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen   +12 more
wiley   +1 more source

Deliberate Practice Supervision to Enhance the Effectiveness of Behavioral Activation for Depression: A Case Study

open access: yesJournal of Clinical Psychology, Volume 81, Issue 6, Page 526-537, June 2025.
ABSTRACT Deliberate Practice (DP) is a model of behavioral skill acquisition structured by several key tasks. The past decade has shown a consistent growth in interest in this form of learning for psychotherapy skills, with promising research suggesting DP training is superior to traditional learning methods of psychotherapy. This paper presents a case
Dan Sacks
wiley   +1 more source

The involvement of spinal lncRNA RT1-CE10 in chronic functional visceral pain. [PDF]

open access: yesMol Pain
Tang Y   +10 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy